Donepezil-d4 hydrochloride is a deuterium-labeled derivative of Donepezil hydrochloride, a reversible and selective inhibitor of acetylcholinesterase (AChE) with an IC50 of 6.7 nM. This compound demonstrates a strong selectivity for AChE over butyrylcholinesterase (BuChE) and exhibits neuroprotective effects against Aβ42-induced neurotoxicity. Donepezil-d4 is valuable for studying AChE interactions and pharmacokinetics in neurodegenerative disease research.
Donepezil-d4 hydrochloride is a deuterium-labeled derivative of Donepezil hydrochloride, a reversible and selective inhibitor of acetylcholinesterase (AChE) with an IC50 of 6.7 nM. This compound demonstrates a strong selectivity for AChE over butyrylcholinesterase (BuChE) and exhibits neuroprotective effects against Aβ42-induced neurotoxicity. Donepezil-d4 is valuable for studying AChE interactions and pharmacokinetics in neurodegenerative disease research.
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