(-)-Mitorubrinic acid is a polyketide that serves as a virulence factor for Penicillium marneffei. It is synthesized through the activity of two non-reducing polyketide synthase (PKS) genes, pks12 and pks11, operating in a sequential manner. This compound enhances the intracellular survival of P. marneffei within macrophages, making it significant for research on fungal pathogenesis and virulence mechanisms.
(-)-Mitorubrinic acid is a polyketide that serves as a virulence factor for Penicillium marneffei. It is synthesized through the activity of two non-reducing polyketide synthase (PKS) genes, pks12 and pks11, operating in a sequential manner. This compound enhances the intracellular survival of P. marneffei within macrophages, making it significant for research on fungal pathogenesis and virulence mechanisms.
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