Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
- Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
Biological Activity
Linifanib (ABT-869) is a structurally novel, potent inhibitor of RTK, VEGF and PDGF with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-β, KDR, and CSF-1R, respectively.
Targets
Target | Value |
---|---|
VEGFR1/FLT1 | IC50: 3nM |
CSF-1R | IC50: 3nM |
VEGFR2/KDR | IC50: 4nM |
FLT3 | IC50: 4nM |
Kit | IC50: 14nM |
PDGFRβ | IC50: 66nM |
Tie-2 | IC50: 170nM |
VEGFR3/FLT4 | IC50: 190nM |
SGK | IC50: 940nM |
RET | IC50: 1.9μM |
PKA | IC50: 5.9μM |
Cdc2 | IC50: 9.8μM |
FGFR | IC50: >12.5μM |
Lyn | IC50: >20μM |
LCK | IC50: 38μM |
Src | IC50: >50μM |
IGFR | IC50: >50μM |
INSR | IC50: >50μM |
EGFR | IC50: >50μM |
Hck | IC50: >50μM |
c-Met | IC50: >50μM |
Fyn | IC50: >50μM |
FGR | IC50: >50μM |
Akt | IC50: >50μM |
In vitro (25°C) | DMSO | 73 mg/mL (194.45 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 5%DMSO+40%PEG 300+5%Tween80+50%ddH2O | 9 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 26.64 mL | 133.19 mL | 266.38 mL |
0.5 mM | 5.33 mL | 26.64 mL | 53.28 mL |
1 mM | 2.66 mL | 13.32 mL | 26.64 mL |
5 mM | 0.53 mL | 2.66 mL | 5.33 mL |
*The above data is based on the productmolecular weight 375.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10025 |
---|---|
Actions | Inhibitor |
CAS No. | 796967-16-3 |
Formula | C21H18FN5O |
M. Wt | 375.4 |
Purity | >98% |
Synonyms | ABT869, ABT-869 |
SMILES | CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N |
Storage | Store lyophilized at -20ºC, keep desiccated. |
1. Zhou J, Khng J, Jasinghe VJ, Bi C, Neo CH, Pan M, Poon LF, Xie Z, Yu H, Yeoh AE, Lu Y, Glaser KB, Albert DH, Davidsen SK, Chen CS: In vivo activity of ABT-869, a multi-target kinase inhibitor, against acute myeloid leukemia with wild-type FLT3 receptor. Leuk Res. 2008 Jul;32(7):1091-100. Epub 2007 Dec 26. [PubMed:18160102 ]
2. Guo J, Marcotte PA, McCall JO, Dai Y, Pease LJ, Michaelides MR, Davidsen SK, Glaser KB: Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors. Mol Cancer Ther. 2006 Apr;5(4):1007-13. [PubMed:16648572 ]
3. Albert DH, Tapang P, Magoc TJ, Pease LJ, Reuter DR, Wei RQ, Li J, Guo J, Bousquet PF, Ghoreishi-Haack NS, Wang B, Bukofzer GT, Wang YC, Stavropoulos JA, Hartandi K, Niquette AL, Soni N, Johnson EF, McCall JO, Bouska JJ, Luo Y, Donawho CK, Dai Y, Marcotte PA, Glaser KB, Michaelides MR, Davidsen SK: Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol Cancer Ther. 2006 Apr;5(4):995-1006. [PubMed:16648571 ]
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
Imatinib (Gleevec)
Imatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor.
XL647 (Tesevatinib)
XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major ro…
KRN 633
KRN 633 is a cell-permeable, reversible, ATP-competitive VEGFR kinase inhibitor that inhibits PDGFR-α and c-Kit at higher concentrations on…
R1530
R1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. R1530 is also a mitosis-angi…
Cediranib (AZD2171)
Cediranib (AZD2171) is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases.
ABT-492 (Delafloxacin)
ABT-492 is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens.
CP-673451
CP 673451 is a potent PDGFR-β inhibitor with an IC50 of 1 nM.
Masitinib mesylate
Masitinib mesylate is a novel inhibitor for Kit and PDGFRα/β with IC50 of 200 nM and 540 nM/800 nM, weak inhibition to ABL and c-Fms.
Keywords:buy Linifanib (ABT-869) | Linifanib (ABT-869) Supplier | purchase | cost | manufacturer | order | distributor | buy 796967-16-3| 796967-16-3 Supplier | purchase 796967-16-3 | 796967-16-3 cost | 796967-16-3 manufacturer | order 796967-16-3 | 796967-16-3 distributor