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Biological Activity
G-418 (disulfate) is an aminoglycoside antibiotic similar in structure to gentamicin B1, which blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.
| In vitro (25°C) | DMSO | Insoluble | |
| Water | Warmed: 92 mg/mL (132.81 mM) | ||
| Ethanol | Insoluble | ||
| In vivo | Saline | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.44 mL | 72.18 mL | 144.36 mL |
| 0.5 mM | 2.89 mL | 14.44 mL | 28.87 mL |
| 1 mM | 1.44 mL | 7.22 mL | 14.44 mL |
| 5 mM | 0.29 mL | 1.44 mL | 2.89 mL |
*The above data is based on the productmolecular weight 692.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21002 |
|---|---|
| CAS No. | 108321-42-2 |
| Formula | C20H44N4O18S2 |
| M. Wt | 692.71 |
| Purity | >98% |
| Synonyms | Geneticin sulfate; Antibiotic G-418 sulfate, G418, G 418 |
| SMILES | O=S(O)(O)=O.O[C@@H]([C@@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)N)([H])O[C@]2([H])[C@H](O)C)[C@H]([C@@H](C[C@@H]1N)N)O[C@](OC[C@](C)(O)[C@@H]3NC)([H])[C@@H]3O.O=S(O)(O)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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