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Catalog No.
Product Name
Application
Product Information
Citations
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JAK Inhibitor
Pumecitinib is a selective Janus kinase (JAK) inhibitor that exhibits significant anti-inflammatory activity. By targeting the JAK signaling pathway, it has been shown to modulate immune responses and reduce inflammation. This compound is valuable for research into inflammatory diseases and conditions driven by aberrant JAK signaling. -
ITK/JAK3 Inhibitor
Modzatinib is a selective, covalent inhibitor targeting ITK and JAK3, demonstrating IC50 values of 8 nM and 23 nM, respectively. Its potent anti-inflammatory properties make it a valuable tool for research in autoimmune and inflammatory diseases, facilitating the exploration of therapeutic interventions in these areas. Researchers can leverage modzatinib to study the mechanistic roles of ITK and JAK3 in immune responses and disease pathology. -
JAK1 Inhibitor
GS-829845 is a JAK1 inhibitor that serves as a significant active metabolite of Filgotinib. This compound preferentially inhibits JAK1, exhibiting approximately 10-fold lower potency than its parent compound while demonstrating an extended half-life. GS-829845 is primarily utilized in research related to autoimmune disorders and other inflammatory conditions, contributing to the understanding of JAK pathway modulation in therapeutic applications. -
JAK1 Inhibitor
GDC-4379 is a selective inhibitor of JAK1, a key enzyme involved in the signaling pathways of various cytokines. This compound demonstrates significant biological activity in the modulation of immune responses, making it relevant for research applications in asthma and other inflammatory diseases. Its ability to inhibit JAK1 signaling offers insights into the therapeutic potential for treating pathologies associated with dysregulated immune function. -
Type II JAK2 Inhibitor
YLIU-4-105-1 is a Type II JAK2 inhibitor that selectively targets the ATP-binding pocket of the JH1 domain. This compound demonstrates significant biological activity, effectively inhibiting phosphorylated STAT5 (pSTAT5) signaling pathways. Research applications include studies on myeloproliferative neoplasms and other diseases associated with JAK2 mutations, with in vivo pharmacodynamic effects such as reduction in spleen-to-body weight ratio and decreased blood reticulocyte counts observed in a dose-dependent manner. -
JAK1/2 inhibitor
iJak-381 is a selective inhibitor of JAK1 and JAK2, exhibiting significant anti-inflammatory properties. This compound effectively disrupts IL-13 signaling, along with inhibiting the IL-4 and IL-6 pathways, leading to a reduction in phosphorylated STAT6 levels. Additionally, iJak-381 demonstrates the ability to diminish the influx of inflammatory cells in the lungs of murine models, thereby alleviating airway hyperresponsiveness (AHR). It serves as a valuable tool for research into therapeutic strategies targeting inflammatory diseases. -
JAK Inhibitor
JAK-IN-20 is a potent, pan-selective Janus kinase (JAK) inhibitor, exhibiting IC50 values of 7 nM, 5 nM, and 14 nM for JAK1, JAK2, and JAK3, respectively. This orally active compound demonstrates favorable pharmacokinetic properties and exerts significant anti-inflammatory effects in vivo. JAK-IN-20 is suitable for research applications targeting JAK signaling pathways, particularly in the contexts of autoimmune diseases and chronic inflammation. -
JAK Inhibitor
Nimucitinib is a Janus kinase (JAK) inhibitor that interferes with the JAK-STAT signaling pathway. It exhibits anti-inflammatory properties and is utilized in various research applications, including the study of autoimmune diseases and inflammatory conditions. Nimucitinib's ability to modulate cytokine signaling makes it a valuable tool for investigating therapeutic strategies in hematological and oncological research. -
JAK2/STAT3 Inhibitor
SD-1029 is a selective JAK2/STAT3 inhibitor that impedes the phosphorylation of JAK2, thereby obstructing STAT3 activation. By inhibiting STAT3 nuclear translocation, SD-1029 serves as a valuable tool for studying the JAK2/STAT3 signaling pathway. This compound is relevant in research applications involving cancer, autoimmune disorders, and other diseases associated with dysregulated STAT3 activity. -
JAK3 Inhibitor
JAK 3i is a highly selective inhibitor of JAK3, exhibiting an IC50 of 0.43 nM. It forms a covalent bond with a specific cysteine residue in the JAK3 kinase domain, demonstrating minimal interaction with JAK1, JAK2, or TYK2. JAK 3i effectively inhibits IL-2-driven T-cell proliferation in vivo, making it a valuable tool for research applications in autoimmune diseases and related therapeutic studies. -
Tubulin/JAK2-IN-1 inhibitor, Antitumor
Tubulin/JAK2-IN-1 is a dual inhibitor targeting Janus kinase 2 (JAK2) and microtubules, exhibiting potent antitumor activity. This compound demonstrates significant antiproliferative effects against various cancer cell lines, making it a valuable tool in cancer research. Its dual mechanism of action supports investigations into therapies that disrupt cell division and signaling pathways in malignancies. -
JAK1 Inhibitor
Blovacitinib is a selective inhibitor of Janus kinase 1 (JAK1), demonstrating high potency with IC50 values of 3, 37, 1517, and 36 nM against JAK1, JAK2, JAK3, and TYK2, respectively. This oral agent is primarily utilized in research focused on rheumatoid arthritis, targeting inflammatory pathways associated with this condition. Its specificity for JAK1 makes it an important tool for investigating JAK-STAT signaling mechanisms in various cellular contexts. -
JAK Inhibitor
(1R)-AZD-1480 is an ATP-competitive inhibitor targeting Janus kinase 1 (JAK1) and Janus kinase 2 (JAK2). It exhibits potent inhibitory activity and is utilized in research applications focused on cytokine signaling, immune response modulation, and the investigation of various hematological malignancies. This compound serves as a valuable tool for exploring JAK-related pathways and therapeutic strategies in malignancies and autoimmune disorders. -
JAK Inhibitor
JAK-IN-11 is a potent and selective Janus kinase (JAK) inhibitor designed for the treatment of skin disorders, including cutaneous lupus. This compound exhibits significant biological activity by modulating JAK signaling pathways, making it a valuable tool for research in inflammatory conditions. Additionally, JAK-IN-11 functions as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating its application in chemical biology studies. -
JAK Inhibitor
JAK-IN-10 is a selective Janus kinase (JAK) inhibitor that modulates inflammatory pathways by inhibiting JAK signaling. It is particularly valuable in the study of dry eye disorders, providing insights into the underlying mechanisms of inflammation. Additionally, JAK-IN-10 features an alkyne functional group and is suitable for click chemistry applications, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing compounds. This property enhances its utility in chemical biology and medicinal chemistry research. -
JAK Inhibitor
Frevecitinib is a potent pan-JAK inhibitor, targeting JAK1, JAK2, JAK3, and TYK2. This compound is useful for investigating mechanisms involved in asthma and other respiratory conditions, including chronic obstructive pulmonary disease (COPD). Its ability to modulate JAK signaling pathways makes it a valuable tool in research focused on inflammatory diseases and immune response. -
JAK2 Inhibitor
JAK-IN-35 is a selective JAK2 inhibitor that targets the Janus kinase 2 enzyme. This compound demonstrates significant anti-proliferative activity in various cancer cells, making it a valuable tool for cancer research. Its ability to modulate JAK2 signaling pathways can aid in the exploration of therapeutic strategies for malignancies driven by aberrant JAK2 activity. -
JAK Inhibitor
JAK-IN-26 is an orally active Janus kinase (JAK) inhibitor that effectively targets the JAK-STAT signaling pathway. It demonstrates significant inhibitory activity on IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells, with an IC50 value of 17.2 nM. This compound is valuable for research applications focused on cytokine signaling, immune response modulation, and the study of JAK-related signaling pathways in various disease contexts. -
JAK1 Inhibitor
JAK-IN-14 is a selective inhibitor of Janus kinase 1 (JAK1), exhibiting an IC50 of less than 5 μM. This compound demonstrates over eightfold selectivity for JAK1 compared to JAK2 and JAK3. JAK-IN-14 is valuable for research applications focused on elucidating the role of JAK1 in various inflammatory and autoimmune conditions. -
JAK Inhibitor
Lirucitinib is a selective JAK inhibitor with significant anti-inflammatory activity. It effectively inhibits the signaling of various cytokines involved in itch and inflammation, particularly those that rely on JAK1 enzyme activity, as well as cytokines related to allergic responses. This compound is valuable for research applications focused on pruritic skin diseases and associated inflammatory conditions. -
JAK2 V617F Inhibitor
JAK2-IN-10 is a potent inhibitor targeting the JAK2 V617F mutation, exhibiting an IC50 value of ≤10 nM. This compound demonstrates significant activity in suppressing the JAK/STAT signaling pathway, which is often dysregulated in various hematological malignancies. JAK2-IN-10 is suitable for research applications focused on understanding myeloproliferative neoplasms and developing targeted therapies. -
JAK Inhibitor
JAK-IN-21 is a selective and potent inhibitor of Janus kinase (JAK), demonstrating inhibitory concentrations (IC50) of 1.73 nM for JAK1, 2.04 nM for JAK2, 109 nM for the J2V617F mutant, and 62.9 nM for TYK2. This compound is useful in research applications focused on elucidating the role of JAK signaling pathways in various diseases, including hematological malignancies and autoimmune disorders. JAK-IN-21 serves as a valuable tool for studying the therapeutic potential of JAK inhibition. -
Tyk-2 Inhibitor
Tyk2-IN-8 is a selective inhibitor of Tyk-2, exhibiting an IC50 of 5.7 nM for TYK2-JH2 and 3.0 nM for JAK1-JH1. This compound is instrumental in investigating the role of Tyk-2 in various biological processes. Tyk2-IN-8 is particularly relevant for research focused on autoimmune diseases, enabling studies on signaling pathways involved in immune regulation and inflammation. -
Cathepsin L/JAK Inhibitor
Dual Cathepsin L/JAK-IN-1 is a dual inhibitor targeting Cathepsin L (CTSL) and Janus kinases (JAK), exhibiting IC50 values of 0.68 μM for CTSL, 337.1 nM for JAK1, 5.251 nM for JAK2, 27.29 nM for JAK3, and 172.6 nM for TYK2. This compound effectively inhibits the activation of key signaling pathways, including MAPK, NF-κB, and JAK/STAT, thereby providing substantial anti-inflammatory effects. Dual Cathepsin L/JAK-IN-1 is useful for investigating mechanisms underlying acute lung injury (ALI) and other inflammatory conditions. -
JAK1 Inhibitor
Upadacitinib tartrate tetrahydrate is a selective inhibitor of Janus kinase 1 (JAK1) with an IC50 value of 43 nM. It exhibits approximately 74-fold selectivity for JAK1 over JAK2 in assays utilizing specific cytokines. This compound is widely applicable in research focused on autoimmune disorders, providing insights into the modulation of immune responses through JAK1 inhibition. -
JAK Inhibitor
JAK1/TYK2-IN-1 is a potent dual inhibitor targeting Janus kinase 1 (JAK1) and tyrosine kinase 2 (TYK2), with reported IC50 values of 29 nM and 41 nM, respectively. This compound exhibits significant anti-inflammatory and immunomodulatory effects, making it a valuable tool for research related to autoimmune disorders and cytokine signaling pathways. Its ability to selectively inhibit JAK1 and TYK2 enhances its potential for studying the mechanisms of JAK-mediated signaling in various biological contexts. -
JAK Inhibitor
Peficitinib hydrobromide is a selective Janus kinase (JAK) inhibitor, exhibiting IC50 values of 3.9 nM for JAK1, 5.0 nM for JAK2, 0.7 nM for JAK3, and 4.8 nM for Tyk2. This compound is primarily utilized in research related to autoimmune diseases and inflammatory conditions, demonstrating potential therapeutic efficacy in modulating immune responses. Its oral bioavailability makes it a valuable tool for studying JAK signaling pathways in various biological models. -
JAK1/JAK2 Inhibitor
RAI-20 is a potent orally active dual inhibitor of JAK1 and JAK2, demonstrating IC50 values of 15.1 nM and 22.7 nM, respectively. This compound features favorable pharmacokinetic characteristics, including enhanced plasma stability and extended systemic exposure. In preclinical studies using a collagen-induced arthritis rat model, RAI-20 exhibited significant anti-inflammatory and anti-arthritic effects, effectively decreasing paw swelling volume and overall arthritis index. RAI-20 serves as a valuable tool for investigating the mechanisms underlying rheumatoid arthritis pathology. -
JAK3 Inhibitor
Ritlecitinib (malonate) is a selective, orally bioavailable, irreversible inhibitor of JAK3, exhibiting an IC50 of 33 nM. This compound effectively inactivates JAK3, thereby disrupting signaling pathways and downstream STAT phosphorylation triggered by common gamma chain cytokines, including IL-2 and IL-15. Ritlecitinib (malonate) is particularly useful for research into immune-related conditions, as it diminishes Th1/Th17 cell differentiation and function, and has shown efficacy in preclinical models of alopecia areata, adjuvant-induced arthritis, and experimental autoimmune encephalomyelitis. -
JAK Inhibitor
NVP-BSK805 trihydrochloride is an ATP-competitive inhibitor of Janus kinase 2 (JAK2), exhibiting IC50 values of 0.48 nM for JAK2 JH1, 31.63 nM for JAK1 JH1, 18.68 nM for JAK3 JH1, and 10.76 nM for TYK2 JH1. This compound is valuable for studying the roles of JAK family kinases in various biological processes and diseases, including inflammation, hematopoiesis, and cancer. Research applications include preclinical evaluation of therapeutic strategies targeting JAK signaling pathways. -
JAK Inhibitor
Fosifidancitinib is a potent and selective inhibitor of Janus kinase (JAK) 1 and JAK 3. This compound demonstrates significant biological activity by modulating cytokine signaling pathways, making it valuable in research related to allergies, asthma, and autoimmune diseases. Its specificity for JAK kinases supports detailed investigations into JAK-mediated mechanisms and therapeutic strategies. -
JAK Inhibitor
Nezulcitinib is a pan-Janus kinase (JAK) inhibitor with a targeted delivery system for lung tissues. This compound exhibits significant biological activity in modulating inflammatory pathways, making it a valuable tool for research on COVID-19-associated acute lung injury and impaired oxygenation. Its selective action offers potential insights into therapeutic strategies for respiratory conditions linked to JAK activation. -
JAK Inhibitor
LNK01004 is a potent JAK inhibitor, displaying strong inhibitory activity against JAK1 (IC50: 10 nM), JAK2 (IC50: <0.51 nM), and TYK2 (IC50: 1.0 nM). This compound effectively suppresses multiple cytokine-induced p-STAT signaling pathways, making it a valuable tool for the investigation of diseases, particularly atopic dermatitis. Its selective inhibition profile provides insights into therapeutic strategies targeting JAK-mediated pathways. -
JAK2/FLT3 Inhibitor
Pacritinib hydrochloride is a selective inhibitor targeting JAK2 and FLT3, demonstrating inhibitory potency against wild-type JAK2 (IC50=23 nM), the JAK2V617F mutant (IC50=19 nM), and FLT3 (IC50=22 nM) as well as the FLT3D835Y mutant (IC50=6 nM). This compound is primarily utilized in research related to acute myeloid leukemia (AML) and myelofibrosis (MF), making it a valuable tool for studying these hematological malignancies and the associated signaling pathways. -
SYK/JAK Inhibitor
Gusacitinib hydrochloride is a potent dual inhibitor of SYK and JAK kinases, demonstrating IC50 values of 5 nM, 46 nM, 4 nM, 11 nM, and 8 nM for SYK, JAK1, JAK2, JAK3, and TYK2, respectively. This compound effectively suppresses critical inflammatory pathways linked to the pathogenesis of atopic dermatitis. Gusacitinib hydrochloride is suitable for research applications involving chronic hand eczema and various cancers, including basal cell carcinoma. -
JAK-3 Inhibitor
WYE-151650 is a selective inhibitor of Janus kinase 3 (JAK-3), targeting key signaling in immune response. This compound effectively suppresses interleukin-2 (IL-2)-induced phosphorylation of signal transducer and activator of transcription 5 (STAT-5), resulting in decreased cell proliferation associated with JAK-3 activity. WYE-151650 demonstrates potential for research applications in autoimmune diseases and related immunological studies. -
JAK3 Inhibitor
EP009 is a selective inhibitor of JAK3, primarily targeting IL-2-mediated JAK3 tyrosine phosphorylation with an IC50 of 10-20 μM in Kit225 cells. This compound does not influence IL-3-induced JAK2 phosphorylation at concentrations up to 50 μM in BaF/3 cells. Notably, EP009 exhibits significant cytotoxicity in Kit225 cells, reducing cell viability with an LD50 of 5.0 μM, while leaving BaF/3 cells unaffected. This specificity makes EP009 a valuable reagent for research applications involving JAK3 signaling pathways. -
JAK3/BTK Inhibitor
JAK3/BTK-IN-3 is a selective inhibitor of Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK). Targeting both JAK3 and BTK can provide synergistic effects beneficial for the therapeutic intervention of autoimmune diseases. This compound is suitable for research applications focused on elucidating the roles of JAK3 and BTK in various disease mechanisms, facilitating the development of novel treatment strategies. -
JAK Inhibitor
JAK-IN-28 is a potent JAK inhibitor that selectively targets Janus kinases, which are critical mediators of cytokine signaling pathways. This compound exhibits significant anti-inflammatory properties and is valuable for research in cancer and various inflammatory diseases. Its effectiveness in modulating JAK-mediated signaling makes it an essential tool for studying therapeutic strategies in related pathological conditions. -
JAK2/FLT3 Inhibitor
SB1578 is a selective inhibitor of JAK2 and FLT3, exhibiting IC50 values of 46 nM and 60 nM, respectively. This compound demonstrates high selectivity for other kinase targets, making it a valuable tool for research. SB1578 is particularly useful in studying non-oncological indications, such as rheumatoid arthritis, offering insights into potential therapeutic applications in inflammatory diseases. -
JAK Inhibitor
CP-352664 is a selective Janus kinase (JAK) inhibitor that specifically targets JAK3 with an EC50 value of 210 nM. This compound exhibits significant potential in research related to organ transplant rejection and autoimmune disorders, including rheumatoid arthritis. It serves as an important tool for investigating the therapeutic modulation of immune responses in various pathological conditions. -
JAK3/BTK Inhibitor
JAK3/BTK-IN-7 is a potent inhibitor targeting Janus kinase 3 (JAK3) and Bruton’s tyrosine kinase (BTK), demonstrating IC50 values of 2 nM and 14 nM, respectively. This compound exhibits significant anti-inflammatory activity, making it a valuable tool for investigating the underlying mechanisms of rheumatoid arthritis. Its efficacy in modulating inflammatory pathways highlights its potential in related therapeutic research applications. -
JAK2/3 Inhibitor
JAK-2/3-IN-1 is a highly selective inhibitor of Janus kinase 2 (JAK-2) and Janus kinase 3 (JAK-3), exhibiting Ki values of less than 250 nM for both isoforms. This compound is relevant for research applications focused on inflammatory diseases and hematological malignancies where JAK signaling plays a crucial role. Its potency and specificity make it suitable for studying the molecular mechanisms of JAK-related pathways and evaluating potential therapeutic strategies. -
JAK3 Inhibitor
JAK3-IN-16 is a covalent inhibitor of Janus kinase 3 (JAK3), targeting the enzymatic activity that regulates cytokine signaling pathways. This compound exhibits potent inhibition of JAK3, making it a valuable tool for research into immune response modulation and related therapeutic applications. JAK3-IN-16 is particularly useful in studies focused on autoimmune diseases and hematological disorders. -
JAK Inhibitor
MMT3-72-M2 is a selective inhibitor targeting Janus kinase 1 (JAK1). This compound exhibits potent inhibition of JAK1 with an IC50 value of 10.8 nM, and also inhibits JAK2, TYK2, and JAK3 with IC50 values of 26.3 nM, 91.6 nM, and 328.7 nM, respectively. MMT3-72-M2 is valuable for research in signaling pathways related to immune responses and inflammation. -
JAK Inhibitor
Peficitinib hydrochloride is a selective Janus kinase (JAK) inhibitor that effectively targets JAK1, JAK2, JAK3, and Tyk2, with IC50 values of 3.9 nM, 5.0 nM, 0.7 nM, and 4.8 nM, respectively. This compound is primarily used in research to investigate JAK-dependent signaling pathways and for studies related to inflammatory and autoimmune diseases. Its potent inhibitory activity makes it a valuable tool for exploring therapeutic options against conditions such as rheumatoid arthritis and psoriasis. -
JAK3/JAK1/TBK1 Inhibitor
CS12192 is a JAK3/JAK1/TBK1 inhibitor that modulates immune responses by inhibiting key signaling pathways involved in inflammatory processes. This compound has demonstrated efficacy in improving survival and promoting weight gain. CS12192 holds potential for research applications in graft-versus-host disease (GVHD), offering insights into therapeutic strategies for managing this condition. -
JAK2 Inhibitor
JAK2-IN-15 is a potent and selective inhibitor of JAK2, exhibiting an IC50 value of 1.17 nM. It effectively targets the JAK2-STAT signaling pathway, making it a valuable tool for investigating therapeutic strategies. In preclinical studies, JAK2-IN-15 has demonstrated significant improvements in hematocrit levels and reductions in splenomegaly in an Epoetin beta-induced mouse model. This compound is particularly relevant for research into Polycythemia Vera (PV) and related hematological disorders. -
IKKβ/JAK2 Inhibitor
EC-70124 is an orally active multikinase inhibitor that targets IKKβ and JAK2. By blocking IkB phosphorylation and the activation of STAT3 (Tyr705), EC-70124 inhibits NF-κB nuclear translocation and impedes STAT3 transcriptional activity. This compound has demonstrated the ability to reduce tumor growth and diminish cancer stem cell populations in prostate cancer cells and xenograft models, making it a valuable tool for research in prostate cancer. -
JAK Inhibitor
JAK-IN-30 is a potent and water-soluble inhibitor of Janus kinases (JAKs), exhibiting IC50 values of 2 nM for JAK2, 15 nM for JAK1, 18 nM for JAK3, and 2 nM for TYK2. This compound demonstrates significant biological activity in modulating JAK signaling pathways, making it a valuable tool for investigating inflammatory conditions. Its applicability in research extends to the study of dry eye disease (DED) and other JAK-related disorders.
