Amodiaquine-d10 is a deuterium-labeled analog of Amodiaquine, a 4-aminoquinoline antimalarial agent. This compound functions primarily as a histamine N-methyltransferase inhibitor and demonstrates activity as a Nurr1 agonist, selectively binding to the Nurr1 ligand-binding domain with an EC50 of approximately 20 μM. Amodiaquine-d10 is valuable for research applications in studying malaria mechanisms, anti-inflammatory pathways, and the role of Nurr1 in cellular processes.
Amodiaquine-d10 is a deuterium-labeled analog of Amodiaquine, a 4-aminoquinoline antimalarial agent. This compound functions primarily as a histamine N-methyltransferase inhibitor and demonstrates activity as a Nurr1 agonist, selectively binding to the Nurr1 ligand-binding domain with an EC50 of approximately 20 μM. Amodiaquine-d10 is valuable for research applications in studying malaria mechanisms, anti-inflammatory pathways, and the role of Nurr1 in cellular processes.
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