Fig. 1 · Structure
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Crizotinib-d5
Stable Isotope
Crizotinib-d5 is a deuterium-labeled form of Crizotinib, a selective and potent inhibitor of the anaplastic lymphoma kinase (ALK) and c-Met targets. With IC50 values of 20 nM and 8 nM, respectively, Crizotinib-d5 effectively inhibits tyrosine phosphorylation of both NPM-ALK and c-Met in cellular assays, demonstrating anticancer activity. This compound is utilized in research applications to study its role in tumor growth inhibition and the mechanistic pathways involved in ALK- and c-Met-mediated signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1395950-84-1 |
| Applications | Stable Isotope |
| Formula | C21H17D5Cl2FN5O |
| Molecular Weight | 455.37 |
| Synonyms | PF-02341066-d5 |
| SMILES | NC1=C(C=C(C=N1)C2=CN(N=C2)C3(C([2H])(CNCC3([2H])[2H])[2H])[2H])O[C@H](C)C4=C(C=CC(F)=C4Cl)Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.