Fig. 1 · Structure
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Donepezil-d5 hydrochloride
Stable Isotope
Donepezil-d5 hydrochloride is a stable deuterium-labeled analogue of Donepezil, which acts as a reversible and selective inhibitor of acetylcholinesterase (AChE) with an IC50 value of 6.7 nM. Its high selectivity for AChE over butyrylcholinesterase (BuChE) makes it a valuable tool in studying cholinergic signaling. Donepezil-d5 also demonstrates neuroprotective effects against Aβ42-induced neurotoxicity, making it relevant in Alzheimer's disease research and other neurodegenerative studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1883548-90-0 |
| Applications | Stable Isotope |
| Formula | C24H25D5ClNO3 |
| Molecular Weight | 420.98 |
| Synonyms | E2020-d5 |
| SMILES | O=C1C(CC2=CC(OC)=C(C=C21)OC)CC3CCN(CC3)CC4=C(C([2H])=C(C([2H])=C4[2H])[2H])[2H].Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.