Catalog No.
Product Name
Application
Product Information
Citations
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Antibiotic
BO-1236 is an antibiotic compound that exhibits potent antibacterial activity, particularly against Gram-negative bacteria, including Pseudomonas aeruginosa. This compound demonstrates in vitro and in vivo efficacy that is either superior to or comparable with some standard antibiotics. Additionally, BO-1236 shows stability against β-lactamase, making it a valuable tool for research applications targeting bacterial infections. -
Antibiotic
Deacetylravidomycin N-oxide is an antibiotic derived from Streptomyces ravidus S50905, primarily targeting Gram-positive bacteria while exhibiting no activity against Gram-negative strains. This compound demonstrates significant antitumor effects, particularly against P388 leukemia and methamphetamine A fibrosarcoma models. Its biological properties make it a valuable tool for research in microbiology and cancer studies. -
Antibiotic
Drimentine C is a terpenylated diketopiperazine antibiotic that targets bacterial proliferation. This compound demonstrates significant cytotoxicity, inhibiting the growth of NS-1 murine β lymphocyte myeloma cells by 63% and 98% at concentrations of 12.5 μg/mL and 100 μg/mL, respectively. Drimentine C can be utilized in research focused on antibiotic mechanisms and the evaluation of antitumor activities. -
Precursor Form
Oseltamivir acid methyl ester hydrochloride is a precursor to the neuraminidase inhibitor oseltamivir acid, which exhibits antiviral activity against influenza viruses. Upon administration, it is metabolized by carboxylesterase 1 (CES1) to yield oseltamivir acid, facilitating its therapeutic effects. This reagent is primarily utilized in research applications focused on antiviral drug development and metabolic studies involving oseltamivir. -
Antibacterial Agent
Temafloxacin hydrochloride is an orally active quinolone that functions as a broad-spectrum antibacterial agent. This compound demonstrates significant efficacy against various bacterial strains, making it suitable for the treatment of lower respiratory and genitourinary tract infections. Temafloxacin hydrochloride's well-tolerated profile further supports its potential applications in clinical research related to bacterial infection management. -
Bacterial Inhibitor
Surgumycin is a bacterial inhibitor that exhibits notable antimicrobial activity. Its mechanism involves disrupting essential cellular processes in bacteria, making it a valuable tool for studying bacterial infections and resistance mechanisms. Surgumycin is particularly useful in research applications focused on antibiotic development and the exploration of microbial pathogenesis. -
Antitumor Antibiotic
Glycocinnasperimicin D is an antitumor antibiotic that functions as a glycoside cinnamyl imide histamine derivative. It demonstrates significant antimicrobial activity against both Gram-positive and Gram-negative bacteria. Furthermore, Glycocinnasperimicin D exhibits potent cytotoxicity against leukemia L1210 cells, with an IC50 value of 2.0 μg/mL, making it a valuable compound for research in cancer biology and antibiotic efficacy studies. -
Antibiotic
Loracarbef is a synthetic beta-lactam antibiotic belonging to the carbacephem class, exhibiting potent activity against a broad range of gram-positive and gram-negative bacteria. As an orally active, second-generation cephalosporin, Loracarbef is utilized in clinical settings for the treatment of various bacterial infections. Its mechanism involves inhibiting bacterial cell wall synthesis, making it an important agent in antibiotic research and therapeutic applications. -
Anticoccidial Antibiotic
Xanthoquinodin A1 is an anticoccidial antibiotic that features a novel xanthone-anthraquinone conjugate system. This compound exhibits potent activity against Eimeria spp., making it valuable for research related to coccidiosis management in livestock and poultry. Its unique structure allows for exploration in studies of antibiotic resistance and potential therapeutic applications in veterinary medicine. -
Fluoroquinolone Antibiotic
Tosufloxacin is a fluoroquinolone antibiotic that exerts its primary action by inhibiting bacterial DNA gyrase and topoisomerase IV. It demonstrates a broad spectrum of antibacterial activity against both gram-positive and gram-negative bacteria. Tosufloxacin is utilized in research applications aimed at studying bacterial infections and antibiotic resistance mechanisms. -
antibacterial
Temporin-GHc is an antimicrobial peptide primarily targeting bacterial organisms. It demonstrates significant antibacterial activity with an MBIC50 value of 6 μM and exhibits antibiofilm activity with an MBEC50 value of 25 μM at 24 hours. This compound is useful for research applications focused on bacterial inhibition and biofilm formation. -
Polypeptide Antibiotics
Polymyxin B2 Sulfate is a polypeptide antibiotic that exerts its antibacterial effects primarily against gram-negative bacteria. Its mechanism of action involves binding to lipopolysaccharide molecules on the bacterial cell membrane, leading to membrane disruption and leakage of cellular contents. This compound is valuable in antibiotic development and the treatment of drug-resistant bacterial strains. -
Antibiotic
Bactobolin is a potent antibiotic that targets multiple bacterial strains, including Escherichia coli, Salmonella, Shigella, Staphylococcus, and Bacillus subtilis, exhibiting minimum inhibitory concentrations (MICs) ranging from 0.3 to 6.25 μg/mL. In addition to its antibacterial properties, Bactobolin demonstrates antitumor activity against leukemia, with a lethal dose 50 (LD50) value ranging from 6.25 to 12.5 mg/kg. This dual functionality makes Bactobolin a valuable compound for research in both microbiology and oncology. -
Antibiotic
Carumonam disodium is a potent antibiotic that primarily targets bacterial cell wall synthesis, rendering it effective against a range of Gram-negative pathogens. This compound exhibits significant antibacterial activity, making it suitable for research applications focused on infectious disease treatment and antibiotic resistance mechanisms. However, caution is advised as Carumonam disodium has been reported to induce seizure activity in certain conditions. -
Antibacterial Agent
Moxalactam is a synthetic oxa-β-lactam antibiotic that targets bacterial cell wall synthesis. It exhibits a broad spectrum of antibacterial activity against both Gram-positive and Gram-negative aerobic and anaerobic bacteria. Moxalactam also effectively inhibits the production of β-lactamases, making it a valuable tool for research in antibiotic resistance and microbial pathogenesis. -
Antibiotic
Hordenine sulfate is a bioactive compound primarily known for its antibiotic properties. It exhibits significant melanin-inhibiting activity by reducing intracellular cAMP levels and decreasing melanin content. Hordenine sulfate effectively downregulates the expression of key proteins involved in melanogenesis, such as microphthalmia-associated transcription factor (MITF), tyrosinase, and tyrosinase-related proteins (TRP-1 and TRP-2). This makes Hordenine sulfate a valuable reagent for research in dermatological studies focusing on pigmentation and related disorders. -
Antibiotic
Clindamycin Sulfoxide is an active metabolite of the antibiotic clindamycin, primarily generated through S-oxidation via the cytochrome P450 isoform CYP3A4. This compound exhibits significant antibacterial activity, effectively inhibiting the growth of anaerobic bacteria, including Peptostreptococcus prevotti, Bacteroides fragilis, and Clostridium sordelli, with minimal inhibitory concentration (MIC) values of 2 mg/L, 2 mg/L, and 1 mg/L, respectively. Clindamycin sulfoxide serves as a valuable tool for research applications focused on antibiotic efficacy and resistance mechanisms. -
Antibacterial Agent
Antofloxacin hydrochloride is a broad-spectrum 8-amino-fluoroquinolone that functions as an antibacterial agent. It demonstrates potent activity against gyrA mutation-positive Helicobacter pylori strains, notably the Asn87 mutant, where it surpasses the efficacy of levofloxacin. Additionally, Antofloxacin hydrochloride acts as a weak, reversible inhibitor of CYP1A2, making it a valuable reagent for studying infections caused by a variety of bacterial species. -
Peptide Antibiotic
A83586C is a novel peptide antibiotic that specifically targets Gram-positive bacteria. It exhibits potent antibacterial activity, making it a valuable tool for studying bacterial infections and developing new therapeutic strategies. Its unique mode of action allows researchers to explore mechanisms of resistance and efficacy in various biological contexts. -
Macrolide Antibiotic
Macrosphelide A is a macrolide antibiotic that exhibits potent antimicrobial activity against a range of fungal pathogens, including ascomycetes, basidiomycetes, and oomycetes. It effectively inhibits the growth of all tested Gram-positive bacteria, including the clinically relevant Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of ≤500 μg/mL. This compound is valuable for research applications aimed at exploring new antibacterial and antifungal therapeutics. -
Antibiotic
Antibiotic A40104A is an antimicrobial agent that targets bacterial cell wall synthesis. It demonstrates significant antibacterial activity against a broad spectrum of gram-positive and gram-negative organisms. This compound is suitable for use in microbiological research, including studies on antibiotic resistance mechanisms and the development of new antibacterial therapies. -
Antibiotic
Dihydrostreptomycin (DHSM) is an aminoglycoside antibiotic that primarily targets Gram-negative bacteria. It demonstrates significant antibacterial activity and is commonly utilized in research focused on the mechanisms of antibiotic resistance. Due to its ototoxic effects, which can cause irreversible damage to inner ear hair cells, it serves as a valuable model for investigating hearing loss and its underlying biological pathways. -
Antibiotic
Nanaomycin αA is an antibiotic known for its antimicrobial activity. Isolated from the fermentation broth of Streptomyces hebeiensis, this compound exhibits efficacy against various bacterial strains. Its unique properties make it valuable for research applications in microbiology and the development of new antibacterial agents. -
Antibacterial Agent
Antibacterial Agent 221 is a potent inhibitor specifically targeting Gram-positive Methicillin-resistant Staphylococcus aureus (MRSA). This compound exhibits significant antibacterial activity, demonstrating effectiveness against resistant strains. Additionally, Antibacterial Agent 221 shows pronounced cytotoxicity against human LO2 and HepG2 cells, making it a valuable tool for research in antimicrobial resistance and cytotoxic effects. -
Antibiotic
Quinaldopeptin is a quinomycin antibiotic derived from the culture of Streptoverticillium album that exhibits significant activity against Gram-positive bacteria and anaerobic pathogens. In addition to its antibacterial properties, Quinaldopeptin demonstrates potent cytotoxic effects on cultured B16 melanoma cells. This compound is valuable for research applications focusing on antimicrobial resistance and cancer therapeutics. -
Antibacterial Agent
Nifurtoinol is a nitrofuran-derived antibiotic that exerts antibacterial activity. It is primarily investigated for its effectiveness against urinary tract infections, making it a valuable compound for research in infectious disease studies and antibiotic development. -
Antibiotic
A-39183A is a potent antibiotic that exerts significant cytotoxic effects on HeLa cells, demonstrated by an IC50 value of 1.8 μM. This compound's mechanism of action may offer valuable insights into antimicrobial properties and cellular response pathways. A-39183A is suitable for research applications focused on studying antibiotic resistance and cell viability in cancer models. -
Antibiotic
Baquiloprim is an antibiotic that selectively inhibits bacterial dihydrofolate reductases. It demonstrates in vitro bacteriostatic activity against a variety of both Gram-negative and Gram-positive bacteria. Baquiloprim is utilized in research applications focused on understanding bacterial resistance and the mechanisms of folate metabolism in microbial pathogens. -
Antitumor Antibiotic
Alcindoromycin is an anthracycline antitumor antibiotic that exerts its effects primarily through the inhibition of topoisomerase II and intercalation into DNA. This compound demonstrates significant cytotoxic activity against various cancer cell lines, making it a valuable tool in cancer research. Alcindoromycin is utilized to investigate the mechanisms of chemoresistance and to evaluate potential therapeutic strategies for various malignancies. -
Antibiotic
Albomycin δ1 is a selective antibiotic that targets bacterial ribosomes, demonstrating bactericidal activity through covalent binding to 70S ribosomes and irreversible inhibition of peptidyl transferase. With an MIC of 0.0625 μg/mL against Streptococcus pneumoniae, this compound shows potential for research into infections caused by S. pneumoniae and Staphylococcus aureus. Its unique mechanism of action makes Albomycin δ1 a valuable tool in the study of ribosome-targeted therapeutics. -
Bacterial Inhibitor
LL-BM123α is a bacterial inhibitor derived from Nocardia sp., with a primary mechanism of action targeting Gram-negative bacteria. This compound demonstrates moderate antimicrobial activity, making it a valuable tool in research focused on bacterial infections and antibiotic resistance. LL-BM123α can be utilized in studies aimed at understanding the efficacy of novel antibiotics and developing strategies for overcoming bacterial resistance. -
Antibiotic
Actagardin is a tetracyclic lantibiotic that effectively targets Gram-positive bacteria by inhibiting peptidoglycan synthesis. This compound is characterized by its unique macrocyclic structure, formed through thioether bridges. Actagardin is utilized in research for its antibiotic properties, providing insights into bacterial resistance mechanisms and potential therapeutic applications. -
Cephalosporin Antibiotic
Cephradine sodium is a broad-spectrum cephalosporin antibiotic that demonstrates efficacy against both gram-positive and gram-negative bacteria, including penicillinase-producing strains. Its primary mechanism involves disrupting bacterial cell wall synthesis, leading to cell lysis and death. This reagent is utilized extensively in research focusing on genitourinary, gastrointestinal, and respiratory tract infections, as well as infections of the skin and soft tissues. Additionally, Cephradine sodium has been shown to inhibit TOPK, providing a potential therapeutic avenue for managing solar-ultraviolet induced skin inflammation. -
Antibiotic
PTZ601 is an antibiotic that targets gram-positive bacteria, effectively inhibiting strains such as Vancomycin-resistant Enterococcus faecium (VREF) and Methicillin-resistant Staphylococcus aureus (MRSA). This compound demonstrates significant antimicrobial activity in infected mouse models, making it a valuable tool for research in bacterial resistance and therapeutic development. Its application in preclinical studies may provide insights into potential treatments for resistant bacterial infections. -
Tetracycline Antibiotic
Demeclocycline calcium is a tetracycline antibiotic that primarily inhibits protein synthesis by binding to the 30S ribosomal subunit, preventing the attachment of aminoacyl tRNA. This compound exhibits a broad spectrum of antibacterial activity, making it useful in the treatment of various bacterial infections. Demeclocycline calcium is frequently utilized in research applications to study bacterial resistance and protein synthesis mechanisms. -
Antibiotic
Teicoplanin A2-3 is an antibiotic that primarily targets Gram-positive bacteria, including both aerobic and anaerobic strains. It exhibits potent antibacterial activity by inhibiting cell wall synthesis, making it effective in treating various infections caused by susceptible microorganisms. This reagent is valuable for research applications focused on antibiotic resistance, microbial pathogenesis, and the development of novel antibacterial therapies. -
Antibiotic
Malioxamycin is an antibiotic that targets Gram-negative bacteria by inhibiting peptidoglycan synthesis in bacterial cell walls. This mechanism disrupts bacterial cell wall integrity, leading to the formation of spheroplasts and subsequently causing cell lysis. Malioxamycin is applicable in research related to antibiotic resistance and bacterial cell wall biology. -
Antibiotic
Desotamide is a cyclic hexapeptide antibiotic that targets bacterial cell membrane integrity. It demonstrates potent activity against Staphylococcus aureus, Streptococcus pneumoniae, and methicillin-resistant Staphylococcus epidermidis (MRSE), with minimum inhibitory concentrations of 16, 12.5, and 32 μg/mL, respectively. This compound is useful for research applications related to antibiotic activity and resistance mechanisms in pathogenic bacteria. -
Antibiotic
Teicoplanin A3-1 is a glycopeptide antibiotic that targets Gram-positive bacteria. It is a degradation product of teicoplanins A2-1 to 5, showcasing broad-spectrum antibacterial activity. This compound is pivotal in research applications involving the effectiveness of glycopeptide antibiotics against resistant bacterial strains. -
Antibacterial, Biofilm Formation Inhibitor
Majoranaquinone is a potent antibacterial agent that targets various bacterial strains, demonstrating significant inhibitory effects against four Staphylococcus species, one Moraxella species, and one Enterococcus species. Additionally, it exhibits substantial efflux pump inhibitory activity in Escherichia coli ATCC 25922. Majoranaquinone also effectively inhibits biofilm formation in both E. coli ATCC 25922 and E. coli K-12 AG100, making it a valuable reagent for research applications focused on combating bacterial infections and biofilm-related challenges. -
Antibiotic
Antibacterial agent 159 is a broad-spectrum antibiotic that targets bacterial infections. It exhibits efficacy against impetigo and Clostridium difficile infections (CDI), demonstrating complete absence of recurrence for CDI while preserving the integrity of beneficial gut microbiota. This compound is valuable for research applications focusing on antibiotic resistance and the management of C. difficile-associated diseases. -
Antibiotic Peptide
BMAP-28 is an antibiotic peptide that acts as an inducer of the mitochondrial permeability transition pore. It triggers cell death by promoting the opening of this pore, making it a valuable tool for studying microbial infections and cancer mechanisms. Researchers can utilize BMAP-28 to explore its potential therapeutic applications and the underlying processes involved in cell apoptosis. -
Antibacterial Metabolite
Monomethylsulochrin is a potent antibacterial metabolite derived from the endophytic fungus Aspergillus fumigatus, isolated from the leaves of Albizia lucidior. This compound demonstrates significant antibacterial activity against Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 31.25 μg/mL. Monomethylsulochrin serves as a valuable tool for research applications focused on exploring novel antimicrobial agents and mechanisms of bacterial resistance. -
Bacterial Inhibitor
Lauryl-LF 11 is an N-terminally acylated analogue of LF11 that acts as a bacterial inhibitor. This peptide demonstrates significant antibacterial activity, making it a valuable tool for research in microbiology and infectious diseases. It can be utilized in studies focused on the mechanisms of bacterial resistance and the development of novel antimicrobial agents. -
Antibacterial Agent
FK-041 is an orally active cephalosporin antibiotic that targets penicillin-binding proteins (PBPs) to exert its antibacterial effects. It demonstrates broad-spectrum activity against a variety of pathogens, including both Gram-positive and Gram-negative bacteria as well as anaerobes. Additionally, FK-041 shows efficacy against certain drug-resistant strains, such as penicillin-resistant Streptococcus pneumoniae. This reagent is valuable for research focused on infectious diseases and the development of new antibacterial therapies. -
Bacterial Inhibitor
Citreamicin alpha is a potent bacterial inhibitor demonstrated to exhibit significant antimicrobial activity against a range of Gram-positive cocci. In vitro studies reveal that MIC values for Staphylococci range from 0.12-4.0 μg/ml, and for Streptococcus pyogenes, they range from 0.03-0.12 μg/ml. While Citreamicin alpha shows superior efficacy compared to ampicillin, amoxicillin, and ceftriaxone, it exhibits comparable effects to vancomycin. Its effectiveness against various strains makes it a valuable reagent for research in antibiotic development and resistance studies. -
Antibiotic
CK0683A is a novel biaminourea antibiotic that targets bacterial plaque formation. Demonstrating significant antiplaque effects, this compound has shown efficacy in experimental mouse models of dental disease. In a 12-week study, CK0683A was evaluated in beagles for its potential to reduce plaque and gingivitis while assessing safety and staining potential. The canine model is relevant, as the onset and progression of periodontal disease in dogs parallels that in humans, making CK0683A a promising candidate for further research in periodontal treatment. -
Antibiotic
Aztreonam (lysine) is a monocyclic beta-lactam antibiotic that specifically targets penicillin-binding protein 3 (PBP-3). It exhibits potent activity against Gram-negative aerobic bacteria, making it an important reagent for studies involving bacterial resistance and the development of antimicrobial therapies. This compound is particularly relevant in research focused on combating infections caused by resistant strains and understanding the mechanisms of beta-lactam antibiotics. -
Antibiotic/Antimicrobial Peptide
Aurein 2.4 is an antibiotic antimicrobial peptide that primarily targets Gram-positive bacteria. It exhibits potent antibacterial activity, making it a valuable reagent for research focused on antimicrobial resistance and the development of novel antibacterial therapies. Its unique mechanism of disrupting bacterial membranes positions Aurein 2.4 as a relevant tool in studies investigating the efficacy of peptide-based antibiotics. -
Antibiotic
Cefmenoxime is a semisynthetic cephalosporin antibiotic targeting bacterial cell wall synthesis. It exhibits broad-spectrum antibacterial activity against a wide variety of gram-positive and gram-negative bacteria. This compound is primarily applied in microbiological research and antibiotic susceptibility studies.
