Catalog No.
Product Name
Application
Product Information
Citations
-
ACAT Inhibitor
Terpendole I is a fungal indoloditerpene that functions as an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, exhibiting an IC50 value of 145 µM. This compound demonstrates significant biological activity in modulating cholesterol metabolism, making it a valuable tool for studying lipid regulation and related metabolic disorders. Terpendole I can be utilized in research focused on atherogenesis, cholesterol homeostasis, and the therapeutic exploration of cardiovascular diseases. -
Acyltransferase Inhibitor
Amidepsine D is an acyltransferase inhibitor derived from the fungal metabolite isolated from the culture broth of Humicola sp. FO-2942. It specifically inhibits diacylglycerol acyltransferases (DGAT), playing a crucial role in lipid metabolism regulation. This compound is valuable for research applications focused on examining lipid biosynthesis pathways and exploring potential therapeutic targets in metabolic disorders. -
ACAT Inhibitor
Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), derived from the mycelial cake of Gibberella lateritium IFO 7188. This compound exhibits significant biological activity by inhibiting the growth of various human cancer cell lines, as well as displaying antibacterial effects against gram-positive bacteria and antifungal activity against Candida albicans. Lateritin is a valuable tool for research in cancer therapeutics and the study of lipid metabolism. -
ACAT Inhibitor
Glisoprenin A is an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), targeting cholesterol metabolism. It has demonstrated significant activity in inhibiting the formation of appressorium on hydrophobic surfaces in the fungal pathogen Magnaporthe grisea. This compound is valuable for research into fungal plant pathogens and cholesterol metabolism dynamics. -
ACAT Inhibitor
Glisoprenin D is an ACAT inhibitor that selectively targets cholesterol acyltransferase, thereby influencing lipid metabolism. It has been shown to inhibit the formation of appressorium on the hydrophobic surfaces of Magnaporthe grisea, making it a valuable tool for studying fungal pathogenesis and plant-fungal interactions. This compound has potential applications in both basic and applied research within mycology and plant sciences. -
ACAT Inhibitor
Glisoprenin C is a selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), which plays a crucial role in cholesterol metabolism. By inhibiting ACAT, Glisoprenin C effectively disrupts cholesterol esterification, impacting the pathogenicity of organisms such as Magnaporthe grisea by preventing appressorium formation on hydrophobic surfaces. This compound is valuable in studying cholesterol-related pathways and evaluating potential therapeutic strategies against fungal pathogens. -
ACAT Inhibitor
Glisoprenin E is an ACAT inhibitor that effectively inhibits cholesterol acyltransferase activity. This compound has demonstrated biological activity by preventing the formation of appressorium on hydrophobic surfaces in the phytopathogen Magnaporthe grisea. Its applications are significant in studying fungal pathogenicity and the role of lipid metabolism in plant-fungal interactions. -
Antifungal Agent
Dapaconazole is an antifungal agent that primarily inhibits the activity of sterol 14α-demethylase cytochrome P450, exhibiting an IC50 of 1.4 μM. This inhibition disrupts the synthesis of ergosterol, a critical component of fungal cell membranes, thereby exerting antifungal effects. Dapaconazole is applicable in research focused on fungal infections and the development of novel antifungal therapies. -
Antifungal Agent
VT-1598 tosylate is an orally active antifungal agent that selectively inhibits CYP51, demonstrating effective antifungal properties against Candida auris. Additionally, VT-1598 tosylate serves as a click chemistry reagent, incorporating an alkyne group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. This dual functionality positions VT-1598 tosylate as a valuable tool in both antifungal research and synthetic chemistry applications. -
CYP51 Inhibitor
CYP51-IN-21 is a potent inhibitor of cytochrome P450 51 (CYP51), demonstrating significant antifungal activity against various pathogenic fungi, including drug-resistant strains. By targeting CYP51, CYP51-IN-21 disrupts the biosynthesis of essential sterols, impairing fungal growth and viability. Additionally, CYP51-IN-21 effectively inhibits the formation of fungal biofilms, making it a valuable candidate for research in antifungal therapeutics and biofilm-related studies. -
Fungal Terpenoid
Terretonin is a fungal terpenoid derived from Aspergillus terreus, primarily targeting enzymatic pathways involved in its biosynthesis. Its production involves a complex sequence of reactions, including oxidation by cytochrome P450 Trt6, isomerization by Trt14, and final processing by the non-heme iron-dependent dioxygenase Trt7. This compound exhibits significant biological activity with potential applications in pharmaceutical research, particularly as a lead for developing novel antifungal agents. -
Anti-bacterial Agent
6-Bromocoumarin is a potential anti-bacterial agent that demonstrates selective binding affinity for α and β estrogen receptors. While it does not inhibit 17β-HSD1, its unique properties make it a valuable compound for researchers studying bacterial resistance mechanisms and the role of estrogen receptors in microbial pathogenesis. 6-Bromocoumarin may provide insights into the development of novel anti-bacterial therapies targeting hormonal pathways. -
Acyltransferase Inhibitor
Amidepsine A is an acyltransferase inhibitor derived from the fungal metabolite of Humicola sp. FO-2942. This compound specifically inhibits the activity of diacylglycerol acyltransferases (DGAT), which play a crucial role in lipid metabolism. Its biological activity makes Amidepsine A a valuable reagent for research applications focused on lipid biosynthesis and metabolic regulation. -
Fungicide
Cyazofamid is a fungicide that primarily targets the impairment of ATP production in fungal cells. It acts by inhibiting organic cation transporter 3 (OCT3) and organic anion transporter 1 (OAT1), with IC50 values of 1.54 μM and 17.3 μM, respectively. This compound is utilized in research to explore mechanisms of fungicidal activity and to develop effective strategies for managing fungal diseases in agricultural settings. -
Fungicide
Fenaminstrobin is a strobilurin fungicide that targets the cytochrome bc1 complex within the mitochondrial respiratory chain, leading to the inhibition of ATP production. This compound demonstrates significant biological activity in controlling a variety of fungal diseases, including Fusarium ear rot, downy mildew, rice blast, and pear scab. Additionally, Fenaminstrobin exhibits acute toxicity to the aquatic organism Daphnia magna, making it relevant for ecological impact studies. Its application in agricultural research focuses on crop protection and disease management in various plant systems. -
Mitochondrial Inhibitor
Fusaramin is a mitochondrial inhibitor that demonstrates potent activity against plant pathogenic fungi. It disrupts mitochondrial function, leading to the impairment of fungal growth and viability. This compound is valuable for research applications focused on plant disease management and the study of mitochondrial biology in pathogenic organisms. -
SDH Inhibitor
Inpyrfluxam is a potent inhibitor of succinate dehydrogenase (SDH), specifically targeting the ubiquinone binding pocket of the mitochondrial SDH complex subunits ViSDHB, ViSDHC, and ViSDHD. This inhibition disrupts cellular respiration, demonstrating efficacy in inhibiting conidial germination and mycelial growth of Venturia inaequalis in vitro. Inpyrfluxam is valuable for research studies focused on apple scab and related fungal pathogens. -
HIV-1 Integrase Inhibitor
GSK-1264 is an HIV-1 integrase inhibitor that targets the catalytic core and C-terminal domains of the HIV-1 integrase enzyme. By promoting the formation of an open polymer structure of integrase dimers, GSK-1264 disrupts the late stages of HIV replication and interferes with viral particle assembly. This compound is valuable for research focused on HIV infection and understanding integrase-mediated processes in the viral life cycle. -
HIV-1 Integrase Inhibitor
HIV-1 Integrase Inhibitor 8 is a selective inhibitor targeting the HIV-1 integrase enzyme. It demonstrates potent activity against viral replication by disrupting the integration of viral DNA into the host genome, which is essential for the HIV life cycle. This compound is primarily utilized in research focused on antiretroviral therapy and the development of HIV treatments, contributing to the understanding of integrase inhibition mechanisms. -
HIV-1Integrase Inhibitor
GSK3839919A is a potent allosteric inhibitor of HIV-1 integrase, targeting the enzyme responsible for the integration of viral DNA into the host genome. This compound exhibits significant antiviral activity against HIV-1, making it a valuable tool for research applications focused on the development of novel antiretroviral therapies and the study of HIV replication mechanisms. Its unique mechanism of action may provide insights into resistance pathways and inform drug design strategies. -
HIV Integrase Inhibitor
His-Cys-Lys-Phe-Trp-Trp is an HIV integrase inhibitor, exhibiting an IC50 of 2 μM. This compound impedes the integrase enzyme's function, thereby preventing viral DNA integration into the host genome. His-Cys-Lys-Phe-Trp-Trp is valuable for research focused on HIV pathogenesis and the development of antiretroviral therapies. -
HIV-1 integrase Inhibitor
(S)-BI-1001 is a potent HIV-1 integrase inhibitor, demonstrating significant antiviral activity. It exhibits an IC50 value of 28 nM, an EC50 of 450 nM, and a Kd of 4.7 μM, indicating its efficacy in disrupting viral replication processes. This compound is valuable for research applications focused on HIV-1 pathogenesis and therapeutic development. -
HIV-1 Integrase Inhibitor
HIV-1 Integrase Inhibitor 7 is a potent inhibitor of HIV-1 integrase, exhibiting an IC50 value of 33.3 nM. This compound effectively interferes with the integration of viral DNA into the host genome, making it essential for studies focused on HIV-1 replication and treatment strategies. It serves as a valuable tool in research applications aimed at understanding HIV-1 biology and developing therapeutic interventions against HIV. -
HIV-1 Integrase Inhibitor
HIV-1 Integrase Inhibitor 11 is a potent inhibitor of HIV-1 integrase, demonstrating an IC50 of 125 μM. This compound effectively disrupts the integration of viral DNA into the host genome, thereby hindering the replication process of HIV-1. It is suitable for research applications aimed at developing antiretroviral therapies and studying the mechanisms of HIV integration and resistance. -
HIV-1 IN/RT RNase H Inhibitor
2-Hydroxyisoquinoline-1,3(2H,4H)-dione is an inhibitor of HIV-1 integrase (IN) and reverse transcriptase (RT) ribonuclease H (RNase H), demonstrating IC50 values of 6.32 µM and 5.9 µM, respectively. This compound serves as a valuable tool for studying HIV-1 replication and provides insights into the inhibition mechanisms of viral enzymes. Its biological activity and specificity make it useful for research applications focused on antiviral drug development and understanding HIV-1 pathogenesis. -
HIV Integrase Inhibitor
L-870812 is an HIV integrase inhibitor that targets the strand transfer mechanism of HIV-1 integration. This compound effectively blocks both cell-free and cell-associated HIV-1 infections, demonstrating activity against subtype C and CRFO2_AG primary isolates. L-870812 is suitable for research applications involving replication-deficient HIV-1 Ba-L (env) pseudovirus, facilitating studies aimed at understanding HIV biology and developing therapeutic strategies. -
α-glucosidase Inhibitor
CM-10-18 is a potent inhibitor of α-glucosidases I and II, demonstrating significant activity in vitro and in animal models. This compound also exhibits antiviral properties by inhibiting dengue virus (DENV) infection in cultured human cells, while effectively reducing peak viremia in mice. CM-10-18 is valuable for research applications related to glycosidase inhibition and viral pathogenesis. -
Anti-Viral Agent
IHVR-17028 is a broad-spectrum antiviral agent that primarily targets endoplasmic reticulum α-glucosidase I. It demonstrates significant antiviral activity against various viruses, including Bovine viral diarrhea virus (BVDV), Tick-borne choriomeningitis virus (TCRV), and Dengue virus (DENV), with EC50 values of 0.4 μM, 0.26 μM, and 0.3 μM, respectively. With an IC50 of 0.24 μM, it effectively inhibits ER α-glucosidase I, making it a valuable tool for research into infectious diseases. -
Fungal Phytotoxin
Radicinin is a fungal phytotoxin that functions as a target-specific bioherbicide, effectively inhibiting the growth of invasive Buffelgrass (Cenchrus ciliaris). This compound exhibits significant biological activity by disrupting the metabolic processes of the plant, making it a valuable tool for managing invasive species. It is primarily applied in research focused on ecological restoration and integrated weed management strategies. -
Mycotoxin Metabolite
Asticolorin C is a mycotoxin metabolite derived from the fungus Aspergillus multicolor. It exhibits biological activity by potentially influencing cellular processes related to mycotoxin detoxification and metabolism. This compound serves as a valuable tool in research applications focusing on mycotoxin biology, fungal ecology, and the assessment of mycotoxin contamination in food and agricultural products. -
Mycotoxin Metabolite
Asticolorin A is a mycotoxin metabolite derived from Aspergillus multicolor. It exhibits biological activity related to fungal metabolism and can be utilized in research exploring mycotoxin effects and toxicology. This compound may serve as a valuable tool for studying the biochemical pathways involved in mycotoxin metabolism and the impact of fungal metabolites on health. -
Antibiotic
Cefonicid monosodium is a long-acting cephalosporin antibiotic that primarily targets bacterial cell wall synthesis. It possesses broad-spectrum antimicrobial activity, effectively combating a range of Gram-positive and Gram-negative bacteria. Additionally, Cefonicid acts as a noncompetitive inhibitor of class I β-lactamase, with a Ki value of 0.8 μM, making it a valuable reagent for research on bacterial infections and antibiotic resistance. -
Bacterial Glycoside Hydrolase Activator
4-Ethoxyquinazoline is a selective activator of bacterial glycoside hydrolases, demonstrating an AC50 of 3.5 mM. This compound enhances the enzymatic activity of glycoside hydrolases, supporting research focused on bacterial metabolism and cell wall remodeling. Its role in modulating enzyme activity makes it a valuable tool for studies on bacterial physiology and potential therapeutic applications. -
Bacterial Metabolite
Corynecin V is a chloramphenicol-like bacterial metabolite that targets bacterial protein synthesis. It exhibits antibacterial activity against a range of gram-positive bacteria by inhibiting peptidyl transferase activity in the ribosome. This compound is of significant interest in microbiological research and antibiotic development, providing insights into novel therapeutic strategies against antibiotic-resistant strains. -
Drug Derivative
Fluopicolide is a novel drug derivative with a primary mechanism targeting specific protein interactions. It exhibits significant antifungal activity, making it suitable for studying plant pathogen resistance and developing effective agricultural fungicides. Fluopicolide is particularly valuable for research applications focused on crop protection and plant disease management strategies. -
Alternaria Metabolite
4-Hydroxyalternariol is a metabolite derived from the fungus Alternaria. It exhibits significant cytotoxic activity and serves as a potent inhibitor of various cell proliferation pathways. This compound is valuable in research focused on mycotoxin studies, apoptosis, and cancer biology, facilitating investigations into the biological effects of fungal metabolites on human health. -
Metabolite
(Z)-2-Octenoic acid is the Z-isomer of 2-Octenoic acid, a significant metabolite derived from Mucor species. It plays a role in various biochemical pathways and can be utilized in studies exploring fungal metabolism and organic compound synthesis. This compound may aid in the investigation of microbial interactions and the functional roles of metabolites in ecological systems. -
Secondary Metabolite
4-Hydroxyscytalone is a microbial secondary metabolite isolated from the oak fungus Diplodia corticola. This compound exhibits toxicity toward Artemia salina with an LC50 value of 90.6 μg/mL, indicating its potential as a bioactive agent. While it does not demonstrate significant antifungal activity, 4-Hydroxyscytalone may serve as a valuable tool in cancer therapy research, facilitating investigations into novel treatment strategies. -
Squalene Synthase Inhibitor
Squalestatin 3 is a potent squalene synthase inhibitor, demonstrating an IC50 of 6 nM. This secondary metabolite, isolated from the fungus Phoma, plays a critical role in regulating the biosynthesis of sterols and terpenes. It is valuable for research applications focused on cholesterol biosynthesis, antifungal research, and the exploration of lipid metabolism pathways. -
Fungal Lactone
Pestalotin is a fungal lactone and a secondary metabolite derived from the endophytic fungus Pestalotiopsis microspora. This compound exhibits significant antifungal activity, making it a valuable tool for research in mycology and natural product chemistry. Its bioactive properties may facilitate the exploration of new antimicrobial agents and contribute to the study of plant-fungal interactions. -
Secondary Metabolite
Fumiquinazoline D is a secondary metabolite that acts as a mycotoxin. It exhibits significant biological activity by inhibiting various cellular processes, potentially impacting cell viability and proliferation. Fumiquinazoline D is utilized in research to study the effects of mycotoxins on human health and to explore its mechanisms of action in fungal biology and toxicity. -
Anticancer Agent/SV40 Promoter Activator
TMC-205 is a natural fungal metabolite that acts as an SV40 promoter activator. It exhibits significant antiproliferative activity against various cancer cell lines, making it a valuable tool for cancer research. This compound is useful for studies on transcriptional regulation and the mechanisms of oncogenesis. -
Antibiotic
Neohydroxyaspergillic acid is an antibiotic that exhibits activity against specific bacteriophages. This compound can be utilized in research focusing on antibacterial mechanisms and the interaction between antibiotics and bacteriophages. Its potential applications extend to studying resistance and susceptibility patterns in microbial populations. -
Bacterial Metabolite
Corynecin IV is a chloramphenicol-like bacterial metabolite that targets bacterial protein synthesis through inhibition of the bacterial ribosome. This compound exhibits antimicrobial activity against a range of Gram-positive bacteria, making it valuable for research in antibiotic development and resistance studies. Additionally, Corynecin IV can be utilized to explore mechanisms of action for similar anti-infective agents. -
Fungi Metabolites
Scytalone is a naphthalenone pentaketide that serves as a natural precursor to melanin. This compound is derived from certain tracheiphilous fungi and is relevant in the study of fungal metabolites. Research indicates that scytalone may play a role in grape esca disease, making it a valuable reagent for investigations into plant pathology and fungal biology. -
Ciosynthetic Precursor of Satratoxin G
Roridin L2 is a fungal metabolite that serves as a biosynthetic precursor to Satratoxin G. This compound plays a crucial role in the synthesis of Satratoxin G, which is known for its potential biological activities. Despite its significance in research applications, Roridin L2 exhibits minimal toxic activity both in vitro and in vivo, making it a valuable reagent for studying fungal metabolites and their derivatives. -
Bacterial Metabolite
4-Hydroxycinnamide is a bacterial metabolite derived from Streptomyces sp. PU-KB10-4. This compound exhibits significant biological activity, making it a valuable tool in microbial research. Its role in bacterial metabolism may provide insights into host-microbe interactions and potential therapeutic applications. -
Metabolite
Eremofortin A is a natural metabolite derived from the fungus Penicillium roqueforti. This compound exhibits a range of biological activities, including potential antifungal and cytotoxic effects. Eremofortin A is primarily utilized in research applications focused on exploring fungal metabolites and their therapeutic potentials in the treatment of various diseases. -
Acinar Morphogenesis Inhibitor
Fusarisetin A is a pentacyclic fungal metabolite that functions as an acinar morphogenesis inhibitor. This compound disrupts the normal formation and development of acinar structures in cells, making it a valuable tool for investigating the mechanisms of acinar morphogenesis. Its unique biological activity supports research in developmental biology and tissue engineering. -
C-14 Epimer
14-epi-Berkeleylactone F is a C-14 epimer of Berkeleylactone F, isolated from the fungus Penicillium turbatum NRRL 5630. While it demonstrates structural similarity to its counterpart, 14-epi-Berkeleylactone F exhibits no significant biological activity against a range of pathogens, including Staphylococcus aureus, Bacillus subtilis, E. coli, Candida albicans, and the parasite Giardia duodenalis, as well as NS-1 murine myeloma cells. This compound may be relevant for studies focusing on epimerization and structural analysis in fungal metabolites.
