DFP-11207 is an orally active fluoropyrimidine cytotoxic agent designed to target and enhance the pharmacological activity of 5-fluorouracil (5-FU). It functions as a pro-drug that incorporates a reversible dihydropyrimidine dehydrogenase (DPD) inhibitor and a potent orotate phosphoribosyltransferase (OPRT) inhibitor, which together mitigate gastrointestinal and myelosuppressive toxicities associated with traditional 5-FU therapy. DFP-11207 is primarily utilized in cancer research, providing insights into more effective and safer chemotherapeutic strategies.
DFP-11207 is an orally active fluoropyrimidine cytotoxic agent designed to target and enhance the pharmacological activity of 5-fluorouracil (5-FU). It functions as a pro-drug that incorporates a reversible dihydropyrimidine dehydrogenase (DPD) inhibitor and a potent orotate phosphoribosyltransferase (OPRT) inhibitor, which together mitigate gastrointestinal and myelosuppressive toxicities associated with traditional 5-FU therapy. DFP-11207 is primarily utilized in cancer research, providing insights into more effective and safer chemotherapeutic strategies.
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