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- Ravikanth Maddipati, .et al. MYC controls metastatic heterogeneity in pancreatic cancer, bioRxiv, 2021, February 01
- Liu M, .et al. Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal, Nat Immunol, 2019, Jan 21 PMID: 30664738
Biological Activity
GW2580 is a small-molecule, ATP-competitive inhibitor of cFMS kinase.
| In vitro (25°C) | DMSO | 48 mg/mL (131 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.29 mL | 136.46 mL | 272.92 mL |
| 0.5 mM | 5.46 mL | 27.29 mL | 54.58 mL |
| 1 mM | 2.73 mL | 13.65 mL | 27.29 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
*The above data is based on the productmolecular weight 366.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11959 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 870483-87-7 |
| Formula | C20H22N4O3 |
| M. Wt | 366.41 |
| Purity | >98% |
| Synonyms | GW 2580, GW-2580 |
| SMILES | COC1=CC=C(C=C1)COC2=C(C=C(C=C2)CC3=CN=C(N=C3N)N)OC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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Contact information
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