Donepezil-d5 hydrochloride is a stable deuterium-labeled analogue of Donepezil, which acts as a reversible and selective inhibitor of acetylcholinesterase (AChE) with an IC50 value of 6.7 nM. Its high selectivity for AChE over butyrylcholinesterase (BuChE) makes it a valuable tool in studying cholinergic signaling. Donepezil-d5 also demonstrates neuroprotective effects against Aβ42-induced neurotoxicity, making it relevant in Alzheimer's disease research and other neurodegenerative studies.
Donepezil-d5 hydrochloride is a stable deuterium-labeled analogue of Donepezil, which acts as a reversible and selective inhibitor of acetylcholinesterase (AChE) with an IC50 value of 6.7 nM. Its high selectivity for AChE over butyrylcholinesterase (BuChE) makes it a valuable tool in studying cholinergic signaling. Donepezil-d5 also demonstrates neuroprotective effects against Aβ42-induced neurotoxicity, making it relevant in Alzheimer's disease research and other neurodegenerative studies.
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