Sorafenib-d3 tosylate is a deuterium-labeled derivative of Sorafenib, a potent multikinase inhibitor primarily targeting Raf, VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit with respective IC50 values of 6 nM, 20 nM, 90 nM, 15 nM, 57 nM, and 58 nM. It exhibits notable biological activities, including the induction of autophagy and apoptosis, contributing to its anti-tumor efficacy. Sorafenib-d3 tosylate serves as a valuable tool for research applications focusing on cancer biology, signaling pathways, and ferroptosis mechanisms.
Sorafenib-d3 tosylate is a deuterium-labeled derivative of Sorafenib, a potent multikinase inhibitor primarily targeting Raf, VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit with respective IC50 values of 6 nM, 20 nM, 90 nM, 15 nM, 57 nM, and 58 nM. It exhibits notable biological activities, including the induction of autophagy and apoptosis, contributing to its anti-tumor efficacy. Sorafenib-d3 tosylate serves as a valuable tool for research applications focusing on cancer biology, signaling pathways, and ferroptosis mechanisms.
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