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- Wensheng Wang, .et al. Lymphatic endothelial cells produce M-CSF causing massive bone loss in mice, J Bone Miner Res, 2017, May; 32(5): 939-950 PMID: 28052488
Biological Activity
Ki 20227 is an inhibitor of c-Fms tyrosine kinase (M-CSFR, CSF1R).
| In vitro | DMSO | 94 mg/mL (195.61 mM) | |
| Water | <1 mg/mL | ||
| Ethanol | 3 mg/mL (6.24 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.81 mL | 104.05 mL | 208.1 mL |
| 0.5 mM | 4.16 mL | 20.81 mL | 41.62 mL |
| 1 mM | 2.08 mL | 10.4 mL | 20.81 mL |
| 5 mM | 0.42 mL | 2.08 mL | 4.16 mL |
*The above data is based on the productmolecular weight 480.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11472 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 623142-96-1 |
| Formula | C24H24N4O5S |
| M. Wt | 480.54 |
| Purity | >98% |
| Synonyms | Ki-20227, Ki20227 |
| SMILES | CC(C1=NC=CS1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)OC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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