CSF-1R

Catalog No.Inhibitor Name CSF-1ROther
A10025Linifanib
***
VEGFR1/FLT1,FLT3,VEGFR2/KDR
A10679OSI-930
**
FLT1,KDR,LCK
A11959GW2580
*
A13772CEP-32496
***
c-Kit,RET,PDGFRβ
A15520Pexidartinib
**
A15540BLZ945
****
A11472Ki 20227
****
VEGFR-2, PDGFRβ, c-Kit

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Linifanib (ABT-869)

    Catalog No. A10025
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    VEGFR/PDGFR inhibitor
    Linifanib (ABT-869) is a structurally novel, potent inhibitor of RTK, VEGF and PDGF with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively. Learn More
  2. OSI-930

    Catalog No. A10679
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    c-Kit/VEGFR Inhibitor
    OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively. Learn More
  3. Pexidartinib (PLX3397)

    Catalog No. A15520
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    CSF1/Kit/FLT3 inhibitor
    Pexidartinib is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. Learn More
  4. GW2580

    Catalog No. A11959
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    CSF-1R inhibitor
    GW2580 is a small-molecule, ATP-competitive inhibitor of cFMS kinase. Learn More
  5. BLZ945

    Catalog No. A15540
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    CSF1R inhibitor
    BLZ945 is a potent and selective CSF-1R kinase inhibitor. It attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas. Learn More
  6. CEP-32496

    Catalog No. A13772
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    Raf inhibitor
    CEP-32496 is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity. Learn More
  7. Ki 20227

    Catalog No. A11472
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    M-CSFR, CSF1R inhibitor
    Ki 20227 is an inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R). Learn More
  8. JNJ-28312141

    Catalog No. A12687
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    CSF1R inhibitor
    JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events. Learn More
  9. Pazopanib (GW-786034)

    Catalog No. A11518
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    VEGFR inhibitor
    Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. Learn More
  10. AZD7507

    Catalog No. A16886
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    CSF-1R inhibitor
    AZD7507 is a potent and selective CSF-1R inhibitor (32 nM cell activity), AZD7507 is considered a promising compound as it retained the desired potency and oral pharmacokinetic properties of AZ683. Learn More

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