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$0.00 CSF-1R
| Catalog No. | Inhibitor Name | CSF-1R | Other |
|---|---|---|---|
| A10025 | Linifanib | *** | VEGFR1/FLT1,FLT3,VEGFR2/KDR |
| A10679 | OSI-930 | ** | FLT1,KDR,LCK |
| A11959 | GW2580 | * | |
| A13772 | CEP-32496 | *** | c-Kit,RET,PDGFRβ |
| A15520 | Pexidartinib | ** | |
| A15540 | BLZ945 | **** | |
| A11472 | Ki 20227 | **** | VEGFR-2, PDGFRβ, c-Kit |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
15 Item(s)
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Linifanib (ABT-869)
Catalog No. A10025 VEGFR/PDGFR inhibitorLinifanib (ABT-869) is a structurally novel, potent inhibitor of RTK, VEGF and PDGF with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively. Learn More -
OSI-930
Catalog No. A10679 c-Kit/VEGFR InhibitorOSI-930 is a potent inhibitor of Kit, KDR, Flt, CSF-1R, c-Raf and Lck with IC50 of 80 nM, 9 nM, 8 nM, 15 nM, 41 nM and 22 nM, respectively. Learn More -
Pazopanib (GW-786034)
Catalog No. A11518 VEGFR inhibitorPazopanib is a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-a/β, and c-kit that blocks tumor growth and inhibits angiogenesis. Learn More -
GW2580
Catalog No. A11959 CSF-1R inhibitorGW2580 is a small-molecule, ATP-competitive inhibitor of cFMS kinase. Learn More -
Ki 20227
Catalog No. A11472 M-CSFR, CSF1R inhibitorKi 20227 is an inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R). Learn More -
CEP-32496
Catalog No. A13772 Raf inhibitorCEP-32496 is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity. Learn More -
BLZ945
Catalog No. A15540 CSF1R inhibitorBLZ945 is a potent and selective CSF-1R kinase inhibitor. It attenuates the turnover rate of TAMs while increasing the number of CD8+ T cells that infiltrate cervical and breast carcinomas. Learn More -
Pexidartinib (PLX3397)
Catalog No. A15520 CSF1/Kit/FLT3 inhibitorPexidartinib is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. Learn More -
Edicotinib
Catalog No. A13008 CSF-1 receptor inhibitorEdicotinib is a selective and orally available colony-stimulating factor-1 (CSF-1) receptor inhibitor, and has entered phase IIA clinical trial to study rheumatoid arthritis (RA) despite disease. Learn More -
GENZ-882706
Catalog No. A12484 CSF-1R InhibitorGENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor extracted from patent WO 2017015267A1. Learn More -
JNJ-28312141
Catalog No. A12687 CSF1R inhibitorJNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events. Learn More -
AZD7507
Catalog No. A16886 CSF-1R inhibitorAZD7507 is a potent and selective CSF-1R inhibitor (32 nM cell activity), AZD7507 is considered a promising compound as it retained the desired potency and oral pharmacokinetic properties of AZ683. Learn More -
PLX5622
Catalog No. A18888 CSF1R inhibitorPLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor with an Ki of 5.9 nM, for extended and specific microglial elimination, preceding and during pathology development. Learn More -
JTE-952
Catalog No. A18391 CSF-1R inhibitorTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis. Learn More -
c-Fms-IN-8
Catalog No. A18879 CSF-1R, c-FMS Type II inhibitorc-Fms-IN-8 (compound 4a) is a colony stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor, with an IC50 of 9.1 nM. Learn More
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