Catalog No.
Product Name
Application
Product Information
Citations
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Antibiotic
Berkeleylactone F is an antibiotic macrolide that exhibits activity against certain cancer cell lines. Notably, it demonstrates modest inhibitory effects on CCRF-CEM leukemia cells, making it a valuable compound for research in cancer pharmacology and antibiotic mechanisms. Its unique structure can facilitate studies on antibiotic resistance and cellular response to macrolide treatment. -
Antibiotic/Antimicrobial Peptide
Aurein 3.2 is an antimicrobial peptide that exhibits potent antibiotic activity against a range of bacterial pathogens. In addition to its bactericidal properties, Aurein 3.2 demonstrates anticancer activity, making it a valuable compound for research in both infectious disease and cancer therapeutics. Its unique mechanism of action and dual functionality make it an important tool for exploring therapeutic applications in microbiology and oncology. -
Antitumor Antibiotic
Luzopeptin A is an actinoleukin-like antitumor antibiotic that functions primarily as a bifunctional DNA intercalator. It engages with isolated DNA molecules, inducing unwinding and rewinding processes in superhelical PM2 DNA. Additionally, Luzopeptin A exhibits potent activity against HIV-1 and HIV-2 reverse transcriptases, with IC50 values of 7 nM and 68 nM, respectively. This compound is valuable for research applications in cancer therapy and virology. -
Antibiotic
TAN 420C is an antibiotic exhibiting potent cytotoxic activity specifically targeting lymphocytic leukemia cells. This compound has significant implications for research in cancer treatment and drug development, particularly in exploring therapeutic strategies for hematological malignancies. Its effectiveness in inhibiting the proliferation of leukemia cells makes it a valuable tool for studies focused on leukemia therapies. -
Antibiotic
Parvodicin C2 is a glycopeptide antibiotic that targets bacterial cell wall synthesis. It exhibits significant antibacterial activity against a range of gram-positive bacteria. Due to its mechanism of action, Parvodicin C2 is suitable for research applications focused on antimicrobial susceptibility and the development of new antibiotic therapies. -
Antibiotic
Enduracidin A is a polypeptide antibiotic that primarily targets bacterial cell wall synthesis. Isolated from Streptomyces fungicides, it exhibits significant antimicrobial activity against a range of gram-positive bacteria. This compound is valuable for research applications focused on antibiotic resistance mechanisms and the development of new antibacterial agents. -
Antibiotic
TP-1161 is a novel thiopeptide antibiotic that targets various Gram-positive bacteria, demonstrating strong inhibitory effects with MIC values ranging from 0.25 to 4 μg/mL. This compound is not active against Gram-negative bacteria. TP-1161 serves as a valuable tool for research focused on bacterial infections and the development of new antimicrobial therapies. -
Antitumor Antibiotic
Medermycin is an antitumor antibiotic that primarily exerts its effects through inhibition of various cancer cell lines. It demonstrates potent activity against lymphoma L5178Y progenitor cells and multiple drug-resistant leukemias, with ID50 values of 0.02 μg/mL for L5178Y, 0.006 μg/mL for Adriamycin-resistant cells, and 0.008 μg/mL for Bleomycin-resistant cells, among others. Medermycin is valuable for research applications focused on cancer treatment and the mechanisms of antibiotic resistance. -
Antibacterial Agent
Cefroxadine is an orally active cephalosporin antibiotic that targets bacterial cell wall synthesis. It demonstrates superior antibacterial activity compared to cephalexin against Escherichia coli and Klebsiella pneumoniae, with minimum inhibitory concentration (MIC) values of 3.13 and 1.56 μg/mL, respectively. This compound is suitable for research applications focusing on bacterial infections and antibiotic resistance mechanisms. -
Cephem Antibiotic
Cefcapene is an orally active cephem antibiotic that targets and inactivates chromosome-encoded class C β-lactamases. It exhibits significant antibacterial activity, making it a valuable tool for research focused on antibiotic resistance mechanisms and the efficacy of β-lactam antibiotics. Cefcapene is suitable for studies involving bacterial infections and pharmacological evaluations of antibiotics. -
β-lactam Antibiotic
Piperacillin hydrate is a semisynthetic broad-spectrum β-lactam antibiotic that primarily targets penicillin-binding proteins to exhibit potent bactericidal activity against a range of Gram-negative bacteria and select Gram-positive strains. This compound is frequently utilized in conjunction with β-lactamase inhibitors to enhance its efficacy and overcome resistance mechanisms. Piperacillin hydrate is valuable in various research applications focusing on antimicrobial efficacy and resistance patterns. -
Antibiotic
Kalimantacin A is a potent antibiotic targeting bacterial infections. It demonstrates significant antibacterial activity against a range of Staphylococcus species, including methicillin-resistant Staphylococcus aureus (MRSA). This compound is valuable for research applications focused on antibiotic resistance and the development of new antibacterial agents. -
Antibiotic drug
JH-LPH-33 is a sulfonyl piperazine analog that functions as a potent inhibitor of UDP-2,3-diacylglucosamine pyrophosphate hydrolase (LpxH). It exhibits significant antibiotic activity, demonstrating a minimum inhibitory concentration (MIC) of 0.66 μg/mL. This compound is relevant for research applications focused on bacterial resistance mechanisms and the development of novel antimicrobial therapies. -
Antibacterial peptide
LL-37 GKE is an antibacterial peptide derived from the active domain of LL-37. It exhibits significant antibacterial activity, making it a valuable candidate for research in antibiotic development. LL-37 GKE’s properties offer potential applications in the study of infection control and the enhancement of antimicrobial therapies. -
Antibiotic
Josamycin hydrochloride is an orally active macrolide antibiotic that primarily targets bacterial ribosomes, exhibiting potent antimicrobial activity against a diverse range of pathogens. With a dissociation constant (Kd) of 5.5 nM from the ribosome, it effectively inhibits bacterial protein synthesis. This compound is suitable for research applications related to microbiology and the study of antibiotic resistance mechanisms. -
Antibiotic
Chalcomycin is a macrolide antibiotic that primarily targets gram-positive bacteria, demonstrating potent antimicrobial activity against Staphylococcus aureus and Streptococcus pyogenes. In preclinical studies, Chalcomycin has shown efficacy in protecting mice from infections caused by various staphylococci and streptococci, with a favorable safety profile (LD50 > 2500 mg/kg). This compound is valuable for research in antibiotic resistance and therapeutic applications against bacterial infections. -
Antibiotic
Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar-type H+-ATPases, with an IC50 value of 5 nM. This inhibition disrupts proton gradient formation, leading to membrane potential alterations in target cells. Concanamycin B is widely used in research to study cellular ion homeostasis, lysosomal function, and autophagy processes. -
Antibiotic
Alalevonadifloxacin mesylate is an orally active antibiotic that targets both Gram-positive and Gram-negative bacteria. Its potent antibacterial activity makes it relevant for research into acute bacterial skin and skin structure infections as well as hospital-acquired pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA) and other pathogens. This compound demonstrates promise in addressing difficult-to-treat bacterial infections and contributes to the ongoing exploration of new therapeutic options in infectious disease research. -
Antibiotic
Rabelomycin is an antibiotic that primarily targets gram-positive bacteria, demonstrating significant antimicrobial activity. Additionally, it possesses inhibitory effects against inducible nitric oxide synthase (iNOS), with an IC50 value of 63.9 μM. This compound is valuable for research applications focused on bacterial pathogenesis and the modulation of nitric oxide signaling. -
Antibiotic
Cilastatin ammonium salt is an antibiotic that primarily targets Gram-positive cocci, enhancing the efficacy of various beta-lactam antibiotics. With a half-life of 3-4 hours, it is utilized in research to study bacterial resistance mechanisms and evaluate antibiotic combinations. Its role in preserving the pharmacological activity of beta-lactams makes it essential for investigations in microbiology and infectious disease research. -
Antibiotic
Indanomycin is an antibiotic belonging to the pyrroloketoindane class, characterized by its distinct indane ring structure. It exhibits potent bactericidal activity against Gram-positive bacteria, with minimum inhibitory concentration (MIC) values as low as ≤0.2 μg/mL. This compound is essential for research applications targeting bacterial infections and exploring mechanisms of antibiotic resistance. -
Macrolide Antibiotic
Niddamycin is a macrolide antibiotic that targets the 50S ribosomal subunit, effectively inhibiting bacterial protein synthesis. This compound exhibits significant antibacterial activity against a range of Gram-positive bacteria, making it a valuable tool for research into microbial resistance and antimicrobial efficacy. Its mechanism of action makes it suitable for studies focused on ribosome-targeting antibiotics and their potential therapeutic applications. -
Antibiotic
Cetefloxacin is a broad-spectrum antibacterial antibiotic that targets various bacterial pathogens. It demonstrates effective minimum inhibitory concentrations (MIC) ranging from 0.007 to 8 µg/ml. Research indicates that cetefloxacin exhibits protective effects against key pathogens, including Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae, as evidenced in mouse models. This compound is valuable for studies focusing on antibacterial resistance and therapeutic efficacy. -
Antibiotic
Kijanimicin is an antibiotic derived from the microorganism Actinomadura kijaniata SCC 1256. It exhibits potent antibacterial activity against a range of gram-positive bacteria and is primarily utilized in research focused on antimicrobial efficacy and resistance mechanisms. Kijanimicin's unique structure and mode of action make it an important subject of study in the development of new antibiotic therapies. -
Antibiotic
Albicidin is a peptide antibiotic that exhibits potent activity against a range of both Gram-positive and Gram-negative microorganisms. This compound disrupts bacterial cell function, making it a valuable tool for research applications in microbiology and antibiotic susceptibility testing. Its effectiveness against diverse bacterial strains can aid in the exploration of antibiotic resistance mechanisms and the development of new therapeutic strategies. -
Antibiotic
Thiomarinol A, a potent antibiotic, primarily targets bacterial isoleucyl-tRNA synthetase (IleRS), particularly in methicillin-resistant Staphylococcus aureus (MRSA). This compound, a hybrid of dithiolopyrrolone and marinolic acid, demonstrates significant antimicrobial activity through a dose-dependent inhibition, with a Kiapp value of 19 nM. Thiomarinol A is valuable for research applications focused on antibiotic development and the study of resistant bacterial strains. -
Antibiotic
Platencin is a natural broad-spectrum antibiotic derived from Streptomyces platensis. It primarily targets β-ketoacyl-ACP synthases II and III (FabF and FabH), inhibiting their activity with IC50 values of 1.95 and 3.91 μg/ml, respectively. This compound exhibits potent antibacterial activity against Gram-positive bacteria and is of significant interest for research in antibiotic development and resistance. -
Antibiotic
PD 116779 is an antibiotic that exhibits significant anticancer activity. It demonstrates moderate cytotoxic effects against L1210 lymphocytic leukemia and HCT-8 human colon adenocarcinoma cell lines, with respective IC50 values of 3.55 x 10^-7 M and 4.08 x 10^-7 M. This compound is utilized in research applications focusing on the mechanisms of antibiotic resistance and the exploration of novel cancer therapeutics. -
Antibiotic/Antimicrobial Peptide
Aurein 3.1 is an antibiotic antimicrobial peptide that exhibits notable activity against Gram-positive bacteria. It demonstrates a minimum inhibitory concentration (MIC) of 80 μM against Micrococcus luteus and 50 μM against Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mutans, and Bacillus subtilis. Aurein 3.1 is valuable for research applications focused on combating bacterial infections and studying antimicrobial mechanisms. -
Anti-tumor/bacterial Agent
Napyradiomycin A1 is an enantioselective compound belonging to the napyradiomycin family, characterized by its halogenated structure. This compound exhibits significant anti-tumor and antibacterial activities, making it a valuable tool in cancer research and microbiology. Its efficacy against various tumor cell lines, along with activity against select bacterial strains, positions Napyradiomycin A1 as a promising candidate for further investigation in therapeutic applications. -
Antibiotic
FR 901379 is an echinocandin-type lipopeptide antibiotic that targets fungal cell wall synthesis. Derived from a mutant strain of Coleophoma empetri, this compound exhibits potent antifungal activity against various pathogenic fungi. It is widely utilized in research to study fungal infections and evaluate the effectiveness of antifungal therapies. -
Antibiotic
Chloramphenicol succinate is a prodrug of Chloramphenicol, functioning primarily as an antibiotic. It acts as a competitive substrate and inhibitor of succinate dehydrogenase (SDH), which may contribute to its associated haemotoxicity. This compound is widely utilized in pharmacological research to investigate its antimicrobial properties and to study the mechanisms of SDH inhibition in various biological systems. -
Antibiotic
Espinomycin A2 is a sixteen-membered macrolide antibiotic that primarily targets bacterial ribosomes. This compound exhibits potent activity against Gram-positive bacteria, making it a valuable tool for studying bacterial inhibition and resistance mechanisms. Its efficacy in disrupting protein synthesis positions Espinomycin A2 as a relevant candidate in antibiotic research and development. -
Antibiotic
Kigamicin C is an anti-tumor antibiotic that selectively induces cell death in pancreatic cancer PANC-1 cells under nutrient-limiting conditions. This compound demonstrates notable antimicrobial activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Kigamicin C is a valuable reagent for research applications focused on cancer cell metabolism and antibiotic resistance mechanisms. -
ATPase/Bacterial Inhibitor
Dihydronovobiocin is a bacterial inhibitor that targets ATPase activity by binding to the GyrB subunit of DNA gyrase. This compound is useful for investigating the interactions between coumarin antibiotics, such as Novobiocin, Chlorobiocin, and Coumermycin, and their effects on DNA gyrase function. Dihydronovobiocin also has potential applications in the study of bacterial infections, facilitating research into the mechanisms of antibiotic action and resistance. -
Antibacterial Agent
Sulfaethoxypyridazine is a sulfonamide antibacterial agent that primarily targets bacterial dihydropteroate synthase, inhibiting folate synthesis. This compound exhibits significant antibacterial activity, making it effective for use in veterinary medicine as an additive in feedstuffs. Its application is centered on the prevention and treatment of bacterial infections in livestock, enhancing animal health and productivity. -
Penicillin Antibiotic
Penicillin G is a potent penicillin antibiotic targeting bacterial cell wall synthesis. It exhibits strong antibacterial activity against a wide range of Gram-positive bacteria and Gram-negative cocci. This compound is commonly used in research to study bacterial infections and the mechanisms of antibiotic resistance. -
Antibiotic
Sulbenicillin is an antibiotic with a primary action against bacterial cell wall synthesis. It has demonstrated differential activity against various strains of Pseudomonas aeruginosa, particularly in models of infection in mice. Notably, its efficacy against gentamicin-resistant strains is influenced by the specific resistance profiles of those strains. This compound is valuable in researching antibiotic resistance mechanisms and developing new therapeutic strategies. -
Antibiotic
IT-143B is an antibiotic that exhibits potent antibacterial activity against Micrococcus luteus, demonstrating a minimum inhibitory concentration (MIC) of 6.25 μg/mL. Additionally, IT-143B effectively inhibits the growth of KB cancer cells, with an IC50 value of 1.1 ng/mL. This compound is valuable for research applications in microbiology and cancer studies, providing insights into antibacterial mechanisms and potential therapeutic strategies. -
Antibiotic
6"-Deamino-6"-hydroxyparomomycin I is an aminoglycoside antibiotic targeting bacterial protein synthesis. It exhibits potent activity against both Gram-positive and Gram-negative bacteria, making it a valuable compound for studying bacterial resistance and antibiotic efficacy. Additionally, it serves as a key intermediate in the biosynthetic pathway of paromomycin, facilitating research in antibiotic production and modification. -
Antibiotic
m-Chloramphenicol is an impurity of the antibiotic Chloramphenicol, known for its broad-spectrum antimicrobial activity. It functions as a potent inhibitor of bacterial protein biosynthesis by targeting the 50S ribosomal subunit, disrupting polypeptide synthesis. This compound is valuable in research settings focused on antibiotic resistance mechanisms and bacterial protein synthesis studies. -
Antibiotic, Antitumor
Albofungin is an antibiotic isolated from the culture filtrate of Actinomyces tumemacerans strain INMI.P-42. It demonstrates potent antimicrobial activity against a diverse range of gram-positive bacteria and fungi. Additionally, Albofungin exhibits cytotoxic effects on HeLa cell cultures and shows significant antitumor activity in models such as the EHRLICH ascites tumor in mice, making it a valuable reagent for antibacterial and antineoplastic research applications. -
Lincosamide Antibiotic
Pirlimycin hydrochloride is a lincosamide antibiotic that exerts its antimicrobial effects by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit. It demonstrates significant activity against Gram-positive bacteria, making it a valuable reagent for research focused on bacterial infections and antibiotic resistance mechanisms. Its role in the study of protein synthesis inhibition provides insights into bacterial growth and susceptibility profiles. -
Antibiotic
Aurantimycin A is a depsipeptide antibiotic that targets Gram-positive bacteria, demonstrating potent antimicrobial activity. As a substrate of the LieAB transporter, it facilitates the study of bacterial resistance mechanisms and transporter functions. This compound is valuable for research in antibiotic development and microbial pathogenesis. -
Antibiotic
Angiolam A is an antibiotic derived from Angiococcus disciformis, primarily targeting bacterial cell wall synthesis. It demonstrates significant antibacterial activity against Gram-positive bacteria, making it a valuable tool in research focused on combating bacterial infections and studying antibiotic resistance mechanisms. Its distinctive mode of action contributes to the exploration of novel therapeutic strategies in microbiology. -
Antitumor Antibiotic
Fluopsin C is a copper-containing antibiotic that exhibits potent antitumor activity. It also demonstrates significant antibacterial effects against both Gram-positive and Gram-negative bacteria. This compound is primarily utilized in research applications focused on cancer therapy and the study of bacterial infections, providing valuable insights into antibiotic resistance and therapeutic strategies. -
Antibiotic
Altromycin C is a pluramycin-like antibiotic that exhibits significant antibacterial activity. Structurally distinct from other pluramycin-type antibiotics, Altromycin C offers unique properties that warrant further investigation. Its potent bioactivity makes it a valuable reagent for studying antibiotic mechanisms and developing treatments against bacterial infections. -
Antibiotic
2',3'-Dideoxy-5-iodocytidine is an antibiotic that targets bacterial RNA synthesis. Exhibiting significant activity against Mycobacterium species, this compound is also utilized in gene sequencing applications. Its unique structure facilitates the examination of nucleic acid interactions and the development of antimicrobial strategies. -
Carbapenem Antibiotic
DZ-2640 is an orally active carbapenem antibiotic that functions as a prodrug of DU-6681. DU-6681 demonstrates potent antibacterial activity against a wide range of gram-positive and gram-negative bacteria. This compound is designed for research applications focused on combating bacterial resistance and understanding the mechanisms of antibiotic action. -
Quinolone Antibiotic
Fandofloxacin hydrochloride is an orally active quinolone antibiotic targeting bacterial DNA gyrase, which inhibits bacterial DNA replication. This compound exhibits potent antibacterial activity against a range of gram-positive and gram-negative bacteria. Fandofloxacin hydrochloride is suitable for research related to bacterial infections and the assessment of its embryotoxic and teratogenic effects.
