MRL-494 hydrochloride is an antibacterial agent that functions as an inhibitor of the β-barrel assembly machine A (BamA), effectively circumventing efflux and the outer membrane permeability barrier. It exhibits significant antibacterial activity against Gram-positive bacteria, with a minimum inhibitory concentration (MIC) of 12.5 μM for Staphylococcus aureus COL, and against Gram-negative bacteria, with an MIC of 25 μM for Escherichia coli JCM158. This compound is suitable for research applications focused on combating bacterial infections and studying membrane protein assembly.
MRL-494 hydrochloride is an antibacterial agent that functions as an inhibitor of the β-barrel assembly machine A (BamA), effectively circumventing efflux and the outer membrane permeability barrier. It exhibits significant antibacterial activity against Gram-positive bacteria, with a minimum inhibitory concentration (MIC) of 12.5 μM for Staphylococcus aureus COL, and against Gram-negative bacteria, with an MIC of 25 μM for Escherichia coli JCM158. This compound is suitable for research applications focused on combating bacterial infections and studying membrane protein assembly.
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