Catalog No.
Product Name
Application
Product Information
Citations
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β-lactamases
Cephalosporinase, bacillus is an enzyme that functions as a β-lactamase, inactivating and degrading the activity of cephalosporin antibiotics. This enzyme is essential for research on antibiotic resistance mechanisms in bacteria, as it allows the study of the efficacy of cephalosporins against resistant strains. It is useful in developing strategies to combat bacterial infections and improve antibiotic therapies. -
Bacterial Inhibitor
Aureothricin is a dithiolopyrrolone (DTP) antibiotic with a primary mechanism of inhibiting bacterial growth. It demonstrates broad-spectrum antibiotic activity and has the ability to impede the adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin. This compound is valuable for research applications focused on bacterial inhibition and the modulation of cell adhesion processes. -
Antibiotic
Sulfacytine is a short-acting sulfonamide antibiotic that exhibits antibacterial activity by inhibiting bacterial folic acid synthesis. It is primarily utilized in research focused on acute uncomplicated urinary tract infections, showcasing its effectiveness against various bacterial pathogens. This reagent is valuable for studies exploring antibiotic efficacy and mechanisms of resistance. -
Aminomethylcycline Antibiotic
Zifanocycline is a semisynthetic third-generation aminomethylcycline antibiotic that inhibits bacterial ribosome function. It demonstrates broad-spectrum in vitro antibacterial activity against both Gram-positive and Gram-negative bacteria, including numerous multidrug-resistant strains. Zifanocycline is applicable in the research of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections. -
Bacterial Inhibitor
Flomoxef is an oxacephem antibiotic that exerts its bactericidal effects primarily by inhibiting bacterial cell wall synthesis. It demonstrates significant activity against a range of Gram-positive bacteria. This compound is utilized in research settings to investigate antibiotic resistance mechanisms and to develop novel antibacterial agents. -
Antibiotic
3-Desacetyl Cefotaxime lactone is the active metabolite of the third-generation cephalosporin antibiotic Cefotaxime. This compound exhibits significant antibacterial activity against a broad spectrum of Gram-positive and Gram-negative bacteria. It is primarily utilized in research applications to study antibiotic efficacy, resistance mechanisms, and the pharmacokinetics of cephalosporin derivatives. -
Antibiotic
Rhodomyrtone is an antibiotic derived from the leaves of Rhodomyrtus tomentosa, specifically targeting Gram-positive bacteria. This compound exhibits bactericidal activity through a mechanism that does not induce bacteriolysis, effectively eliminating strains such as Bacillus cereus, Bacillus subtilis, Enterococcus faecalis, Staphylococcus epidermidis, Streptococcus gordonii, Streptococcus pneumoniae, Streptococcus pyogenes, and Streptococcus salivarius. Rhodomyrtone is suitable for research applications concerning bacterial infections and antimicrobial resistance studies. -
Antibiotic
Rifamycin B is an ansamycin antibiotic that primarily targets bacterial RNA polymerase, exhibiting significant anti-mycobacterial activity against pathogens such as Mycobacterium tuberculosis, leprosy, and various AIDS-related mycobacterial infections. Derived from the natural product of Nocardia inediterranei, Rifamycin B also serves as a precursor for the formation of Rifamycin O and Rifamycin S through microbial transformation. This compound is essential for research focused on antibiotic resistance and the treatment of mycobacterial diseases. -
Antibiotic
Streptazolin is an antibiotic that enhances bacterial clearance and promotes the secretion of immunostimulatory cytokines by macrophages in vitro. It activates the macrophage NF-κB pathway through the PI3K signaling cascade, contributing to its immunomodulatory effects. This compound is valuable for research applications aimed at understanding antibiotic efficacy and macrophage behavior in immune responses. -
Bacterial Inhibitor
Flucloxacillin is a β-lactam antibiotic that primarily targets bacterial cell wall synthesis by inhibiting transpeptidation enzymes. It exhibits potent antibacterial activity against a variety of gram-positive and some gram-negative bacteria, making it valuable in treating infections caused by staphylococci and streptococci. This reagent is widely utilized in microbiological studies and antibiotic susceptibility testing to evaluate bacterial resistance. -
Antibacterial Peptide
D2A21 is an antibacterial peptide derived from cecropins that exhibits potent antimicrobial activity. It has a minimum cidal concentration of 21.69 μg/mL against Chlamydia trachomatis, demonstrating its effectiveness in combating bacterial infections. This peptide is valuable for research applications aimed at developing novel antimicrobial therapies and studying bacterial resistance mechanisms. -
Antibiotic
Herbimycin A is an ansamycin antibiotic that serves as a potent inhibitor of Src family kinases. By binding to the SH domain, it effectively inhibits the activity of p60v-src and p210BCR-ABL, highlighting its relevance in cancer research. Additionally, Herbimycin A disrupts Hsp90 function and impedes cellular recovery from heat shock, while also demonstrating antiangiogenic properties in vitro in endothelial cells. This reagent is valuable for studies focusing on cellular stress responses and angiogenesis. -
Bacterial Inhibitor
Sulfadimethoxine-d6 is a deuterated form of Sulfadimethoxine, a sulfonamide antibiotic that acts as a bacterial inhibitor by interfering with folate synthesis in pathogenic microorganisms. This reagent is primarily utilized in pharmacokinetics and metabolic studies, allowing for improved tracking of the compound in biological systems. Its deuterium labeling enhances analytical sensitivity in various applications, including drug metabolism research and isolation studies. -
Antibiotic
DL-Lanthionine is an amino acid that functions as a crucial monosulfide analog of cystine. It serves as a key component in the structure of peptide antibiotics known as lantiobiotics, which include prominent members like nisin and subtilin. DL-Lanthionine is instrumental in researching antibiotic mechanisms and developing novel antimicrobial agents with therapeutic potential. -
Antibiotic
A-54556A (ADEP 1) is an acyldepsipeptide antibiotic that primarily targets bacterial protein synthesis. It exhibits potent antibacterial activity against a diverse array of Gram-positive bacteria, making it a valuable tool for research on bacterial resistance and antibiotic efficacy. A-54556A is utilized in studies exploring mechanism of action and the development of novel antimicrobial agents. -
Antibiotic
Carbenicillin is a semi-synthetic penicillin antibiotic that primarily targets gram-negative bacteria through the inhibition of cell wall synthesis. It exhibits broad-spectrum antibacterial activity and is characterized by its relatively low toxicity towards plant tissues. Carbenicillin is commonly utilized in microbiological research and clinical applications to study bacterial growth and resistance mechanisms. -
Dianionic Cephem Antibiotic
Ceftibuten is a dianionic cephem antibiotic that exhibits potent antibacterial activity. It is effective in vitro against a variety of gram-negative bacteria and certain gram-positive pathogens. This compound is primarily used in research applications focused on antibiotic resistance and the mechanism of action of cephalosporins. -
Antibiotic
Eremomycin is a potent glycopeptide antibiotic that targets bacterial cell walls to inhibit growth. It exhibits significant antibacterial activity against Staphylococcus species and Bacillus subtilis ATCC6633, with minimal inhibitory concentrations ranging from 0.03 to 1.6 μg/mL. This compound is valuable in research applications focused on antibiotic resistance and the development of new antibacterial therapies. -
antibiotic
Spiramycin III is a macrolide antibiotic derived from Streptomyces ambofaciens, primarily targeting bacterial infections and Toxoplasma gondii. This compound exhibits notable antibacterial and antiparasitic activities, making it a valuable reagent for research applications focused on infectious diseases and parasitic challenges. Its versatile efficacy positions Spiramycin III as a critical tool in the study and treatment of various microbial infections. -
Antibacterial Agent
Avilamycin C is an avilamycin-type antibiotic that targets bacterial cell wall synthesis. It exhibits potent antibacterial activity, particularly against Gram-positive bacteria, making it valuable in research focused on antibiotic resistance and bacterial infections. This compound serves as a crucial tool for studies investigating mechanisms of action and the development of novel antibacterial therapies. -
Antibiotic
Showdomycin is an antibiotic targeting bacterial ribosomes, inhibiting protein synthesis. It is produced by Streptomyces in response to the IM-2 inducer. Showdomycin exhibits potent antibacterial activity, making it valuable for research on microbial resistance mechanisms and the development of new antibiotic therapies. -
Secondary Metabolite
Aurofusarin is a secondary metabolite derived from the fungus Fusarium graminearum, known as a significant pathogen affecting vital crops in temperate regions. This compound exhibits antifungal properties and plays a role in the ecological interactions of plant-fungal systems. Aurofusarin is utilized in research to explore plant-pathogen interactions and the biosynthetic pathways of secondary metabolites. -
Antibiotic
Thiocillin I is a thiopeptide antibiotic that exhibits potent antibacterial activity against Gram-positive bacteria. It has been shown to have minimum inhibitory concentration (MIC) values of 2 μg/mL against Staphylococcus aureus, 0.5 μg/mL against Enterococcus faecalis, 4 μg/mL against Bacillus subtilis, and 0.5 μg/mL against Streptococcus pyogenes. Thiocillin I is primarily used in research applications focused on bacterial resistance and antibiotic efficacy studies. -
Antimicrobial Agent
11β,13-Dihydrolactucin serves as an antimicrobial agent, demonstrating significant antibacterial and antifungal properties. Additionally, this compound exhibits various biological activities, including antioxidant, anti-inflammatory, and antitumor effects. Its versatile nature makes it a valuable reagent for research applications in microbiology and cancer studies. -
Antibiotic
Gilvocarcin V is an antibiotic that targets bacterial cells, exhibiting strong antibacterial activity. Isolated from Actinomycete, it also demonstrates anti-tumor properties, making it a valuable reagent for cancer research. Its dual functionality supports investigations into microbial resistance and tumor biology, contributing significantly to the understanding of these critical areas. -
Antibiotic
Clovibactin is an antibiotic that effectively targets drug-resistant bacterial pathogens with no detectable resistance. This compound functions by inhibiting cell wall synthesis, specifically targeting the pyrophosphate of peptidoglycan precursors. Its unique mechanism makes Clovibactin a valuable tool for researching antibiotic resistance and developing new therapeutic strategies against challenging bacterial infections. -
Antibiotic
(5S)-Neosamine C is an aminocyclic alcohol antibiotic that targets bacterial cell wall synthesis through its unique cyclized structure. This compound is derived from microbial secondary metabolites and serves as a key precursor in the biosynthesis of Neomycins. Its biological activity highlights its potential applications in antibiotic research and development. -
β-lactam Antibiotic
Cefoselis is a fourth-generation cephalosporin that functions as a β-lactam antibiotic, targeting bacterial cell wall synthesis. It demonstrates potent activity against a broad spectrum of Gram-positive and Gram-negative bacteria. Additionally, Cefoselis is capable of penetrating the blood-brain barrier, making it valuable for research applications related to central nervous system infections. -
Bacterial Inhibitor
Bacampicillin is a penicillin antibiotic that serves as a prodrug of ampicillin, designed to enhance oral bioavailability. It exerts its antibacterial activity through the inhibition of cell wall synthesis in susceptible bacteria. This compound is utilized primarily in microbiological research and studies targeting bacterial infections. -
Antibiotic
Norvancomycin hydrochloride is a glycopeptide antibiotic that targets bacterial cell wall synthesis. It demonstrates potent activity against various strains of Staphylococcus aureus and Staphylococcus epidermidis. This compound is primarily utilized in infection research to study antibiotic resistance and the mechanisms of bacterial pathogenicity. -
Antibiotic
4-Aminosalicylic acid hemicalcium acts primarily as an inhibitor of dihydrofolate reductase (DHFR) and serves as an effective antituberculous agent. This compound exhibits notable anti-inflammatory properties, making it a valuable tool for research into inflammatory bowel disease (IBD). Its oral bioavailability enhances its utility in various biochemical and pharmacological studies. -
Cephem Antibiotic
Cefcapene pivoxil is a prodrug form of Cefcapene, functioning as a third-generation cephalosporin antibiotic. It exhibits a broad spectrum of antibacterial activity, making it valuable for in vitro and in vivo studies of bacterial infections. Additionally, Cefcapene pivoxil has potential applications in research related to palmoplantar pustulosis (PPP). -
Antibiotic
Coformycin is a nucleoside antibiotic that primarily inhibits adenosine deaminase (ADA), an enzyme crucial for purine metabolism. This compound exhibits significant anti-tumor and anti-bacterial properties, making it valuable for research in cancer treatment and infectious disease. Coformycin's ability to modulate adenosine levels underscores its potential in therapeutic applications related to cellular proliferation and immune response. -
Antibiotic
L-Amoxicillin is a broad-spectrum antibiotic primarily targeting bacterial cell wall synthesis through inhibition of penicillin-binding proteins. It is widely utilized in clinical settings, often in conjunction with the β-lactamase inhibitor potassium clavulanic acid to enhance antimicrobial efficacy. Rigorous analysis methods for L-Amoxicillin have been developed, adhering to International Conference on Harmonization (ICH) guidelines, ensuring accuracy in quality assessment. Additionally, stability studies and stress testing have been conducted to determine the compound's robustness in various formulations, reinforcing its application in infection management. -
Antibiotic
Fosfomycin is a broad-spectrum antibiotic that irreversibly inhibits MurA, a crucial enzyme in bacterial cell wall synthesis. This compound effectively penetrates the blood-brain barrier and demonstrates significant antimicrobial activity against a variety of bacterial strains, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria. Fosfomycin is widely used in research for studying bacterial resistance mechanisms and developing novel therapeutic strategies. -
Antibiotic
Cefoperazone dihydrate is a semisynthetic cephalosporin antibiotic targeting bacterial cell wall synthesis. It exhibits a broad spectrum of antibacterial activity against various Gram-positive and Gram-negative pathogens. This compound is utilized in microbiological research and clinical settings for the treatment of infections, making it valuable for studies on antibiotic resistance and therapeutic efficacy. -
Antibiotic
Pibrozelesin is a derivative of the antibiotic Duocarmycin B2, primarily targeting DNA cleavage. It demonstrates potent antitumor activity, inhibiting the proliferation of H69 cells with an IC50 of 1.9 μM. Upon activation by carboxyl esterase, Pibrozelesin induces DNA strand breaks, making it a valuable tool for cancer research and the study of DNA damage mechanisms. -
Beta-Lactamase Inhibitor
β-Lactamase-IN-2 is a beta-lactamase inhibitor that targets and inhibits the activity of beta-lactamase enzymes. This compound exhibits significant anti-microbial and anti-bacterial properties, making it useful in overcoming antibiotic resistance. Its application extends to research focused on enhancing the efficacy of beta-lactam antibiotics in clinical settings. -
SARS-CoV PLpro Substrate
Z-Arg-Leu-Arg-Gly-Gly-AMC is a synthetic peptide substrate specifically designed for the SARS-CoV PLpro enzyme. This compound facilitates the study of PLpro's proteolytic activity and its role in viral replication. It serves as a valuable tool for researchers investigating the molecular mechanisms of SARS-CoV and developing potential antiviral strategies. -
SARS-CoV-2 PLpro and Mpro Inhibitor
LY1 is a selective covalent inhibitor targeting the SARS-CoV-2 proteases PLpro and Mpro, demonstrating Kd values of 1.5 μM and 2.3 μM for Mpro C145A and PLpro C111A, respectively. It exhibits potent antiviral activity with IC50 values of 0.12 μM against Mpro and 0.99 μM against PLpro. Additionally, LY1 showcases high selectivity, distinguishing itself from other kinases, human proteases, and metalloenzymes, making it a valuable tool for research into SARS-CoV-2 protease inhibition. -
SARS-CoV-2 Inhibitor
SARS-CoV-2-IN-86 is an inhibitor targeting the methyltransferases nsp14 and nsp16 of SARS-CoV-2. This compound, a derivative of Andrographolide, demonstrates significant antiviral activity with low toxicity, evidenced by a predicted LD50 of 700 mg/kg. It serves as a valuable research tool for studying SARS-CoV-2 replication and may contribute to therapeutic strategies against COVID-19. -
SARS-CoV-2 Main Protease Inhibitor
X77 is a potent non-covalent inhibitor of the SARS-CoV-2 main protease (Mpro), displaying an affinity with a Kd value of 0.057 μM. This compound effectively disrupts the proteolytic activity of Mpro, crucial for viral replication. X77 is primarily utilized in research applications aimed at understanding SARS-CoV-2 biology and developing antiviral therapeutics. -
SARS-CoV 3CLpro Inhibitor
GRL-0496 is a potent inhibitor of SARS-CoV 3CLpro, functioning through targeting the viral protease essential for replication. It demonstrates significant enzyme inhibition with an IC50 of 30 nM and exhibits antiviral activity with an EC50 of 6.9 μM against SARS-CoV. This compound is valuable for research into antiviral therapies and the development of inhibitors aimed at addressing coronavirus infections. -
SARS-CoV-2 3CLpro Inhibitor
CCF0058981 is a noncovalent inhibitor targeting the SARS-CoV-2 3CL protease (3CLpro), with an IC50 of 68 nM. This compound also demonstrates activity against the SARS-CoV-1 3CLpro, exhibiting an IC50 of 19 nM. CCF0058981 shows promising antiviral efficacy and is a valuable tool for research applications focused on COVID-19 and coronavirus protease inhibition. -
SARS-CoV-2 Mpro Inhibitor
TKB245 is a potent inhibitor of the SARS-CoV-2 main protease (Mpro), demonstrating significant efficacy in preventing viral replication. This compound is effective in VeroE6 cells, making it a valuable tool for research on COVID-19 pathogenesis and therapeutics. Its role in protease inhibition provides insight into potential antiviral strategies against SARS-CoV-2. -
SARS-CoV-2 inhibitor
SARS-CoV-2-IN-39 is a SARS-CoV-2 inhibitor that functions by inhibiting the SKP2 protein and stabilizing BECN1. With an EC50 value of 1 μM, this compound demonstrates significant antiviral activity against SARS-CoV-2. It is suitable for research applications focusing on viral pathogenesis and the development of therapeutic strategies targeting coronavirus infections. -
SARS-CoV-2 Mpro Inhibitor
CDD-1845 is a potent non-covalent, non-peptide inhibitor of SARS-CoV-2 main protease (Mpro) with a Ki of 3 nM. This compound effectively inhibits various Mpro variants, including ΔP168, A173V, and ΔP168/A173V. CDD-1845 is intended for research applications focused on SARS-CoV-2 protease inhibition and therapeutic development against COVID-19. -
SARS-CoV-2 Inhibitor
Kobophenol A is an oligomeric stilbene that acts as a SARS-CoV-2 inhibitor by hindering the interaction between the ACE2 receptor and the S1-RBD, exhibiting an IC50 value of 1.81 μM. This compound effectively blocks viral infection in cellular models, with an EC50 of 71.6 μM. Additionally, Kobophenol A demonstrates inhibitory activity against partially purified rat brain protein kinase C (PKC), with an IC50 of 52 µM, making it a valuable tool for studies on viral pathogenesis and enzyme regulation. -
SARS-CoV-2 Inhibitor
PAV-104 is an identified inhibitor of SARS-CoV-2, targeting the nucleocapsid (N) protein. By disrupting the oligomerization of the nucleocapsid, PAV-104 effectively interferes with viral particle assembly, thereby impeding replication at a multiplicity of infection (MOI) of 0.01. This compound is a valuable tool for research into antiviral strategies and the mechanistic understanding of SARS-CoV-2 propagation. -
SARS-CoV-2 Inhibitor
MAT-POS-e194df51-1 is an orally active non-covalent inhibitor of the SARS-CoV-2 main protease (Mpro) with an IC50 of 37 nM. This compound exhibits significant cytotoxicity, demonstrated by EC50 values of 64 nM in A549-ACE2-TMPRSS2 cells and 126 nM in HeLa-ACE2 cells. MAT-POS-e194df51-1 can be utilized in research focusing on antiviral drug development and the pathway exploration of SARS-CoV-2 infection mechanisms.
