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Biological Activity
Sulfatinib (HMPL-012) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1/2/3, FGFR1 and CSF1R with IC50s of in a range of 1 to 24 nM.
| In vitro | DMSO | 92 mg/mL (191.43 mM) | |
| Water | <1 mg/mL | ||
| Ethanol | <1 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.81 mL | 104.04 mL | 208.08 mL |
| 0.5 mM | 4.16 mL | 20.81 mL | 41.62 mL |
| 1 mM | 2.08 mL | 10.4 mL | 20.81 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.16 mL |
*The above data is based on the productmolecular weight 480.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21915 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1308672-74-3 |
| Formula | C24H28N6O3S |
| M. Wt | 480.58 |
| Purity | >98% |
| Synonyms | HMPL-012, HMPL012, HMPL 012 |
| SMILES | O=S(CC1=CC=CC(NC2=NC=CC(OC3=CC4=C(NC(C)=C4)C=C3)=N2)=C1)(NCCN(C)C)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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