Fig. 1 · Structure
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Donepezil-d5
Stable Isotope
Donepezil-d5 is a deuterium-labeled form of Donepezil, a potent and selective inhibitor of acetylcholinesterase (AChE). It demonstrates inhibitory activities with IC50 values of 8.12 nM for bovine AChE and 11.6 nM for human AChE. This stable isotope is valuable for pharmacokinetic studies and metabolic profiling in research related to neurodegenerative diseases, particularly Alzheimer's disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1128086-25-8 |
| Applications | Stable Isotope |
| Formula | C24H24D5NO3 |
| Molecular Weight | 384.52 |
| Synonyms | E2020-d5 free base |
| SMILES | O=C1C2=CC(OC)=C(OC)C=C2CC1CC3CCN(CC3)CC4=C([2H])C([2H])=C([2H])C([2H])=C4[2H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.