Catalog No.
Product Name
Application
Product Information
Citations
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Recombinant Bacterial Clones Chromogenic Substrate
X-GalNAc is a chromogenic substrate that specifically targets N-acetyl-β-galactosidase. This reagent is utilized in molecular biology to detect the presence of cloned DNA inserts in bacterial colonies cultured on agar plates. The enzymatic hydrolysis of X-GalNAc results in a distinct color change, facilitating easy identification of recombinant bacterial clones in various genetic research applications. -
SARS-CoV-2 Inhibitor
TFMU-ADPr is a selective reporter substrate that targets the SARS-CoV-2 Macro1 protein, displaying an IC50 of 0.59 μM. This compound emits fluorescence at 502 nm (or 495 nm) upon enzymatic hydrolysis by Poly(ADP-ribose) Glycohydrolase (PARG) and ADP-ribosylhydrolase 3. TFMU-ADPr binds to the ADPr-binding site of Macro1, providing a robust method for assessing the activity of poly(ADP-ribose) hydrolases. Its applications extend to evaluating small-molecule inhibitors under in vitro conditions, investigating ADP-ribosyl catabolic enzyme mechanisms, and detecting PAR hydrolase activity in whole-cell lysates, making it a valuable tool for COVID-19-related research. -
Bacterial Inhibitor
Resazurin sodium is a non-toxic, stable redox indicator that targets bacterial activity through its membrane-permeable properties. It serves as a vital tool for assessing cell viability, proliferation, and toxicity in various cell types, including human, plant, animal, bacterial, and fungal cells. Upon reduction, Resazurin sodium transforms into Resorufin, a highly fluorescent compound, enabling sensitive detection and quantification of cellular processes under fluorescent microscopy or spectrophotometry. -
SARS-CoV Inhibitor
Direct Violet 1 is an azo dye that functions as an inhibitor of the spike protein-ACE2 interaction in SARS-CoV-2, exhibiting IC50 values ranging from 1.47 to 2.63 μM. This compound serves as a valuable tool for investigating viral entry mechanisms and studying protein-protein interactions related to SARS-CoV-2. Its application may extend to antiviral research and the development of therapeutic strategies targeting COVID-19. -
Antibacterial Agent
ANS ammonium is a potent antibacterial agent that also serves as a textile dye. It functions as a fluorescence probe, enabling the detection of various biological interactions. Additionally, ANS ammonium is known to inhibit the binding of triiodothyronine to thyroxine binding globulin, making it useful in radioimmunoassays for triiodothyronine analysis. -
Antiviral Agent
Brilliant Black BN is an azo dye with a notable application as an antiviral agent. It effectively inhibits the interaction between enterovirus 71 (EV71) and its uncoating factor, cyclophilin A, demonstrating significant potential in the treatment of viral infections. This compound serves as a valuable tool for research focused on antiviral mechanisms and infectious disease studies. -
Bacterial Inhibitor
4-Methylherniarin, a coumarin derivative, exhibits antibacterial activity by effectively inhibiting both gram-positive and gram-negative bacterial strains. It demonstrates significant antimicrobial efficacy against B. subtilis and S. sonnei, with IC50 values of 11.76 μg/ml and 13.47 μg/ml, respectively. This compound serves as a valuable tool for research applications focused on combating bacterial infections and elucidating mechanisms of action in microbial resistance. -
Antibiotic Agent
Polyketomycin is a tetracyclic quinone glycoside antibiotic derived from Streptomyces sp. or Streptomyces diastatochromogenes, targeting Gram-positive bacteria with a minimal inhibitory concentration (MIC) of less than 0.2 µg/mL. This compound exhibits notable antibacterial, anticancer, and antimalarial activities, making it a valuable tool in microbiological and pharmacological research. Its diverse biological applications support investigations in antibiotic efficacy, cancer treatment, and antimalarial drug development. -
Antitumor Antibiotic
Sandramycin is a cyclic depsipeptide antibiotic with a primary mechanism of action as an antitumor agent. It exhibits potent DNA intercalation and binding, functioning effectively as a cytotoxin in antibody-drug conjugates (ADCs). Sandramycin demonstrates significant activity against Gram-positive bacteria and is recognized for its strong antitumor efficacy, making it a valuable reagent for cancer research and the development of targeted therapies. -
Dengue Protease Inhibitor
Carbonic anhydrase inhibitor 16 is a potent dengue protease inhibitor that targets human carbonic anhydrases I and II, exhibiting inhibitory constants (Ki) of 28.5 nM and 2.2 nM, respectively. This compound demonstrates significant biological activity in hindering dengue virus replication by disrupting protease function. It may be utilized in research applications aimed at elucidating mechanisms of dengue virus pathogenesis and developing antiviral therapeutics. -
Bacterial Inhibitor
Procodazole is a potent bacterial inhibitor that enhances immune response, offering protection against various viral and bacterial infections. In addition to its broad-spectrum antibacterial effects, Procodazole demonstrates antiparasitic activity and serves as a carbonic anhydrase inhibitor, contributing to its antitumor properties. This compound is suitable for research applications focused on infectious diseases and cancer biology. -
Nucleoside Antibiotic
Dealanylascamycin is a nucleoside antibiotic that functions as a carbonic anhydrase (CA) inhibitor, exhibiting Ki values of 167, 65.2, 234, and 143 nM for human CA isoforms I, II, IV, and IX, respectively. This compound demonstrates broad-spectrum antibacterial activity, notably effective against pathogens such as Xanthomonas citri with a minimum inhibitory concentration (MIC) of 0.4 μg/mL. Additionally, Dealanylascamycin displays significant cytotoxicity, making it a substance of interest for various biological research applications, particularly in the study of antimicrobial effects and CA inhibition. -
HIV Inhibitor
ZL0580 is an HIV inhibitor that functions by selectively binding to the BD1 domain of BRD4, leading to epigenetic suppression of the virus. This compound effectively inhibits Tat transactivation and transcription elongation while promoting a repressive chromatin structure at the HIV promoter. ZL0580 is valuable for research applications focused on HIV therapies and the mechanisms of viral transcription regulation. -
HIV-1 LRA
UMB-136 is a bromodomain inhibitor targeting HIV-1 latency. It serves as a promising latency-reversing agent (LRA) for the eradication of HIV-1, effectively reactivating the virus in various cell models. UMB-136 enhances HIV-1 transcription and promotes viral production by facilitating the release of P-TEFb, thereby contributing to research in HIV treatment strategies. -
Phytoestrogen
3,7-Dihydroxyflavone is a flavonoid phytoestrogen that modulates estrogen receptors, making it a valuable compound for research in hormonal signaling pathways. It serves as an inhibitor of the human progesterone metabolizing enzyme AKR1C1 and fungal 17β-hydroxysteroid dehydrogenase, demonstrating redox inhibitory activity with IC50 values of 0.6 μM and 6.0 μM, respectively. Additionally, 3,7-Dihydroxyflavone exhibits fluorescence properties, acting as a binding substrate for human serum albumin with specific excitation and emission wavelengths, rendering it useful for biochemical assays and studies related to protein binding interactions. -
Bacterial Metabolite
12-Tridecenoic acid is a bacterial metabolite that plays a crucial role in the regulation of lipid metabolism. It promotes the expression of acetyl-CoA carboxylase α (ACC) while inhibiting carnitine palmitoyltransferase 1A (CPT1A), contributing to the development of hepatic steatosis. This compound is relevant for research in metabolic diseases and cellular lipid regulation. -
Antibacterial Agent
Metioprim is a competitive inhibitor of bacterial dihydrofolate reductase (DHFR), targeting critical pathways in bacterial folate metabolism. It exhibits potent antibacterial activity against anaerobic bacteria and demonstrates synergistic effects when combined with DDS against E. coli and various mycobacterial strains. This reagent is valuable for antibacterial research and development, particularly in studies focused on antibiotic resistance and the efficacy of combination therapies. -
Antibacterial Agent
AR-102 is an antibacterial agent that exhibits potent inhibitory activity against Staphylococcus aureus. It demonstrates competitive inhibition of the F98Y mutant dihydrofolate reductase (DHFR) with a Ki value of 0.22 nM. Structural studies have characterized AR-102 as forming a ternary complex with NADPH in both wild-type and TMP-resistant F98Y mutant S. aureus DHFR, making it a valuable compound for research on antibacterial resistance mechanisms. -
Antibiotic
Cefamandole lithium is a second-generation broad-spectrum cephalosporin antibiotic that exerts its antibacterial activity by inhibiting bacterial cell wall synthesis. This compound is effective against a variety of Gram-positive and Gram-negative bacteria. Upon metabolism, cefamandole lithium releases free N-methylthiotetrazole (NMTT), which may result in low prothrombinemia, highlighting its importance in biochemical and pharmacological research applications. -
Antibiotic
Resorcinomycin A is an antibiotic primarily targeting mycobacterial species, demonstrating potent anti-mycobacterial activity. This compound exhibits weaker activity against mycoplasma, making it a valuable reagent for research applications focused on mycobacterial infections and mechanisms of action within this class of pathogens. -
Antitumor Antibiotic
IB-96212 is an antitumor antibiotic derived from the marine bacterium Micromonospora sp. It primarily targets cancer cells, demonstrating potent activity against the P-388 leukemia cell line. Additionally, IB-96212 exhibits antimicrobial properties against Micrococcus luteus, making it a valuable compound for various research applications in cancer and microbiology studies. -
Anti-Candidal Agent
Callophycin A is a natural metabolite derived from red seaweed, demonstrating strong antifungal activity against Candida albicans, with a minimum inhibitory concentration (MIC) of 62.5–250 mg/L. This compound effectively diminishes fungal load in models of vaginal candidiasis and is associated with reduced inflammatory responses and modulation of immune molecules. Callophycin A is valuable for research applications focusing on antifungal therapies and the immune responses associated withCandida infections. -
Antibiotic
A-83016F is an antibiotic compound with activity derived from an unidentified actinomycete designated A83016. This compound exhibits weak antimicrobial properties and is primarily used for research applications exploring antibiotic efficacy and microbial resistance mechanisms. Further investigation of A-83016F may provide insights into its potential therapeutic applications and bacteriologic interactions. -
Antibiotic
TS 155-2 is an antibiotic that acts as an analogue of Bafilomycin, functioning primarily through the inhibition of V-ATPase activity. This enzyme is critical for various cellular processes and has been associated with a range of diseases, including osteopetrosis, male infertility, and renal acidosis. TS 155-2 is valuable for research applications focusing on antimicrobial effects and the physiological roles of V-ATPase in disease contexts. -
Penicillin Antibiotic
Pivampicillin is a penicillin antibiotic that acts as a prodrug of ampicillin. Upon metabolism, it converts to ampicillin, exerting bactericidal activity against a broad range of Gram-positive and some Gram-negative bacteria. This compound is commonly utilized in research applications focused on studying bacterial infections and antibiotic resistance mechanisms. -
Antibiotic
Gentamicin C2 is an aminoglycoside antibiotic that targets bacterial protein synthesis by binding to the 30S ribosomal subunit. It exhibits potent activity against a wide range of gram-negative bacteria, making it a valuable tool in microbial research and clinical applications. Gentamicin C2 is commonly utilized in studies investigating antibiotic resistance and the mechanisms of bacterial pathogenesis. -
Antibiotic
Dedesosaminyl-5-O-mycaminosyl-10,11-dihydromycinamicin IV is a potent antibiotic targeting bacterial protein synthesis. Its mechanism involves inhibiting the activity of the ribosomal machinery, leading to decreased protein production in susceptible bacteria. This compound is primarily utilized in research applications focused on antibiotic resistance and the development of novel antimicrobial therapies. -
Antibiotic
Phenelfamycin E is an elfamycin-type antibiotic that targets and exhibits activity against Gram-positive anaerobes, including Clostridium difficile. Its potent antibacterial properties make Phenelfamycin E a valuable tool for research applications focused on combating bacterial infections and studying antibiotic resistance mechanisms. -
Antibiotic
Formycin B is an antibiotic that primarily targets and exhibits antiparasitic activity against Leishmania species. It has been shown to induce cytotoxic effects on leukocytes, leading to a reversible decrease in neutrophil populations. This compound is valuable for research applications related to myeloid leukemia and can aid in the exploration of therapeutic pathways involving immune modulation. -
Antibiotic
Streptochlorin is an antibiotic compound with demonstrated antitrypanosomal activity, exhibiting an IC50 value of 230 ng/ml against the GUTat 3.1 strain. It is a valuable tool for research applications focused on the treatment of trypanosomiasis and the exploration of antibiotic mechanisms. -
Antibiotic
Setomimycin is a potent antibiotic that targets the SARS-CoV-2 main protease (Mpro) with an IC50 value of 12.02 µM. In addition to its antibacterial properties, Setomimycin exhibits anti-inflammatory and antioxidant effects. It also demonstrates significant antiproliferative and antitumor activity, making it a valuable reagent for research in infectious diseases and cancer biology. -
Antibiotic
Spergualin trihydrochloride is a naturally occurring antibiotic derived from the culture filtrates of Bacillus laterosporus BMG162-aF2. It exhibits significant antimicrobial activity, targeting a range of bacterial pathogens. This compound is utilized in research to explore antibiotic mechanisms and develop novel therapeutic strategies against bacterial infections. -
Antibiotic/Antimicrobial Peptide
Aurein 5.2 is an antimicrobial peptide with potent antibiotic properties. It exhibits broad-spectrum activity against various bacterial strains, making it a valuable tool in studies related to infection control and antibiotic resistance. Its mechanism of action involves disrupting bacterial cell membranes, leading to cell lysis. Aurein 5.2 is applicable in research focused on antimicrobial development and the understanding of peptide-based therapeutics. -
Antibiotic
TPU-0037A is an antibiotic that acts as a congener of lydicamycin, specifically targeting Gram-positive bacteria. It effectively inhibits the growth of methicillin-resistant Staphylococcus aureus (MRSA), Bacillus subtilis, and Micrococcus luteus, with minimum inhibitory concentrations (MICs) ranging from 1.56 to 12.5 μg/mL. Notably, TPU-0037A shows no efficacy against Gram-negative strains such as Escherichia coli, Proteus mirabilis, Proteus vulgaris, or Pseudomonas aeruginosa, with MICs exceeding 50 μg/mL. This compound is valuable for research applications focused on antibiotic resistance and the mechanisms of bacterial growth inhibition. -
Antibacterial Agent
10-Decarbamoyloxy-9-dehydromitomycin B is a derivative of mitomycin with notable antibacterial properties. This compound exhibits significant antibacterial and antitumor activities, making it a valuable tool for research in infectious diseases and cancer treatment. Its mechanism of action involves DNA crosslinking, leading to inhibition of replication and cell division, thereby providing insights into therapeutic potential and resistance mechanisms. -
Antibiotic
Levonadifloxacin arginine hydrate is a broad-spectrum antibiotic targeting staphylococcal infections. It demonstrates significant antibacterial activity against both methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) strains. This compound is particularly effective in reducing bacterial load when phagocytized by THP-1 monocytes, making it a valuable tool for research in infectious diseases and antimicrobial resistance. -
Antibiotic
Chartreusin is an antibiotic that targets specific Gram-positive bacteria and mycobacteria. It demonstrates effective antimicrobial activity against various strains, including Micrococcus fiyogenes v. aureus phage. Chartreusin is primarily utilized in research applications focused on antibacterial properties and the development of novel therapeutic agents. -
Penem Antibiotic
FCE-25199 is a penem antibiotic with oral bioavailability that exhibits potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria. Its effectiveness in combating bacterial infections makes it a valuable tool for research in microbiology and infectious disease studies. This compound aids in the exploration of antibiotic resistance mechanisms and the development of new therapeutic strategies. -
Antibacterial Agents
Sulfachloropyridazine sodium is a sulfonamide antibiotic that exerts its antibacterial activity through the inhibition of bacterial folic acid synthesis. This compound is effective against a range of Gram-positive and Gram-negative bacteria, making it useful for research in antibiotic efficacy and resistance mechanisms. Its application includes studying bacterial growth inhibition and exploring the therapeutic potential in various infectious diseases. -
Antibiotic
3-O-Demethylfortimicin A is an aminocyclitol antibiotic that exhibits significant antibacterial activity. It is particularly effective against Gram-negative pathogens as well as Staphylococcus species. This compound can be utilized in research applications focusing on antibiotic resistance and the development of new antimicrobial therapies. -
Bacterial Inhibitor
FR-202306 is a bacterial inhibitor that targets peptide deformylase, an enzyme crucial for bacterial protein synthesis. This compound displays significant antibacterial activity against Staphylococcus aureus by effectively inhibiting its peptide deformylase activity. FR-202306 is valuable for research applications focused on developing antibacterial agents and exploring mechanisms of bacterial resistance. -
Bacterial Inhibitor
LF11 is a peptide that functions as a bacterial inhibitor by disrupting microbial cell membrane integrity. It exhibits potent antibacterial activity, making it a valuable tool for research focused on combating bacterial infections and studying antimicrobial mechanisms. Its application is particularly relevant in the development of new therapies and understanding resistance in pathogenic bacteria. -
antibiotic
Colistin B sulfate is an antibiotic derived from the soil bacterium Bacillus polymyxa. It primarily targets bacterial membranes, disrupting their integrity and leading to cell death. Colistin B sulfate is commonly used in research to study antibiotic resistance mechanisms and the effectiveness of antimicrobial therapies against Gram-negative bacteria. -
Antibiotic
Dactimicin sulfate is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Derived from the bacterium Dactylosporangium matsuzakiense, it is part of the fortimicin antibiotic family. Dactimicin sulfate is valuable in research related to bacterial infections and can be used to investigate the effects on sensitive bacterial strains. Its unique structure and mechanism make it an important tool for studying antibiotic resistance and therapeutic applications. -
Antibiotic
Septamycin is a metal-complexing polyether antibiotic derived from the bacterium Streptomyces hygroscopicus NRRL 5678. This compound exhibits significant anticoccidial activity, making it useful in studying protozoan infections. Septamycin serves as a valuable reagent in research related to antibiotic development and the mechanisms of bacterial resistance. -
Antibiotic
Cinerubin B is a glycosylated anthracycline antibiotic that acts primarily as an anticancer agent. Derived from Streptomyces sp. SPB74, it exhibits significant cytotoxicity against a range of cancer cell lines. Cinerubin B is utilized in research for its potential therapeutic applications and to further understand its mechanism of action in cancer treatment. -
Antibacterial Agent
Antibacterial Agent 105 is a phenanthrolinic analog of quinolones that targets bacterial cell functions, demonstrating significant antibacterial activity against Mycobacterium tuberculosis with an MIC90 of 2.64 μM. This compound also exhibits broad-spectrum antibacterial efficacy against various bacterial species, including MIC90 values of 11.18 μM for M. smegmatis and M. aurum, 0.70 μM for M. marinum, 1.40 μM for BCG, 44.70 μM for Enterobacter aerogenes, and 22.35 μM for Staphylococcus aureus. Its diverse activity profile makes it a valuable tool for research in antimicrobial resistance and therapeutic interventions. -
Antibiotic
Cefalonium hydrate is a first-generation β-lactam cephalosporin antibiotic that primarily targets bacterial cell wall synthesis. It exhibits significant antibacterial activity against Gram-positive bacteria, making it an essential tool for research into bovine mastitis and related infections. This reagent is crucial for studying the efficacy of treatments and understanding the mechanisms of resistance in affected livestock. -
Antibiotic
Enterocin is an antibiotic that primarily targets gram-positive and certain gram-negative bacteria, exhibiting bacteriostatic activity. Due to its specificity, Enterocin shows no effectiveness against fungi and yeast. It is utilized in research applications focused on bacterial infections and the development of novel antimicrobial agents. -
Antibiotic Adjuvant
Antibiotic Adjuvant 1 is a chemical compound that functions as an antibiotic adjuvant by enhancing the efficacy of antibiotics. It has demonstrated minimal intrinsic antibacterial activity, with a minimum inhibitory concentration (MIC) greater than 128 µg/mL. Notably, it significantly potentiates the activity of Cloxacillin, achieving a 66-fold increase in effectiveness, indicating a strong synergistic effect. This compound is useful for research applications focused on antibiotic enhancement and the study of synergistic drug interactions.
