Lapatinib-d4-1 is a deuterium-labeled derivative of Lapatinib, which primarily targets the ErbB-2 and EGFR tyrosine kinase domains. It exhibits strong inhibition with IC50 values of 10.2 nM for EGFR and 9.8 nM for ErbB-2. This stable isotope-labeled compound is valuable for pharmacokinetic studies and provides insights into drug metabolism, distribution, and bioavailability in chemical research applications.
Lapatinib-d4-1 is a deuterium-labeled derivative of Lapatinib, which primarily targets the ErbB-2 and EGFR tyrosine kinase domains. It exhibits strong inhibition with IC50 values of 10.2 nM for EGFR and 9.8 nM for ErbB-2. This stable isotope-labeled compound is valuable for pharmacokinetic studies and provides insights into drug metabolism, distribution, and bioavailability in chemical research applications.
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