Catalog No.
Product Name
Application
Product Information
Citations
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Anti-Bacterial Agent
(Rac)-Besifloxacin hydrochloride is a fourth-generation fluoroquinolone antibiotic that acts as a potent inhibitor of DNA gyrase and topoisomerase IV. This compound exhibits broad-spectrum antibacterial activity against both Gram-negative and Gram-positive aerobic and anaerobic bacteria, making it valuable in combating drug resistance. Additionally, (Rac)-Besifloxacin hydrochloride possesses anti-inflammatory properties, and it is relevant in the study of bacterial conjunctivitis. -
Bacterial DNA Gyrase B Inhibitor
DNA Gyrase-IN-2 is a potent inhibitor of bacterial DNA gyrase B, demonstrating IC50 values of 3.29-10.49 µM for Escherichia coli and 4.41-5.61 µM for Mycobacterium tuberculosis. This compound exhibits significant anti-tubercular and antibacterial activity, making it valuable for research focused on bacterial replication and antibiotic development. Its specific targeting of DNA gyrase B positions it as a promising candidate for further investigation in treating bacterial infections. -
HIV/HBV Inhibitor
L-2'-Fd4C is an L-nucleoside analogue that acts as an inhibitor of both human immunodeficiency virus (HIV) and hepatitis B virus (HBV). This compound exhibits potent antiviral activity, making it valuable for research focused on the treatment and understanding of these viral infections. Its unique mechanism of action may provide insights into the development of novel therapeutic strategies against HIV and HBV. -
Antibiotics
4-Demethoxy-7,9-di-epi-daunorubicin is an anthracycline antibiotic that targets DNA by intercalating into the double helix, forming stable complexes with calf thymus DNA. Its primary activity includes the inhibition of prokaryotic nucleic acid polymerases, such as E. coli DNA polymerase I and RNA polymerase. This compound is particularly useful in cancer research and investigations into bacterial infections, providing insights into therapeutic mechanisms and potential treatment strategies. -
Antibacterial Agent
S-MGB-234 is an antibacterial agent that functions as a minor groove binder, specifically targeting the causative agents of Animal African Trypanosomiasis (AAT). This compound demonstrates potent in vitro activity against Trypanosoma congolense and Trypanosoma vivax, the primary pathogens responsible for AAT. Notably, S-MGB-234 exhibits a unique resistance profile, lacking cross-resistance with existing diamidine agents and not utilizing the transporters commonly associated with diamidines. -
Antibacterial Agent
Lavofloxacin lactate is an antibacterial agent that primarily targets DNA gyrase and topoisomerase IV, leading to the inhibition of DNA replication and repair in bacteria. This broad-spectrum antimicrobial compound exhibits potent bactericidal activity against a wide range of bacterial species. Researchers can utilize Lavofloxacin lactate to investigate bacterial resistance mechanisms, including the analysis of resistance genes and mutations. -
Antibiotic
Erythromycin A dihydrate is a macrolide antibiotic that targets the bacterial 50S ribosomal subunit, effectively inhibiting RNA-dependent protein synthesis through the blockage of transpeptidation and translocation reactions. It possesses a broad spectrum of antimicrobial activity and is commonly used in microbiological research. Additionally, Erythromycin A dihydrate has demonstrated antitumor and neuroprotective effects, making it valuable for diverse applications in biological research. -
Antibiotic
Erythromycin stearate is a macrolide antibiotic that targets bacterial 50S ribosomal subunits, leading to the inhibition of RNA-dependent protein synthesis through the blockage of transpeptidation and translocation reactions. It exhibits a broad spectrum of antimicrobial activity against various gram-positive and some gram-negative bacteria. In addition to its antibacterial properties, erythromycin stearate has been investigated for its potential antitumor and neuroprotective effects, making it suitable for diverse research applications in microbiology and cancer studies. -
DENV NS5 RdRp Inhibitor
3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) is a nucleotide analog that serves as a potent inhibitor of DENV NS5 RNA-dependent RNA polymerase (RdRp). Functioning as a chain terminator, it effectively suppresses RNA synthesis, making it a valuable tool in virology research. With an IC50 of 0.02 μM against DENV NS5 RdRp, this compound is crucial for studies focusing on antiviral mechanisms and the development of therapeutic strategies targeting dengue virus infections. -
HIV-1 Inhibitor
SJP-L-5 is an HIV-1 capsid dissociation inhibitor that targets the HIV-1 viral capsid, preventing its normal function. It demonstrates significant inhibitory activity against various HIV-1 strains, with an EC50 ranging from 0.16 to 0.97 μg/mL. By effectively blocking the entry of HIV-1 viral DNA into the nucleus, SJP-L-5 offers valuable potential for applications in HIV-1 infection research and development of antiviral therapies. -
Antibacterial Agent
A-65282 is an antibacterial agent that inhibits P4 DNA unknotting, exhibiting an IC50 value of 8 µg/mL. This compound induces DNA breakage through the action of calf thymus topoisomerase II, making it a valuable tool for studying DNA replication and repair mechanisms. Its targeted enzymatic disruption highlights its potential in antibacterial research contexts. -
Antibiotic
Eponemycin is an antibiotic with significant antitumor properties, targeting cancer cell proliferation. It demonstrates potent cytotoxicity against various cancer cell lines including B16-F10, L1210, P388, and HCT-116, with IC50 values of 0.0017, 0.01, 0.031, and 0.0097 µg/mL, respectively. Additionally, Eponemycin effectively inhibits DNA synthesis in the B16-F10 cell line, exhibiting an IC50 of 0.1 µg/mL, thereby demonstrating its utility in cancer research applications focused on DNA replication and cell viability. -
Antibacterial Agent
Anti-MRSA agent 28 is an antibacterial agent specifically designed to target multidrug-resistant (MDR) gram-positive bacterial strains. With minimum inhibitory concentrations (MICs) ranging from 0.06 to 0.125 μg/mL, it effectively inhibits bacterial growth by targeting DNA polymerase IIIC, demonstrating an IC50 of 3.80 μg/mL. This compound exhibits strong antibacterial activity and has anti-inflammatory properties, making it a valuable tool for research applications related to the treatment of gram-positive infections. -
Antiviral Agent
Antiviral agent 67 (compound PC6) is a potent inhibitor of the dengue virus (DENV) NS5 RNA-dependent RNA polymerase, exhibiting a Ki value of 1.12 nM. It demonstrates significant antiviral activity, making it a valuable tool for research focused on DENV replication and antiviral drug discovery. This compound is suitable for studies aimed at understanding the mechanisms of antiviral action and evaluating potential therapeutic strategies against dengue virus infections. -
Antitumor Antibiotic
2-Hydroxyaclacinomycin A is an anthracycline antibiotic that exerts its antitumor effects through the inhibition of RNA and DNA synthesis. It demonstrates potent cytotoxic activity against leukemia L-1210 cells, with IC50 values of 0.10 μg/mL and 0.95 μg/mL for RNA and DNA synthesis, respectively. This compound is valuable for research focused on cancer therapeutics and the cellular mechanisms of anthracycline antibiotics. -
Antitumor Antibiotic
1-Hydroxyoxaunomycin is an antitumor antibiotic that targets cellular proliferation. It effectively inhibits U210 cell growth, demonstrating IC50 values of 0.0005 μg/mL for cell growth, 1.00 μg/mL for DNA synthesis, and 0.76 μg/mL for RNA synthesis. This compound is primarily utilized in cancer research to explore mechanisms of action related to nucleic acid synthesis and cellular function. -
Antibacterial Agent
DV-7751A is a fluoroquinolone antibiotic that primarily inhibits the supercoiling activity of DNA gyrases. This compound demonstrates significant antimicrobial activity against a range of bacterial strains, including Streptococcus pneumoniae, Streptococcus pyogenes, and Peptostreptococcus species. Additionally, DV-7751A exhibits a rapid bactericidal effect against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, making it a valuable reagent for research in antibacterial therapeutics. -
Antibiotic
Erythromycin glutamate is a macrolide antibiotic that primarily targets bacterial 50S ribosomal subunits, inhibiting RNA-dependent protein synthesis by blocking transpeptidation and translocation reactions. This compound demonstrates a broad spectrum of antimicrobial activity against various bacterial pathogens. In addition to its antibiotic properties, erythromycin glutamate has shown potential antitumor and neuroprotective effects, making it valuable for diverse research applications in microbiology, oncology, and neurobiology. -
AntibioticAgent
GSK299423 is an antibiotic agent primarily targeting DNA gyrase. It exhibits potent inhibition of supercoiling in Staphylococcus aureus with an IC50 of 14 nM and in Escherichia coli with an IC50 of 100 nM. This compound is suitable for research applications focused on antibacterial mechanisms and the evaluation of DNA-targeting therapies. -
Antibiotic
Viquidacin is an antibiotic that primarily targets topoisomerase IV and DNA gyrase. It demonstrates significant antibacterial activity against gram-positive bacteria, particularly Staphylococcus aureus, by inhibiting supercoiling, decatenation, and relaxation processes. Viquidacin also exhibits activity against Escherichia coli and shows a minimum inhibitory concentration (MIC) range of 2-128 mg/L against wild-type and mutant strains of S. aureus, making it a valuable reagent for antibacterial research applications. -
Antibiotic
Erythromycin hydrochloride is a macrolide antibiotic that acts as a protein synthesis inhibitor, targeting bacterial ribosomes. It demonstrates broad-spectrum activity against both Gram-positive and some Gram-negative bacteria, making it effective in treating various bacterial infections, including respiratory and skin infections. Additionally, erythromycin hydrochloride has been implicated in the inhibition of mammalian mRNA splicing, indicating potential roles in research related to gene expression and cellular function. This compound is widely utilized in biomedical research for its antibacterial properties and mechanisms. -
Anti-HIV Agent
3′-Azido-2′,3′-dideoxy-CTP (AZddCTP) is a cytidine analog that serves as an anti-HIV agent by acting as a chain terminator. Incorporated into the nascent DNA strand by HIV reverse transcriptase, AZddCTP halts DNA synthesis due to its lack of a 3'-hydroxyl group, effectively inhibiting viral replication. With IC50 values of 15.6 μM against wild-type HIV and 160.8 μM for AZTR HIV, 3′-Azido-2′,3′-dideoxy-CTP demonstrates significant antiviral activity, making it a valuable tool in HIV research. -
Insecticide/Antibacterial Agent
Satranidazole is an orally active insecticide and antimicrobial agent that primarily targets DNA through the formation of reduced nitro intermediates. By inducing helix instability and strand breakage, it exhibits notable antitrichomonal activity against organisms such as Trichomonas vaginalis and Trichomonas foetus, as well as antiamoebic effects in rodent models of hepatic and caecal amoebiasis. Additionally, Satranidazole has been shown to inhibit the replication of bacteriophage φX174 DNA. This compound is valuable for research exploring caecal amoebiasis, trichomoniasis, and anaerobic bacterial infections. -
Anticancer Agent
Endusamycin is an anticancer agent that inhibits protein and nucleic acid synthesis in Ehrlich ascites carcinoma cells. This selective activity contributes to its efficacy as a potential therapeutic for cancer research, while exhibiting no antibacterial or antifungal effects. Endusamycin is suitable for studies aimed at understanding cancer cell metabolism and the development of new cancer treatment strategies. -
Antibacterial Agent
Vaneprim is an antibacterial agent that exhibits broad-spectrum activity against various bacterial strains. Its mechanism involves the inhibition of bacterial cell wall synthesis, leading to cell lysis and death. This reagent is valuable for research applications involving the study of bacterial resistance mechanisms and the development of new antibacterial therapies. -
Antibacterial Agent
Chinenol A is an antibacterial agent derived from the aerial parts of Helwingia chinensis. It exhibits significant activity against various bacterial strains, including Staphylococcus aureus, Mycobacterium tuberculosis, and Streptococcus pneumoniae. This compound is valuable for research focused on bacterial infections and developing therapeutic strategies against resistant bacterial pathogens. -
Antibacterial Agent
Apigravin is a potent antibacterial agent primarily targeting Gram-positive bacteria. It exhibits significant antibacterial activity against Bacillus subtilis, with a minimum inhibitory concentration (MIC) of 61 μM. This compound is valuable for research applications focused on studying bacterial infections and evaluating potential therapeutic agents against multidrug-resistant strains. -
Macrolide Compound
Sch725674 is a macrolide compound known for its antimicrobial properties, particularly against brewer's yeast and Candida albicans. The compound exhibits minimum inhibitory concentrations (MICs) of 8 μg/ml and 32 μg/ml, respectively. Its biological activity makes it suitable for research applications focused on antifungal mechanisms and the development of new antimicrobial strategies. -
Antibacterial
UCM53 is a potent FtsZ inhibitor with significant antibacterial properties. It effectively inhibits the growth of clinical isolates of antibiotic-resistant Staphylococcus aureus and Enterococcus faecalis. This compound is suitable for research applications involving studies on bacterial cell division and the development of novel antibacterial agents. -
Bacterial Inhibitor
Acorafloxacin hydrochloride is a broad-spectrum fluoroquinolone antibacterial agent that targets bacterial DNA gyrase and topoisomerase IV. It exhibits potent activity against a range of Gram-positive bacteria, with a mean MIC90 value of 0.12 mg/L. This compound is particularly relevant for research on acute bacterial skin infections and community-acquired pneumonia, as well as the investigation of methicillin-resistant Staphylococcus aureus (MRSA) infections. -
Anti-Bacterial Agent
Norchelerythrine is an alkaloid derived from the roots of Zanthoxylum capense, exhibiting significant antibacterial properties. It demonstrates inhibitory activity against a range of bacteria, including Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis, and Escherichia coli, with MIC values exceeding 50 µg/mL. This compound is valuable for research applications focused on evaluating antibacterial mechanisms and developing new therapeutic agents against bacterial infections. -
Antibacterial Agent
Nervogenic acid is an aromatic compound with demonstrated antibacterial properties, isolated from Piper elongatum VAHL. It exhibits significant antibacterial activity, making it a valuable reagent for research in microbiology and the development of antimicrobial therapies. Additionally, nervogenic acid offers antioxidative effects, suggesting its potential applications in studies related to oxidative stress and cellular health. -
Bacterial Inhibitor
Targeting the bacterial sliding clamp peptide 46 is a short peptide designed to inhibit the bacterial sliding clamp (SC). By interfering with SC-dependent DNA synthesis, this peptide serves as a valuable tool for studying bacterial replication mechanisms and developing novel antibacterial strategies. Its application in research underscores its potential utility in exploring bacterial growth and resistance pathways. -
Quinolone Broad-Spectrum Antibacterial Agent
PD 140248 hydrochloride is a quinolone broad-spectrum antibacterial agent that exhibits potent bacteriostatic activity, particularly against Gram-positive bacteria. This compound is valuable for in vitro studies aimed at investigating bacterial susceptibility and the mechanisms of antibacterial resistance. Its efficacy in inhibiting Gram-positive pathogens makes it a useful tool for microbiological research and antibiotic development efforts. -
Antibacterial Agent
Antibacterial agent 97 is a potent antibacterial compound with a primary mechanism of inhibiting bacterial growth. It demonstrates significant antibacterial activity, exhibiting minimum inhibitory concentrations (MIC) of 16 µg/mL against both Escherichia coli and Staphylococcus aureus. This compound is applicable in various research settings focused on understanding bacterial resistance and evaluating new antibacterial therapies. -
Bacterial Metabolite
Herbimycin C is a bacterial metabolite derived from Streptomyces hygroscopicus. It exhibits significant cytotoxicity against HeLa and Ehrlich cells, with IC50 values of 7.3 µg/mL and 1.2 µg/mL, respectively. This compound is primarily utilized in cancer research to investigate its potential therapeutic applications and mechanisms of action against tumor cells. -
Antibacterial
Ocotillone (24S)-20,24-Epoxy-25-hydroxydammaran-3-one) is a triterpenoid compound derived from the fruits of Dysoxylum richii. This compound exhibits significant antibacterial activity against pathogens such as Pseudomonas aeruginosa and Salmonella typhimurium, while demonstrating no hemolytic activity. Ocotillone is valuable for research applications focused on antibacterial drug development and the exploration of natural antimicrobial agents. -
Bacterial Growth Substrate
Di-aspartic acid (Aspartylaspartate) serves as a growth substrate for several bacterial species, including Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens, and Fusobacterium nucleatum. Its ability to support the growth of these bacteria makes it a valuable tool in microbiological research, particularly in studies related to periodontal disease and oral microbiome dynamics. -
Antibacterial Agent
Antibacterial Agent 34 is a potent antibacterial compound that enhances the efficacy of Ceftazidime by significantly reducing its minimum inhibitory concentration (MIC) value. This compound exhibits broad-spectrum antibacterial activity and serves as a valuable tool in research applications focused on overcoming antibiotic resistance and improving antibacterial therapies. Its mechanism of action may provide insights into the synergistic effects of antibiotic combinations in combating infectious diseases. -
Antibacterial
Camaric acid is a natural compound with notable antibacterial activity, isolated from the root of Lantana montevidensis. It demonstrates potential in inhibiting bacterial growth, making it a valuable reagent for research into antimicrobial agents and the development of therapeutic alternatives to conventional antibiotics. This compound can be utilized in various biological assays aimed at exploring its effects on bacterial pathogens. -
Antibacterial Agent
Asperglaucin A is a phthalide-like derivative known for its antibacterial activity. It demonstrates potent efficacy against plant pathogens Pseudomonas syringae pv actinidae (Psa) and Bacillus cereus, with a minimum inhibitory concentration (MIC) of 6.25 μM. This compound is useful in research applications aimed at understanding antibacterial mechanisms and developing novel antimicrobial strategies. -
Bacterial
L-leucyldoxorubicin (Leurubicin) is a potent topoisomerase II inhibitor targeting bacterial cells. This compound exhibits significant antibacterial activity, making it a valuable tool for investigating bacterial infections and developing novel therapeutic strategies. Researchers can leverage its mechanism of action to explore the role of DNA topology in bacterial resistance and susceptibility. -
Antibacterial Agent
Glicophenone is an antibacterial agent that exhibits activity against various strains of Staphylococcus aureus, including MRSA and MSSA, with minimum inhibitory concentrations (MICs) of 32 μg/mL. This compound is useful in research applications focused on combating multidrug-resistant bacterial infections. Its efficacy against both methicillin-resistant and methicillin-sensitive strains makes it a valuable tool for studying bacterial resistance mechanisms. -
Antibacterial Peptide
Eumenitin is an antibacterial peptide targeting bacterial membranes, exhibiting broad-spectrum activity against both Gram-positive and Gram-negative bacteria with minimal hemolytic toxicity. It effectively induces the release of β-hexosaminidase from rat peritoneal mast cells and RBL-2H3 cells. Eumenitin is valuable for research into infectious diseases and the mechanisms of antibacterial action. -
Antibacterial Agent
Isovalerylspiramycin II is an antibacterial agent that exhibits potent activity against a variety of bacterial strains. As a primary component of the multi-component antibiotic Bitespiramycin, it plays a critical role in the study of bacterial infections. This reagent is useful in research applications aimed at understanding antibacterial mechanisms and developing new therapeutic strategies. -
Antibacterial Peptide
Oncocin is an antibacterial peptide belonging to the proline-rich antimicrobial peptide (PrAMP) class. It exhibits potent activity against Gram-negative bacteria, with minimal inhibitory concentrations (MIC) ranging from 0.125 to 8 μg/mL against various strains and clinical isolates of Enterobacteriaceae and non-fermenters. Oncocin targets the substrate-binding domain of the chaperone DnaK, leading to protein misfolding and aggregation, ultimately resulting in bacterial cell death. This mechanism makes Oncocin valuable for research into bacterial resistance and antimicrobial therapies. -
Antibacterial Drug
Xibornol is an antibacterial agent that exhibits potent activity against Gram-positive bacteria, including Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus, as well as Actinomyces israelii and Corynebacterium ulcerans. This compound is especially relevant for applications in oral antisepsis and as an adjunctive treatment for pharyngeal infections caused by these microorganisms. Its effectiveness in targeting harmful bacterial strains makes Xibornol a valuable resource in antibacterial research and therapeutic development. -
Antibacterial Agents
(E)-3,4-Dimethoxychalcone acts as an antibacterial agent through its interaction with microbial cellular mechanisms. This compound exhibits significant antimicrobial and antioxidant properties, making it valuable in research applications focused on infection control and oxidative stress studies. Its isoform status enhances the understanding of structure-activity relationships in antimicrobial development. -
Bacterial Inhibitor
Cephabacin M6 is a 7-methoxydesacetylcephalosporin that acts as a bacterial inhibitor. It is isolated from the culture filtrate of Xanthomonas lactamica and exhibits significant antibacterial activity against various bacterial strains. This compound is useful in microbiological research for studying antibiotic mechanisms and resistance patterns in bacteria. -
Bacterial Inhibitor
Lascufloxacin hydrochloride is a potent antibacterial compound that targets bacterial DNA gyrase and topoisomerase IV, exhibiting broad-spectrum activity against diverse clinical isolates. It demonstrates robust efficacy against Gram-positive bacteria, outperforming other quinolone derivatives. Notably, Lascufloxacin hydrochloride shows incomplete cross-resistance to certain quinolone-resistant strains, making it a valuable candidate for further investigation. Its ability to inhibit both wild-type and mutated target enzymes underscores its potential in tackling resistant bacterial infections in research settings.
