Donepezil-d5 is a deuterium-labeled form of Donepezil, a potent and selective inhibitor of acetylcholinesterase (AChE). It demonstrates inhibitory activities with IC50 values of 8.12 nM for bovine AChE and 11.6 nM for human AChE. This stable isotope is valuable for pharmacokinetic studies and metabolic profiling in research related to neurodegenerative diseases, particularly Alzheimer's disease.
Donepezil-d5 is a deuterium-labeled form of Donepezil, a potent and selective inhibitor of acetylcholinesterase (AChE). It demonstrates inhibitory activities with IC50 values of 8.12 nM for bovine AChE and 11.6 nM for human AChE. This stable isotope is valuable for pharmacokinetic studies and metabolic profiling in research related to neurodegenerative diseases, particularly Alzheimer's disease.
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