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Biological Activity
AFN-1252(Debio 1452) is a potent inhibitor of enoyl-acyl carrier protein reductase (FabI), inhibited all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ??0.12 μg/ml.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.64 mL | 133.18 mL | 266.37 mL |
| 0.5 mM | 5.33 mL | 26.64 mL | 53.27 mL |
| 1 mM | 2.66 mL | 13.32 mL | 26.64 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.33 mL |
*The above data is based on the productmolecular weight 375.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A20981 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 620175-39-5 |
| Formula | C22H21N3O3 |
| M. Wt | 375.42 |
| Purity | >98% |
| Synonyms | API-1252, API1252, API 1252; Debio 1452, Debio1452, Debio-1452, AFN1252, AFN 1252 |
| SMILES | O=C(N(C)CC1=C(C)C2=CC=CC=C2O1)/C=C/C(C=C3CC4)=CNC3=NC4=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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