Catalog No.
Product Name
Application
Product Information
Citations
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Siderophore
Nannochelin B is a citrate-hydroxamate siderophore that targets iron acquisition pathways in microbial organisms. It demonstrates significant growth-inhibitory activity against various bacterial and fungal species. This compound is useful for research applications in studying microbial iron metabolism and developing antifungal or antibacterial strategies. -
Antifungal Agent
Antifungal agent 24 is a potent antifungal compound that targets Candida albicans, exhibiting a minimum inhibitory concentration (MIC) of 0.03 μg/mL. This compound is ideal for research applications focusing on fungal infections, particularly in the context of developing therapeutic strategies against Candida species. Its high efficacy makes it a valuable tool for studying antifungal mechanisms and resistance. -
Antimicrobial Inhibitor
Antibacterial Agent 101 (Compd 7f) is an antimicrobial inhibitor targeting both bacterial and fungal pathogens. With minimum inhibitory concentration (MIC) values ranging from 4 to 32 µg/mL, it demonstrates potent antibacterial and antifungal activity. This compound is suitable for research applications focused on developing new antimicrobial therapies. -
Antifungal Metabolite
Canadensolide is an antifungal metabolite derived from Penicillium canadense. It exhibits potent antifungal activity against various pathogenic fungi, making it valuable for studying fungal infections and developing antifungal strategies. Research applications include investigating mechanisms of action in fungal resistance and exploring potential therapeutic uses in clinical settings. -
Chitin Deacetylase Inhibitor
CDA-IN-1 is a potent inhibitor of chitin deacetylase (CDA), demonstrating significant antifungal activity. This compound effectively suppresses fungal growth by inhibiting fungal CDA activity, stimulating the plant immune response, and promoting the accumulation of reactive oxygen species (ROS). At a concentration of 100 μM, CDA-IN-1 achieves inhibition rates of 86.9% and 74.5% against the chitin deacetylases PxCDA1 and PxCDA2 of Pseudoperonospora xanthii, respectively. CDA-IN-1 is a valuable tool for research into plant fungal disease control, particularly in studies focused on diseases such as cucurbit powdery mildew and tomato gray mold. -
Antibiotic
IT-143A is an antibiotic that demonstrates significant antibacterial and antifungal activity, specifically targeting Micrococcus luteus and Aspergillus fumigatus with a minimum inhibitory concentration (MIC) ranging from 6.25 to 25 μg/mL. Additionally, IT-143A effectively inhibits the proliferation of KB cancer cells with an IC50 of 0.36 ng/mL. This compound is valuable for research applications focusing on microbial resistance and oncology studies. -
Antifungal Agent
Deoxyfusapyrone is an antifungal alpha-pyrone derived from Fusarium semitectum, targeting fungal pathogens. It exhibits significant antibacterial activity against Geotrichum candidum as demonstrated in disk diffusion assays. Additionally, Deoxyfusapyrone is non-toxic to Artemia salina larvae, making it a promising candidate for further research in antifungal applications. -
Fungal Inhibitor
Oxadixyl is a fungicide that targets fungal growth by inhibiting key cellular processes. It demonstrates significant biological activity in the presence of fungi, making it useful for evaluating its effects on microbial populations during processes such as malic fermentation in winemaking. This compound is valuable for researchers investigating antifungal treatments and their implications in fermentation science. -
Macrolide Antibiotic
PC-766B is a macrolide antibiotic that exhibits significant activity against Gram-positive bacteria, as well as certain fungi and yeasts, while showing no effectiveness against Gram-negative bacteria. Additionally, PC-766B demonstrates antitumor activity against murine tumor cells, making it a candidate for cancer research applications. It also displays weak inhibitory activity against Na+, K+-ATPase, providing insights into its potential biochemical interactions. -
Antifungal Agent
2-Decanone is an antifungal agent that targets fungal pathogenesis. It effectively inhibits mycelial growth, spore germination, and appressorium formation by downregulating key genes such as MfBmp1 and MfPls1. The compound induces the accumulation of reactive oxygen species (ROS), leading to mitochondrial damage and subsequent spore apoptosis. Its efficacy makes 2-Decanone a valuable candidate for research in postharvest disease control in fruits and vegetables. -
Fungal
Bassianin is a fungal compound recognized for its ability to inhibit erythrocyte membrane ATPase, leading to cell lysis. The compound's mechanism of action involves disrupting membrane integrity, which contributes to its biological effects. Bassianin is primarily utilized in research applications focused on investigating membrane dynamics and cellular integrity, particularly in studies related to parasitology and fungal biology. -
Anti-fungal Agent
Tylophorinicine is a phenanthroindolizidine alkaloid that acts primarily as an anti-fungal agent by inhibiting thymidylate synthase. It demonstrates minimum inhibitory concentrations (MIC) ranging from 2-4 mg/mL against TdnH and 0.6-2.5 mg/mL against TnnH for various Candida species. This compound is derived from Tylophora asthamatica and Pergularia pallida, positioning it as a valuable tool for researching antifungal mechanisms and therapeutic applications in fungal infections. -
Antibacterial Agent
PK-10 is a synergistic antibacterial agent that combines the active components of Fluconazole, exhibiting potent antifungal activity against various strains of Fluconazole-resistant Candida albicans. This compound effectively inhibits hyphae formation and induces the accumulation of reactive oxygen species, leading to mitochondrial dysfunction. Additionally, PK-10 disrupts mitochondrial membrane potential and decreases intracellular ATP levels, highlighting its potential applications in antifungal research and therapeutic development. -
Antibacterial/Antifungal Agent
Antibacterial Agent 100 (Compound 7c) is an antibacterial and antifungal reagent targeting a range of microbial pathogens. It exhibits significant biological activity with minimum inhibitory concentration (MIC) values of 4 μg/mL against Staphylococcus aureus, 4 μg/mL against Candida albicans, and 8 μg/mL against Cryptococcus neoformans. This compound is suitable for research applications focused on the inhibition of bacterial and fungal growth, making it a valuable tool in microbiological studies. -
Antifungal Agent
AS-2077715 is an antifungal agent that exhibits inhibitory activity against Trichophyton species. Isolated from the fermentation broth of Capnodium sp. 339855, this compound serves as a valuable tool for investigating fungal infections and their mechanisms. Its efficacy makes it suitable for research applications focused on antifungal drug development and the study of dermatophyte-related diseases. -
Antibiotic
Leucinostatin D is a peptide antibiotic derived from the fungus Paecilomyces marquandii. It exhibits potent antibacterial activity against Gram-positive bacteria and antifungal effects against select fungal species. This compound is valuable for studying microbial resistance mechanisms and evaluating its potential as a therapeutic agent in treating bacterial and fungal infections. -
Fungal
Antibacterial agent 67 is a potent inhibitor of succinate dehydrogenase, exhibiting an IC50 of 0.03 μM, significantly outperforming fluxapyroxad, which has an IC50 of 4.40 μM. This compound demonstrates strong antifungal activity, making it a valuable tool in research aimed at understanding fungal metabolism and developing antifungal therapies. Its high specificity and efficacy position it as a promising candidate for further study in antifungal drug discovery. -
Antifungal Limonoid
1-Deacetylnimbolinin B is a nimbolinin-type limonoid with significant antifungal activity, derived from the fruits of Melia toosendan. This compound demonstrates a broad spectrum of biological activities, including insecticidal, nematicidal, and cytotoxic effects. It is of particular interest for researchers studying natural antifungal agents and exploring the potential applications of limonoids in agricultural and medicinal contexts. -
CYP51 Inhibitor
CYP51-IN-19 is a potent inhibitor of cytochrome P450 51 (CYP51), a critical enzyme involved in sterol biosynthesis in fungi. This compound induces the generation of reactive oxygen species (ROS), leading to significant fungicidal activity. It is primarily utilized in antifungal research and the development of therapeutic agents targeting fungal infections. -
Antifungal Antibiotic
UK-2A is a potent antifungal antibiotic that targets fungal organisms through the inhibition of cell wall synthesis. Its ability to disrupt the integrity of the fungal cell wall leads to cell lysis and death, making it an effective agent in combating fungal infections. UK-2A is particularly useful in research applications focused on antifungal drug development and the mechanistic study of fungal resistance. -
Antifungal Agent
Antifungal Agent 26 is a derivative of Pradimicin A that exhibits potent antifungal, antiviral, and antiparasitic activity. Its primary mechanism involves binding to d-mannose (Man)-containing glycans present on pathogenic species. This compound serves as a valuable tool for research into fungal, viral, and parasitic infections, facilitating the study of novel therapeutic approaches in these areas. -
Fungicide
Zoxamide is an oomycete fungicide that targets the disruption of nuclear division in fungal pathogens. Its primary mechanism involves the destabilization of the microtubule cytoskeleton in Phytophthora capsici germlings, leading to impaired growth and development. Zoxamide is utilized in agricultural research to study the mechanisms of fungicide action and to develop effective management strategies against oomycete diseases. -
Fungal Inhibitor
Antifungal agent 59 is a potent fungal inhibitor with minimum inhibitory concentration (MIC) values ranging from 0.01 to 1 μg/mL. This compound effectively disrupts the formation of fungal biofilms, making it a valuable tool for research in mycology and fungal pathogenesis. Its favorable safety profile further supports its application in studying antifungal mechanisms and therapeutic approaches. -
Anti-fungal Agent
Perinaphthenone functions as an antifungal agent, exhibiting significant activity against various fungal strains. It demonstrates IC50 values of 36.2 μM and 39.0 μM against Botrytis spp. and Botryodiplodia spp. at 60 hours, respectively, as well as a notable IC50 of 13.3 μM against Fusarium spp. at day 3. This compound is primarily utilized in research applications focused on fungal inhibition and plant pathology studies. -
Fungal Inhibitor
Fludazonium chloride is a potent antifungal agent that targets a range of fungal pathogens. It exhibits strong inhibitory activity against both superficial and systemic fungal infections, making it suitable for therapeutic applications in mycoses treatment and prevention. This compound can be utilized in research to further understand antifungal mechanisms and develop new treatments. -
Antifungal Agent
Pradimicin A is a potent antifungal agent that exhibits an MIC of 4 μg/mL against Candida rugosa. In addition to its antifungal properties, Pradimicin A demonstrates antiviral activity against enveloped viruses, including coronavirus and HIV. The compound has unique aggregation properties and can selectively bind to d-mannose in the presence of calcium ions, making it a valuable tool for research in microbial pathogenesis and antiviral mechanisms. -
Echinocandin
Rezafungin is a next-generation echinocandin with a broad-spectrum antifungal activity. It exhibits potent efficacy against various fungal pathogens, including Candida spp., Aspergillus spp., and Pneumocystis spp. This compound is primarily utilized in research applications focused on antifungal resistance, therapeutic efficacy, and the development of new treatment strategies for invasive fungal infections. -
Fungicide Agent
Fluconazole mesylate is a triazole antifungal agent that targets fungal sterol biosynthesis by inhibiting the enzyme lanosterol demethylase. It exhibits significant antifungal activity against a variety of pathogenic fungi, making it effective in the treatment and prevention of both superficial and systemic fungal infections. This compound is widely utilized in clinical research and can aid in the development of antifungal therapies. -
Topical Antimicrobial
Voxvoganan (LTX-109) is a topical antimicrobial agent that targets Staphylococcus aureus with a minimum inhibitory concentration (MIC) range of 2 to 4 μg/mL. It demonstrates potent activity against bacterial skin infections and fungal infections. Additionally, Voxvoganan is applicable in studies involving nasal decolonization of methicillin-resistant Staphylococcus aureus (MRSA). -
Microbial Inhibitor
Antifungal agent 38 is a heterocyclic disulfide that acts as a potent microbial inhibitor. Its primary mechanism involves inducing hyphal shrinkage and disrupting the integrity of the plasma membrane, leading to cellular damage and leakage of intracellular contents. This compound is valuable for research applications focused on antifungal and antibacterial activities, offering insights into cell membrane dynamics and potential therapeutic approaches against microbial infections. -
Antifungal Agent
Antifungal Agent 118 (compound C22) primarily targets hyphal growth in pathogens, specifically inhibiting the development of V. mali. Through the induction of oxidative damage, it effectively disrupts the integrity of the cell membrane, showcasing significant antifungal properties. This compound is valuable for research applications focused on studying fungal pathogenesis and developing antifungal strategies. -
Antifungal Agent/HIV-1 Inhibitor
Amphotericin B methyl ester hydrochloride is a derivative of the polyene antibiotic amphotericin B, functioning primarily as an antifungal agent. This compound exhibits potent antifungal activity by binding to cholesterol in fungal cell membranes, leading to cell death. Additionally, it disrupts HIV-1 particle production and significantly inhibits HIV-1 replication, making it valuable for research in antifungal therapies and HIV treatment studies. -
Antifungal Agent
3,5-Dimethoxybenzoic acid is an aromatic organic acid primarily noted for its antifungal properties. It demonstrates potent antifungal activity against A. rabiei, with a minimum inhibitory concentration (MIC) of 0.125 mg/mL. In addition to its antifungal applications, this compound serves as an important intermediate in the synthesis of anticancer agents. Furthermore, 3,5-Dimethoxybenzoic acid is recognized for its anti-wrinkle, anti-inflammatory, antioxidant, and skin regeneration effects. -
QoI-Type Fungicide
Orysastrobin is a QoI-type fungicide that acts as a quinone outside inhibitor, effectively targeting fungal respiration. It demonstrates potent fungicidal activity against rice diseases such as leaf and panicle blast, as well as sheath blight. This compound is valuable for agricultural research focused on improving crop protection strategies and enhancing yield in rice cultivation. -
Anti-Fungal Agent
NP213 is a first-in-class synthetic antimicrobial peptide that exhibits potent anti-fungal activity. It targets the fungal cytoplasmic membrane, inducing membrane perturbation and disruption, which leads to cell death. NP213 has demonstrated effectiveness in treating nail fungal infections, offering a well-tolerated option for clinical applications in antifungal therapy. -
Antitumor Antibiotic
Oligomycin E is an antitumor antibiotic derived from Streptomyces. It exhibits potent antifungal activity, with minimum inhibitory concentration (MIC) values ranging from 2 to 75 μg/mL. Oligomycin E demonstrates significant cytotoxicity against HeLa cells, exhibiting an IC50 of 0.014 μg/mL, making it valuable for investigations into cancer therapeutics and antifungal mechanisms. -
Antifungal Substance
Pyromeconic acid functions as an antifungal agent, exhibiting significant activity against various fungal pathogens. Its unique mechanism involves disrupting fungal cell wall synthesis, thereby inhibiting growth and proliferation. This compound is utilized in research applications aimed at understanding fungal biology and developing new antifungal therapies. -
Antifungal Antibiotic/Iron Chelator
Dihydroaeruginoic acid functions as an antifungal antibiotic and iron chelator. This thiazoline derivative, synthesized from salicylate and cysteine, effectively chelates Fe(III) and inhibits ribonucleotide reductase, leading to suppressed DNA replication and a G1/S cell cycle block. It demonstrates significant activity against phytopathogenic fungi and bacteria, notably inhibiting the growth of Candida albicans and preventing biofilm formation in Agrobacterium tumefaciens through iron sequestration. Dihydroaeruginoic acid is valuable for research into phytopathogenic infections and leukemia treatment strategies. -
metabolite
4'-Methyl-β-naphthoflavone is a metabolite derived from naphthoflavones, specifically showing activity as a modulator of cytochrome P450 enzymes. Its key biological activity involves the regulation of CYP-450, which is critical for various metabolic processes in fungi. This compound is valuable for research investigating the enzymatic pathways influenced by naphthoflavones and their implications in fungal biology. -
Antitumor Agent
Kievitone is an isoflavanone that demonstrates significant antitumor activity. Isolated from the hypocotyls of Phaseolus vulgaris L. infected by Rhizoctonia solani Kühn, Kievitone also exhibits antifungal properties. This compound serves as an important tool for researchers investigating cancer biology and the mechanisms of antifungal defense. -
Macrolide Antibiotic
Oligomycin C is a macrolide antibiotic that specifically inhibits ATP synthase, thereby disrupting mitochondrial function. This compound demonstrates potent antifungal activity against a range of pathogens, including Aspergillus niger, Alternaria alternata, Botrytis cinerea, and Phytophthora capsici, making it a valuable tool for studying fungal infections and mitochondrial bioenergetics. Its selective action on fungi, with no antibacterial activity, further emphasizes its utility in antifungal research applications. -
Secondary Metabolite
Neosartoricin B is a secondary metabolite produced by Aspergillus nidulans. It has been shown to exert immunomodulatory effects, potentially influencing host interactions during fungal infections and colonization. This compound serves as a valuable tool in research focused on fungal pathogenesis and host defense mechanisms. -
Antifungal Agent
Antifungal Agent 98 primarily targets fungal pathogens and exhibits significant antifungal activity. At a concentration of 100 μg/mL, it demonstrates efficacy against various harmful fungi, including Bipolaris sorokinianum, Fusarium oxysporium f. sp. vasinfectum, Pyricularia oryzae, Alternaria brassicae, and Alternaria alternata, achieving death rates of 41.5%, 40.0%, 23.4%, 36.8%, and 35.0%, respectively. This compound is valuable for research focused on fungal control and plant health management. -
Antifungal Agent
Antifungal Agent 48 is a potent antifungal compound targeting Cryptococcus neoformans. Demonstrating a minimum inhibitory concentration (MIC) of 11 μM, it exhibits significant antifungal activity. This reagent is suitable for research applications focused on fungal infections and the development of antifungal therapies. -
Antifungal Agent
Caulilexin C is a phytoalexin derived from cruciferous plants that exhibits potent antifungal properties. It plays a significant role in plant defense by inhibiting the growth of various fungal pathogens. This compound is of particular interest in agricultural research for developing antifungal strategies and understanding plant-fungal interactions. -
Fungicide
Phenamacril is a potent fungicide that non-competitively inhibits myosin I activity, achieving an IC50 of 360 nM by suppressing ATPase activity. This compound demonstrates significant antifungal efficacy against Fusarium species, making it a valuable tool for research in fungal pathogenesis and the development of antifungal agents. -
Serine Palmitoyltransferase Inhibitor
Lipoxamycin is a potent serine palmitoyltransferase inhibitor, exhibiting an IC50 of 21 nM. This compound demonstrates significant antifungal activity, making it a valuable tool for studying lipid metabolism and sphingolipid biosynthesis. Lipoxamycin is applicable in research focused on fungal infections and potential avenues for therapeutic interventions targeting lipid-related pathways. -
Antifungal Agent
Voriconazole N-oxide is a potent antifungal agent primarily targeting fungal cell membrane biosynthesis. This compound exhibits both phototoxic and photocarcinogenic properties, which are important considerations in its biological evaluation. Additionally, Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB), making it relevant for studies in dermatological applications and the investigation of keratinocyte response to UV exposure. -
Antibacterial Compound
Di-O-methylhonokiol is a natural phenolic compound with notable antibacterial properties. It exhibits significant activity against Gram-positive bacteria, acid-fast bacilli, and various yeast and filamentous fungi. This compound is valuable for research applications focused on fungal infections and the development of antibacterial agents. -
Antibacterial Agent
(±)9-HpODE is a long-chain lipid hydroperoxide derived from the peroxidation of linoleic acid. This compound can induce the oxidation of intracellular glutathione (GSH), leading to alterations in cellular redox state. Additionally, (±)9-HpODE demonstrates antibacterial and antifungal activity, making it a valuable reagent for research into microbial pathogenesis and oxidative stress responses.
