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Catalog No.: A11959

CSF-1R inhibitor


GW2580 Chemical Structure

CAS NO. 870483-87-7

GW2580 is a small-molecule, ATP-competitive inhibitor of cFMS kinase.

Availability: In stock

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25 mg
50 mg
100 mg
200 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Ravikanth Maddipati, .et al. MYC controls metastatic heterogeneity in pancreatic cancer, bioRxiv, 2021, February 01
  • Liu M, .et al. Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal, Nat Immunol, 2019, Jan 21 PMID: 30664738

Biological Activity

GW2580 is a small-molecule, ATP-competitive inhibitor of cFMS kinase.
In vitro (25°C) DMSO 48 mg/mL (131 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.29 mL 136.46 mL 272.92 mL
0.5 mM 5.46 mL 27.29 mL 54.58 mL
1 mM 2.73 mL 13.65 mL 27.29 mL
5 mM 0.55 mL 2.73 mL 5.46 mL

*The above data is based on the productmolecular weight 366.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11959
Actions Inhibitor
CAS No. 870483-87-7
Formula C20H22N4O3
M. Wt 366.41
Purity >98%
Synonyms GW 2580, GW-2580

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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