Fig. 1 · Structure
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Physostigmine-d3
Stable Isotope
Physostigmine-d3 is the deuterated form of Physostigmine, a reversible inhibitor of acetylcholinesterase (AChE). This compound effectively crosses the blood-brain barrier, enhancing central cholinergic neurotransmission, and is utilized in research for its ability to reverse memory deficits in transgenic mouse models of Alzheimer's disease. Additionally, Physostigmine serves as an antidote for anticholinergic poisoning, making it significant for studies in neuropharmacology and toxicology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1217704-11-4 |
| Applications | Stable Isotope |
| Formula | C15H18D3N3O2 |
| Molecular Weight | 278.36 |
| Synonyms | Eserine-d3 |
| SMILES | C[C@]12C3=CC(OC(NC([2H])([2H])[2H])=O)=CC=C3N([C@@]1([H])N(CC2)C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.