CSF-1R

Catalog No.Inhibitor Name CSF-1ROther
A10025Linifanib
***
VEGFR1/FLT1,FLT3,VEGFR2/KDR
A10679OSI-930
**
FLT1,KDR,LCK
A11959GW2580
*
A13772CEP-32496
***
c-Kit,RET,PDGFRβ
A15520Pexidartinib
**
A15540BLZ945
****
A11472Ki 20227
****
VEGFR-2, PDGFRβ, c-Kit

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. Linifanib (ABT-869)

    Catalog No. A10025
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    VEGFR/PDGFR inhibitor
    Linifanib (ABT-869) is a structurally novel, potent inhibitor of RTK, VEGF and PDGF with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively. Learn More
  2. Edicotinib

    Catalog No. A13008
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    CSF-1 receptor inhibitor
    Edicotinib is a selective and orally available colony-stimulating factor-1 (CSF-1) receptor inhibitor, and has entered phase IIA clinical trial to study rheumatoid arthritis (RA) despite disease. Learn More
  3. Pexidartinib (PLX3397)

    Catalog No. A15520
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    CSF1/Kit/FLT3 inhibitor
    Pexidartinib is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. Learn More
  4. BLZ945

    Catalog No. A15540
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    CSF1R inhibitor
    BLZ945 is a potent and selective CSF-1R kinase inhibitor. It attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas. Learn More
  5. CEP-32496

    Catalog No. A13772
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    Raf inhibitor
    CEP-32496 is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity. Learn More
  6. GENZ-882706

    Catalog No. A12484
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    CSF-1R Inhibitor
    GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor extracted from patent WO 2017015267A1. Learn More
  7. OSI-930

    Catalog No. A10679
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    c-Kit/VEGFR Inhibitor
    OSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively. Learn More
  8. GW2580

    Catalog No. A11959
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    CSF-1R inhibitor
    GW2580 is a small-molecule, ATP-competitive inhibitor of cFMS kinase. Learn More
  9. c-Fms-IN-8

    Catalog No. A18879
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    CSF-1R, c-FMS Type II inhibitor
    c-Fms-IN-8 (compound 4a) is a colony stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor, with an IC50 of 9.1 nM. Learn More
  10. JTE-952

    Catalog No. A18391
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    CSF-1R inhibitor
    TE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis. Learn More
  11. PLX5622

    Catalog No. A18888
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    CSF1R inhibitor
    PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM, for extended and specific microglial elimination, preceding and during pathology development. Learn More
  12. AZD7507

    Catalog No. A16886
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    CSF-1R inhibitor
    AZD7507 is a potent and selective CSF-1R inhibitor (32 nM cell activity), AZD7507 is considered a promising compound as it retained the desired potency and oral pharmacokinetic properties of AZ683. Learn More
  13. Pazopanib (GW-786034)

    Catalog No. A11518
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    VEGFR inhibitor
    Pazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. Learn More
  14. JNJ-28312141

    Catalog No. A12687
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    CSF1R inhibitor
    JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events. Learn More
  15. Ki 20227

    Catalog No. A11472
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    M-CSFR, CSF1R inhibitor
    Ki 20227 is an inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R). Learn More

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