Dabigatran-d3 is a deuterium-labeled form of Dabigatran, a potent and reversible direct thrombin inhibitor with a Ki of 4.5 nM. This isotope-labeled reagent retains the pharmacological properties of its non-labeled counterpart, effectively inhibiting thrombin-induced platelet aggregation with an IC50 of 10 nM. Dabigatran-d3 is primarily utilized in pharmacokinetic studies and metabolic research, facilitating the investigation of the drug's behavior in biological systems.
Dabigatran-d3 is a deuterium-labeled form of Dabigatran, a potent and reversible direct thrombin inhibitor with a Ki of 4.5 nM. This isotope-labeled reagent retains the pharmacological properties of its non-labeled counterpart, effectively inhibiting thrombin-induced platelet aggregation with an IC50 of 10 nM. Dabigatran-d3 is primarily utilized in pharmacokinetic studies and metabolic research, facilitating the investigation of the drug's behavior in biological systems.
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