Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Udenafil-d7 is a deuterium-labeled analogue of Udenafil, a selective and potent inhibitor of phosphodiesterase type 5 (PDE5). This stable isotope enhances the study of Udenafil's pharmacokinetics and metabolism through isotopic labeling techniques. Udenafil-d7 is primarily used in research related to erectile dysfunction and serves as a valuable tool for elucidating the molecular mechanisms underlying PDE5 inhibition. -
Stable Isotope
N-Desmethyl Sildenafil-d8 is a deuterium-labeled form of N-Desmethyl Sildenafil, a significant metabolite of Sildenafil. This compound acts primarily as a potent inhibitor of phosphodiesterase type 5 (PDE5), which plays a critical role in regulating nitric oxide signaling pathways. N-Desmethyl Sildenafil-d8 is useful in pharmacokinetic studies and metabolic research, providing insights into the metabolism and biological activity of Sildenafil in various biological systems. -
Stable Isotope
Xanthoanthrafil-d3 is a deuterium-labeled derivative of Xanthoanthrafil, a selective inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 3.95 ng/mL. This reagent is primarily utilized in studies related to erectile dysfunction, facilitating research on PDE5 inhibition and its physiological implications. The stable isotope labeling enhances the compound's tracing capabilities in biochemical studies, making it a valuable tool for researchers investigating the pharmacodynamics and pharmacokinetics of PDE5 inhibitors. -
Stable Isotope
Roflumilast-d3 is a deuterium-labeled derivative of Roflumilast, a selective phosphodiesterase 4 (PDE4) inhibitor. It exhibits high specificity with IC50 values of 0.7 nM for PDE4A1, 0.9 nM for PDE4A, 0.7 nM for PDEB1, and 0.2 nM for PDEB2, while showing no inhibition on PDE1, PDE2, PDE3, or PDE5 isoenzymes. This stable isotope is valuable for research applications involving the study of PDE4-dependent signaling pathways and drug metabolism. -
Stable Isotope
Ibudilast-d7 is a deuterium-labeled derivative of Ibudilast, a selective phosphodiesterase (PDE) inhibitor that modulates cyclic AMP levels. This compound exhibits notable platelet anti-aggregatory effects and is relevant in asthma research due to its inhibitory impact on tracheal smooth muscle contractility. Furthermore, Ibudilast is investigated for its potential neuroprotective and anti-dementia properties, particularly in countering neurotoxicity associated with activated microglia. -
Stable Isotope
Ibudilast-d7-1 is a stable isotope-labeled derivative of Ibudilast, a known phosphodiesterase (PDE) inhibitor that modulates cyclic AMP levels. It exhibits platelet anti-aggregatory properties and is utilized in research concerning asthma, particularly for its inhibitory effects on tracheal smooth muscle contraction. Additionally, Ibudilast has potential neuroprotective effects and may serve as an anti-dementia agent by mitigating neurotoxicity in activated microglia. -
Stable Isotope
Vardenafil-d5 is a deuterium-labeled derivative of Vardenafil, a potent and selective inhibitor of phosphodiesterase-5 (PDE5) with an IC50 of 0.7 nM. It exhibits high selectivity for PDE5 over other phosphodiesterases, including PDE1 (180 nM) and PDE6 (11 nM). By competitively inhibiting the hydrolysis of cyclic guanosine monophosphate (cGMP), Vardenafil-d5 effectively elevates cGMP levels. This reagent is valuable for research applications related to erectile dysfunction. -
Stable Isotope
Milrinone-d3 is a deuterium-labeled derivative of Milrinone, primarily targeting phosphodiesterase 3 (PDE3). This compound functions as both an inotropic agent and a vasodilator, enhancing cardiac contractility and promoting vascular relaxation. Milrinone-d3 is valuable for studies involving drug metabolism, pharmacokinetics, and the mechanistic exploration of PDE3 inhibition in cardiovascular research. -
Stable Isotope
Flavoxate-d5 is a deuterated analog of Flavoxate, serving as a stable isotope. This compound is primarily utilized in pharmacokinetic studies and analytical chemistry to trace metabolic pathways, as well as in the investigation of drug interactions. Its unique isotopic labeling facilitates higher precision in mass spectrometry applications, enhancing the understanding of Flavoxate's biological activity and pharmacological profile. -
Stable Isotope
Vinpocetine-d5 is a deuterium-labeled derivative of Vinpocetine, which primarily inhibits voltage-gated sodium channels. It serves as a phosphodiesterase (PDE) inhibitor, effectively disrupting NF-κB-dependent inflammatory responses by directly targeting the IκB kinase complex (IKK), with an IC50 of 17.17 μM in a cell-free system. This compound is valuable in research related to cerebrovascular disorders and inflammation, enabling the tracking and analysis of Vinpocetine's biological effects in various applications. -
Stable Isotope
Crisaborole-d4 is a deuterium-labeled analog of Crisaborole, a selective inhibitor of phosphodiesterase 4 (PDE4). This compound exhibits potent pharmacological activity, demonstrated by its ability to inhibit PDE4 with an IC50 of 0.49 μM, leading to reduced cytokine release. Crisaborole-d4 can be utilized in biochemical research to study PDE4-related pathways and the role of cyclic AMP in inflammation and immune responses. -
Stable Isotope
Avanafil-13C,d3 is a stable isotope-labeled analog of Avanafil, incorporating both carbon-13 and deuterium isotopes. This compound is designed for use in pharmacokinetic studies and metabolic research, allowing for the precise tracking of compound distribution and metabolism in biological systems. Its stable isotopic labeling enhances the accuracy of analytical methods, facilitating detailed investigations into the pharmacodynamics and biochemical pathways associated with Avanafil. -
Stable Isotope
Triflusal-d3 is a deuterated derivative of Triflusal that serves as a stable isotope for analytical research. It functions as a dual inhibitor of Cyclooxygenase-1 (COX-1) and cAMP phosphodiesterase, demonstrating significant anti-inflammatory properties by inhibiting platelet aggregation and prostaglandin synthesis in ischemic tissues. Triflusal-d3 also enhances neutrophil nitric oxide production and promotes endothelial nitric oxide synthase (eNOS) expression. Its applications extend to the study of thromboembolic and ischemic cardiovascular diseases, as well as Alzheimer's disease models, providing insights into neurological and vascular pathologies. -
Stable Isotope
Exatecan-d5 mesylate is a deuterium-labeled derivative of Exatecan mesylate, functioning as a selective DNA topoisomerase I inhibitor. With an IC50 value of 2.2 μM, it effectively interferes with DNA replication and transcription processes. This reagent is valuable for cancer research, particularly in studies evaluating the mechanisms of action and resistance related to topoisomerase I-targeted therapies. -
Stable Isotope
Paclitaxel-d5 is a deuterium-labeled derivative of Paclitaxel, a potent antineoplastic agent that promotes the stabilization of tubulin polymerization. This stable isotope variant is primarily utilized in pharmacokinetic studies to trace the metabolism and distribution of Paclitaxel in biological systems. Its application is essential for understanding the compound's therapeutic dynamics and potential interactions in oncology research. -
Stable Isotope
Exatecan Intermediate 1-d5 is a deuterium-labeled derivative of Exatecan Intermediate 1, designed for use as a stable isotope in various biochemical studies. This compound serves as a valuable tool in pharmacokinetic and metabolic research, allowing for enhanced tracking of drug metabolism and distribution in biological systems. Its isotopic labeling aids in quantitative analysis and helps elucidate molecular interactions, making it a crucial reagent in the investigation of antitumor agents and related therapeutics. -
Stable Isotope
Epalrestat-d5 is a deuterium-labeled derivative of Epalrestat, which functions as an orally active aldose reductase inhibitor. This compound primarily targets the aldose reductase enzyme involved in the glucose metabolism pathway, making it relevant in the study of diabetic neuropathy. Epalrestat-d5 is useful in pharmacokinetic studies and metabolic research that require stable isotope labeling for precise analysis. -
Stable Isotope
Haloxyfop-d4 is a deuterium-labeled derivative of Haloxyfop, an aryloxyphenoxypropionic acid herbicide. Its primary mechanism involves the inhibition of acetyl coenzyme A carboxylase (EC 6.4.1.2), demonstrating an IC50 of 0.5 μM in corn seedling chloroplasts. This compound is utilized in chemical research to investigate herbicide action and metabolic pathways, particularly in studies focusing on weed control in broad-leaf crops. -
Stable Isotope
Cromolyn-d5, a deuterium-labeled derivative of Cromolyn, serves as a stable isotope for research applications. As an orally active inhibitor of GSK-3β with an IC50 of 2.0 μM, Cromolyn exhibits significant biological activity as a mast cell stabilizer, effectively inhibiting the release of mediators and regulating bronchial hyperreactivity. Its utility extends to bronchial asthma research, alongside additional effects including anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective properties. -
Stable Isotope
AR-A014418-d3 is a deuterium-labeled analogue of the selective GSK3β inhibitor AR-A014418. It exhibits potent ATP-competitive inhibition with an IC50 of 104 nM and a Ki of 38 nM. This stable isotope form is useful for tracking and quantifying GSK3β activity in biological systems, and it serves as a valuable tool in research focused on cellular signaling, metabolism, and neurodegenerative diseases. -
Stable Isotope
Desmethyl Levofloxacin-d8 is a deuterated form of Desmethyl Levofloxacin, a key metabolite of Levofloxacin. This synthetic fluoroquinolone antibiotic exerts its biological activity by inhibiting bacterial DNA gyrase, thereby disrupting DNA supercoiling and interfering with DNA replication. Desmethyl Levofloxacin-d8 serves as a valuable stable isotope labeled reagent for pharmacokinetic studies and analytical applications in drug metabolism research. -
Stable Isotope
Sulfanilamide-d4 is a stable isotope-labeled derivative of sulfanilamide, specifically designed for quantitative studies. As a competitive inhibitor of the bacterial enzyme dihydropteroate synthetase, sulfanilamide-d4 demonstrates an IC50 of 320 μM. This reagent is utilized in biochemical research to trace metabolic pathways and assess the activity of dihydropteroate synthetase in microbial systems. -
Stable Isotope
Valacyclovir-d8 hydrochloride is a deuterated analog of Valacyclovir hydrochloride, serving as a stable isotope for advanced research applications. This compound exhibits potent antiviral activity against herpes simplex virus type 1 (HSV-1) with an IC50 of 2.9 μg/ml, making it a valuable tool in studying viral infections. Valacyclovir functions as a prodrug of Acyclovir, facilitating studies on pharmacokinetics and metabolism in virology and clinical research contexts. -
Stable Isotope
2-Thiophenecarboxaldehyde-d3 is a deuterium-labeled derivative of 2-Thiophenecarboxaldehyde. This stable isotope is used as an internal standard in analytical chemistry and pharmacokinetic studies. Its primary application lies in the investigation of antibacterial and nematicidal properties, contributing valuable insights to chemical research in microbiology and pest control. -
Stable Isotope
Sarafloxacin-d8 hydrochloride is a deuterium-labeled derivative of the quinolone antibiotic Sarafloxacin. This stable isotope reagent enables investigations into the drug's pharmacokinetics and metabolic pathways. It is widely applicable in tracing studies and mass spectrometry, facilitating enhanced understanding of antibiotic behavior in biological systems. -
Stable Isotope
Nitrofurantoin-13C3 is a stable isotope-labeled form of Nitrofurantoin, a broad-spectrum antimicrobial agent known for its effectiveness against beta-lactamase-producing bacteria. This compound functions as an antibiotic, primarily employed in the study and treatment of urinary tract infections (UTIs), including cystitis and pyelonephritis. The stable isotope labeling allows for enhanced tracking and quantification in pharmacokinetic and metabolic studies. -
Stable Isotope
Moxifloxacin-d3-1 hydrochloride is a deuterium-labeled derivative of Moxifloxacin, an 8-methoxyquinolone antibiotic. This stable isotope serves as a valuable analytical tool in pharmacokinetic studies and metabolic profiling of Moxifloxacin. It is particularly useful in research applications focused on understanding the drug's metabolic pathways, efficacy against bacterial infections, and its role in treating conditions such as acute bacterial sinusitis and community-acquired pneumonia. -
Stable Isotope
Flumequine-13C3 is a stable isotope-labeled variant of flumequine, a quinolone antibiotic known for its ability to inhibit topoisomerase II with an IC50 of 15 μM (3.92 μg/mL). This compound is essential for research involving metabolic studies and drug metabolism, enabling precise tracking and analysis of flumequine's biochemical interactions within biological systems. Its stable isotope label makes it particularly useful in mass spectrometry applications and pharmacokinetic studies. -
Stable Isotope
2-(α-D-Mannopyranosyl)-L-tryptophan-d4 is a stable isotope-labeled derivative of 2-(α-D-Mannopyranosyl)-L-tryptophan, facilitating enhanced analysis in metabolic studies. This compound serves as a valuable tool for tracing metabolic pathways and studying glycoprotein interactions in biochemical research. Its deuterium labeling aids in quantifying and tracking molecules in complex biological systems, making it an essential reagent for researchers in the fields of glycoscience and pharmacology. -
Stable Isotope
Sulfamonomethoxine-d3-1 is a deuterium-labeled derivative of Sulfamonomethoxine, functioning primarily as a stable isotope. This compound serves as an orally active sulfonamide antibiotic utilized in veterinary medicine, exhibiting antibacterial activity. By inhibiting dihydropteroate synthetase, Sulfamonomethoxine-d3-1 effectively disrupts folic acid synthesis, making it a valuable reagent for research applications involving antibiotic activity and metabolic studies. -
Stable Isotope
Moxifloxacin-d3 hydrochloride is a deuterium-labeled derivative of the antibiotic Moxifloxacin hydrochloride, designed for stable isotope applications in research. This compound retains the antimicrobial activity of the original Moxifloxacin, which is effective in treating infections such as acute bacterial sinusitis, exacerbations of chronic bronchitis, and community-acquired pneumonia. Moxifloxacin-d3 hydrochloride is valuable for pharmacokinetic studies and metabolic research involving isotopic tracing. -
Stable Isotope
Ertapenem-d4 is a deuterium-labeled derivative of the broad-spectrum β-lactam antibiotic Ertapenem. This compound exhibits potent antibacterial activity, particularly against a variety of anaerobic bacteria, with a minimum inhibitory concentration (MIC) of 0.12 μg/mL. Ertapenem-d4 is useful in research applications focused on the pharmacokinetics and metabolic pathways of β-lactam antibiotics, as well as studies involving severe bacterial infections in diverse anatomical sites including the skin, lungs, stomach, pelvis, and urinary tract. -
Stable Isotope
Aprepitant-13C2,d2 (Major) is a stable isotope-labeled variant of Aprepitant, a selective and high-affinity antagonist of the neurokinin 1 receptor with a dissociation constant (Kd) of 86 pM. This reagent is primarily utilized in pharmacokinetic studies and metabolic research. The 13C labeling allows for precise tracing and quantification in complex biological systems, facilitating a deeper understanding of Aprepitant's biochemical interactions and tissue distribution. -
Stable Isotope
Tiamulin-d10-1 hydrochloride is a deuterium-labeled derivative of the diterpenic antibiotic Tiamulin. Its primary mechanism targets bacterial protein synthesis, making it crucial in research involving infectious diseases in livestock, particularly in the control of Mycoplasma spp. Tiamulin is commonly utilized in studies of airsacculitis, facilitating enhanced understanding of antibiotic efficacy and resistance mechanisms in veterinary medicine. -
Stable Isotope
Gatifloxacin-d4 hydrochloride is a deuterium-labeled analog of Gatifloxacin, primarily utilized as a stable isotope in chemical and biological research. This reagent is valuable for pharmacokinetic studies, metabolic profiling, and trace analysis in complex biological matrices. Its incorporation of deuterium allows for enhanced detection and quantification in mass spectrometry applications, facilitating the study of drug interactions and metabolic pathways. -
Stable Isotope
(R)-2-Methylbutanoic acid-d3 is a deuterium-labeled derivative of (R)-2-Methylbutanoic acid, serving as a stable isotope used in various research applications. This compound aids in metabolic studies, trace analysis, and isotope labeling experiments, allowing for enhanced sensitivity and specificity in quantitative analysis. Its use in nuclear magnetic resonance (NMR) and mass spectrometry provides valuable tools for probing biochemical pathways and mechanisms. -
Stable Isotope
Sulfisomidin-d4 is a deuterium-labeled derivative of Sulfisomidin, a sulfonamide antibacterial with oral bioavailability. This compound primarily targets bacterial dihydropteroate synthase, inhibiting folate synthesis and demonstrating antibacterial activity. Sulfisomidin-d4 is useful for research applications involving lower urinary tract infections, providing a valuable tool for studying pharmacokinetics and metabolic pathways of sulfonamide antibiotics. -
Stable Isotope
(Rac)-Moxifloxacin-d4 is a deuterium-labeled derivative of (Rac)-Moxifloxacin, an 8-methoxyquinolone antimicrobial. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research to trace and quantify the drug's behavior in biological systems. Its applications extend to investigating the efficacy of antibacterial therapies against pathogens responsible for respiratory infections, such as acute bacterial sinusitis and pneumonia. -
Stable Isotope
Moxifloxacin-d5 is a deuterium-labeled derivative of Moxifloxacin, an 8-methoxyquinolone antibiotic. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace the behavior of Moxifloxacin in biological systems. It is particularly relevant for investigations into its action against acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia. -
Stable Isotope
Nalidixic Acid-d5 is a deuterium-labeled derivative of nalidixic acid, a quinolone antibiotic that targets DNA gyrase and topoisomerase IV. This compound exhibits bacteriostatic activity at lower concentrations and demonstrates bactericidal effects at higher concentrations against a broad spectrum of gram-positive and gram-negative bacteria. Nalidixic Acid-d5 is utilized in research applications involving antibiotic resistance studies, bacterial DNA replication mechanisms, and pharmacokinetic investigations. -
Stable Isotope
ent-Florfenicol-d3 is a deuterium-labeled analog of the antibiotic Florfenicol, primarily known for its application in veterinary medicine. This compound is indicated for the treatment of bovine respiratory disease and has utility in aquaculture for managing enteric septicemia in fish species. Research has shown that Florfenicol can induce early embryonic death in eggs, with a lethal concentration (LC50) of 1.07 μg/g, making this labeled reagent valuable for pharmacokinetic studies and environmental impact research. -
Stable Isotope
Cefprozil-d4 is a deuterium-labeled analog of Cefprozil, a second-generation cephalosporin antibiotic. This stable isotope exhibits broad-spectrum antibacterial activity and is effective for oral administration. Cefprozil-d4 is suitable for research applications involving the investigation of pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections, aiding in the study of therapeutic efficacy and pharmacokinetics. -
Stable Isotope
L-Lactic acid-13C3 is a stable isotope form of L-Lactic acid, labeled with carbon-13. It serves as a valuable tool for investigating lactate metabolism in various biological systems. This compound is particularly useful in metabolic studies, allowing researchers to trace metabolic pathways and analyze lactate dynamics in cellular and tissue samples. -
Stable Isotope
L-Lactic acid-13C3 sodium is a stable isotope of L-Lactic acid that serves as a valuable tool for studying lactate metabolism. This compound enables precise tracking of metabolic pathways and investigation of physiological processes involving lactate. Its applications include metabolic research, isotopic labeling studies, and investigations into energy production and exercise physiology. This reagent is provided at a concentration of 20% w/w in water, facilitating its integration into diverse experimental protocols. -
Stable Isotope
Fenbendazole-d3 is a deuterium-labeled derivative of the anthelmintic agent Fenbendazole, targeting microtubules to destabilize their structure. This compound acts as a HIF-1α agonist, thereby activating the HIF-1α-mediated GLUT1 signaling pathway. Fenbendazole exhibits cell-cycle arrest and induces mitotic cell death, demonstrating significant antitumor activity in xenograft models using wild-type p53. Research applications include studies on cancer biology, parasitology, and mechanisms of cellular stress response. -
Stable Isotope
Meropenem-d6 is the deuterated form of the carbapenem antibiotic Meropenem, which exhibits broad-spectrum antibacterial activity. This stable isotope is particularly effective against susceptible and resistant strains of Neisseria gonorrhoeae, with minimum inhibitory concentration (MIC) values ranging from 0.02 to 0.06 mg/mL, as well as Haemophilus influenzae and Haemophilus ducreyi, with MIC values of 0.03 to 0.12 mg/mL and 0.015 to 0.12 mg/mL, respectively. Meropenem-d6 is valuable for pharmacokinetic studies and metabolic tracing in biological research. -
Stable Isotope
Sulfamethoxazole-d4 is a deuterium-labeled derivative of the sulfonamide antibiotic, Sulfamethoxazole. This compound functions by inhibiting bacterial folate metabolism through competitive inhibition of dihydropteroate synthetase and dihydropteroate reductase, targeting the enzyme's interaction with 4-Aminobenzoic acid (PABA). Sulfamethoxazole-d4 is valuable in pharmacokinetic studies and can aid in research related to urinary tract infections, prostatitis, and bronchitis. -
Stable Isotope
Trimethoprim-d9 is a deuterated form of Trimethoprim, a known bacteriostatic antibiotic that functions primarily as a dihydrofolate reductase inhibitor. This stable isotope retains the biological activity of its non-labeled counterpart, demonstrating efficacy against numerous Gram-positive and Gram-negative aerobic bacteria. Trimethoprim-d9 is valuable for research applications involving pharmacokinetic studies, metabolic profiling, and tracing pathways of antibiotic action. -
Stable Isotope
Levofloxacin-d8 is a deuterated form of levofloxacin, a synthetic fluoroquinolone antibiotic. It primarily targets bacterial DNA gyrase, inhibiting its supercoiling activity and consequently halting DNA replication. This isotopically labeled reagent is suitable for studies involving metabolic tracking and pharmacokinetic analysis in bacterial systems, aiding in the understanding of antibiotic efficacy and resistance mechanisms. -
Stable Isotope
Linezolid-d3 is a deuterium-labeled derivative of Linezolid, a synthetic antibiotic that targets bacterial protein synthesis by inhibiting its initiation. This stable isotope is valuable for pharmacokinetic studies and metabolic research, allowing for precise tracking and quantification of drug metabolism and distribution in biological systems. Its application extends to drug development and the exploration of antimicrobial resistance mechanisms, enhancing the understanding of bacterial protein synthesis inhibition.
