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Catalog No.
Product Name
Application
Product Information
Citations
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CD4-Targeted HIV Inhibitor
Cyclotriazadisulfonamide (CADA) is a selective inhibitor of HIV entry that targets CD4. It functions by inhibiting the co-translational translocation of human CD4 into the endoplasmic reticulum lumen in a signal peptide-dependent manner. In addition, CADA acts as a Sec61 translocon inhibitor, making it a valuable tool for studying HIV pathogenesis and potential therapeutic strategies against HIV infection. -
HIV-1 Inhibitor
Glycolithocholic acid 3-sulfate is a cholic acid derivative that serves as an effective HIV-1 inhibitor. It demonstrates the ability to inhibit the replication of HIV-1 in vitro, making it a valuable tool for studying HIV infection. Additionally, Glycolithocholic acid 3-sulfate may have relevance in research related to gallbladder disease. -
V-ATPase/HIV-1 Inhibitor
Diphyllin is a potent inhibitor of vacuolar H+-ATPase (V-ATPase) with an IC50 of 17 nM, and also acts as an HIV-1 inhibitor with an IC50 of 0.38 μM. This compound effectively disrupts the acidification of osteoclast lysosomes, leading to significant inhibition of osteoclast-mediated bone resorption while leaving osteoblastic bone formation unaffected. Diphyllin is valuable for investigating bone metabolism-related diseases and exploring therapeutic avenues for conditions characterized by excessive bone resorption. -
HIV Inhibitor
Censavudine is a nucleoside reverse transcriptase inhibitor that exhibits potent antiviral activity against HIV. With EC50 values ranging from 30 nM to 81 nM for HIV-2 and 450 nM to 890 nM for HIV-1, this compound is effective in disrupting viral replication. Additionally, Censavudine possesses a reactive alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), making it a versatile tool for click chemistry applications in drug development and molecular biology research. -
HIV/NRTTI Inhibitor
MK-8527 is an orally active inhibitor of HIV that functions as a nucleoside reverse transcriptase translocation inhibitor (NRTTI). This compound exhibits antiviral activity by impeding reverse transcriptase, an essential enzyme for viral replication. MK-8527 is primarily utilized in research focused on the development of HIV therapeutic strategies and studying mechanisms of resistance in retroviral infections. -
HIV Inhibitor
2',3'-Dideoxyadenosine is an inhibitor of HIV replication that functions by incorporating into viral DNA, thereby terminating chain elongation. This compound exhibits significant antiretroviral activity and is utilized in research to understand mechanisms of HIV infection and the development of therapeutic strategies against the virus. Its efficacy makes it a valuable tool in antiviral studies and drug development pipelines focused on HIV. -
HIV Inhibitor
Zingibroside R1 is a dammarane-type triterpenoid saponin that targets HIV through its inhibitory effects. Isolated from the rhizomes, taproots, and lateral roots of Panax japonicus C. A. Meyer, it demonstrates anti-HIV-1 activity, in addition to notable anti-tumor and anti-angiogenic properties. Zingibroside R1 also inhibits 2-deoxy-D-glucose (2-DG) uptake in EAT cells with an IC50 of 91.3 μM, highlighting its potential for further research in cancer and viral therapies. -
HIV Inhibitor
(R)-Edelfosine, also known as (R)-ET-18-OCH3, is an ether lipid analog that primarily targets HIV through its antiviral properties. This compound exhibits significant anti-HIV activity and demonstrates potential antineoplastic effects. It is commonly utilized in research applications related to antiviral therapies and cancer treatment investigations. -
HIV-1 reverse transcriptase Inhibitor
Ulonivirine is an orally active non-nucleoside inhibitor of HIV-1 reverse transcriptase, targeting the hydrophobic binding pocket adjacent to the enzyme's polymerase active site. It effectively disrupts viral replication, making it a valuable tool for research focused on HIV-1 infection and the mechanisms of antiretroviral resistance. Ulonivirine is suitable for studies aimed at understanding HIV-1 pathogenesis and developing therapeutic interventions. -
HIV-1 Integrase Inhibitor
Bictegravir sodium is a highly potent inhibitor of HIV-1 integrase, demonstrating an IC50 of 7.5 nM. This compound exhibits robust and selective anti-HIV activity while maintaining low cytotoxicity. Bictegravir sodium is primarily utilized in research focused on HIV treatment strategies and the development of antiretroviral therapies. -
HIV-1 Integrase Inhibitor
1-Butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide is a potent inhibitor of HIV-1 integrase, targeting both the 3'-processing and strand transfer stages of the integration process. This compound serves as a valuable tool in HIV-1 research, facilitating the study of viral replication and integration mechanisms. Its effectiveness in inhibiting key steps in the integration pathway makes it an important reagent for investigations related to HIV-1 therapeutic development. -
HIV-1 Inhibitor
BIT-225 is an HIV-1 inhibitor that specifically targets the Vpu protein by blocking its ion channel function. This mechanism effectively inhibits the release of HIV-1, particularly in monocyte-derived macrophages, with an EC50 of 2.25 μM. BIT-225 demonstrates a favorable safety profile, exhibiting minimal cytotoxicity (TC50 of 284 μM). This compound is valuable for research into therapeutic strategies for HIV-1. -
HIV Inhibitor
APOBEC3G-IN-1 is a potent inhibitor of the HIV virus that targets the APOBEC3G enzyme. This compound demonstrates significant activity in inhibiting viral replication, making it a valuable tool in HIV research. Its ability to modulate the immune response against HIV provides insights into viral pathogenesis and potential therapeutic strategies. -
Influenza Virus Inhibitor
Sodium copper chlorophyllin B is a sodium-copper complex of chlorophyll with demonstrated antiviral activity against the Influenza virus, exhibiting IC50 values between 50 to 100 μM. It also shows potential activity against HIV. This compound is primarily utilized in research applications aimed at understanding antiviral mechanisms and developing therapeutic strategies for viral infections. -
HIV-1 Nucleocapsid Protein Inhibitor
Claficapavir is a potent inhibitor of the HIV-1 nucleocapsid protein, specifically designed to interfere with its chaperone functions. With an IC50 of approximately 1 μM and a strong binding affinity (Kd = 20 nM), Claficapavir exhibits significant antiviral activity against HIV-1. This compound serves as a valuable tool for research focused on HIV pathogenesis and therapeutic interventions targeting viral replication. -
HIV-1 inhibitor
HIV-1 inhibitor-6 is a diheteroarylamide-based compound that functions as a potent inhibitor of HIV-1 pre-mRNA alternative splicing. This compound effectively blocks HIV replication and exhibits activity against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC50s of 0.6 μM and 0.9 μM, respectively. Additionally, HIV-1 inhibitor-6 demonstrates inhibitory effects against various HIV strains that are resistant to existing therapies targeting reverse transcriptase, protease, integrase, and CCR5, with EC50s ranging from 0.9 to 1.5 μM. This compound is a valuable tool for researching HIV-1 mechanisms and therapeutic strategies. -
HIV Inhibitor
Decanoyl-RVKR-CMK TFA is a potent inhibitor of HIV-1, specifically targeting the over-expression of the gp160 protein, thereby blocking its processing. This compound demonstrates significant antiviral activity against HIV-1 replication, making it a valuable tool in the study of HIV biology and therapeutic development. Its application includes research focused on the mechanisms of HIV infection and potential therapeutic interventions. -
HIV Inhibitor
Schisantherin D is a dibenzocyclooctadiene lignan that exhibits significant anti-HIV activity with an EC50 of 0.5 μg/mL. This compound selectively inhibits endothelin receptor B (ETBR) and demonstrates hepatoprotective properties. Schisantherin D is valuable for research applications focused on HIV replication and the exploration of liver protective mechanisms. -
HIV/SARS-CoV Inhibitor
2-Hydroxyacetophenone is an inhibitor targeting HIV and SARS-CoV. This compound exhibits significant antiviral activity, making it a valuable tool for research in the development of therapeutic strategies against these viral infections. Additionally, it serves as a versatile building block for synthesis in various chemical applications. -
HIV-1 Inhibitor
Fipravirimat dihydrochloride is a potent inhibitor of HIV-1, demonstrating significant antiviral activity against this virus. This compound is valuable for research applications focused on HIV and AIDS, facilitating studies aimed at understanding viral replication mechanisms and testing therapeutic strategies. Its efficacy makes it a crucial tool for the development of new antiviral treatments. -
HIV Inhibitor
GSK2838232 is an inhibitor of HIV reverse transcriptase, displaying potent activity against a diverse array of HIV-1 isolates. This compound is crucial for studying HIV replication and has applications in antiviral drug development and research focused on HIV resistance mechanisms. Its effectiveness in inhibiting viral replication makes it a valuable tool for understanding the dynamics of HIV infections and testing therapeutic strategies. -
HIV-1 Inhibitor
Ingenol-3-palmitate is an ingenane diterpenoid that functions as a potent inhibitor of HIV-1, demonstrating an IC50 value of 4.1 nM. This compound, derived from the roots of Euphorbia ebracteolata, exhibits significant antiviral activity, making it a valuable tool in HIV research. Its mechanism of action can enhance understanding of viral replication and potential therapeutic strategies against HIV infection. -
HIV Inhibitor
Gomisin M2, a lignan derived from the fruits of Schisandra rubriflora, serves as an effective HIV inhibitor with an EC50 of 2.4 μM. In addition to its anti-HIV properties, Gomisin M2 demonstrates anti-cancer and anti-allergic activities, indicating its multifaceted biological potential. This compound may also offer valuable insights for research related to Alzheimer’s disease. -
HIV Inhibitor
Azulene, a bicyclic hydrocarbon, exhibits potent anti-HIV activity by targeting viral replication mechanisms. Isolated from chamomile oil, it serves as an important scaffold in medicinal chemistry, facilitating the design of new antiviral agents. Its unique structure and biological properties make it a valuable compound in HIV research and therapeutic development. -
Nucleoside Reverse Transcriptase Inhibitor
Rovafovir etalafenamide is a prodrug of the adenosine nucleotide analogue GS-9148, functioning as a nucleoside reverse transcriptase inhibitor (NRTI). It demonstrates significant potency against a range of NRTI-resistant HIV-1 mutations, making it an important tool in HIV research. Its effective anti-HIV-1 activity positions it as a valuable compound for studies aimed at understanding viral resistance mechanisms and the development of therapeutic strategies. -
HIV-1 Inhibitor
BDM-2 is a potent allosteric inhibitor of HIV-1 integrase, specifically targeting the IN-LEDGF interaction. With an IC50 of 47 nM, it exhibits significant anti-retroviral activity and an AC50 for IN multimerization activation of 20 nM. BDM-2 effectively disrupts the binding between the integrase catalytic core domain and the LEDGF/p75 integrase binding domain, with an IC50 of 0.15 μM. This compound demonstrates a high degree of selectivity and a favorable cytotoxicity profile, making it a valuable tool for HIV research. -
HIV-1 Capsid Inhibitor
Lenacapavir sodium is an HIV-1 capsid inhibitor that targets the interaction between capsid hexamers and CA monomers. By disrupting capsid assembly and viral maturation, it inhibits the nuclear translocation of HIV-1 DNA and interferes with CA-mediated protein-protein interactions. Additionally, Lenacapavir sodium reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and diminishes the production of mature HIV-1. This reagent is vital for research focused on HIV-1 infection and explores its effects on various HIV-1 subtypes and clinical isolates. -
Nonnucleoside Reverse Transcriptase Inhibitor
IQP-0528 is a potent nonnucleoside reverse transcriptase inhibitor (NNRTI) that effectively targets HIV-1 and HIV-2. It demonstrates remarkable potency with EC50 values of 0.2 nM for HIV-1 and 100 nM for HIV-2. This compound is primarily utilized in research focused on the development of antiviral therapies and the study of HIV replication mechanisms. -
HIV Inhibitor
Bz-RS-iSer(3-Ph)-OMe is a potent HIV inhibitor that specifically targets viral replication processes. This compound effectively disrupts the replication cycle of HSV with minimal cytotoxicity and inhibits mitotic divisions in Vero cells. Additionally, Bz-RS-iSer(3-Ph)-OMe influences tumor size in M-MSV models and modulates immune responses by inhibiting PHA-induced T lymphocyte proliferation, making it a valuable tool for research in virology and cancer biology. -
HIV-1 RNase H Inhibitor
HIV-1 inhibitor-45 is a potent inhibitor of the HIV-1 RNase H enzyme, demonstrating an IC50 value of 0.067 μM. This compound exhibits significant antiviral activity against HIV-1, making it a valuable tool for studying viral replication and pathogenesis. However, it is characterized by low cell permeability, with an apparent permeability coefficient (Papp) of less than 0.48 × 10−6 cm/s, which may impact its effectiveness in cellular models. -
HIV-1 Reverse Transcriptase Inhibitor/μ-opioid Receptor Agonist
Corydine targets HIV-1 reverse transcriptase and the μ-opioid receptor, acting as an inhibitor with an IC50 of 356.7 μg/mL against the enzyme and an EC50 of 0.51 μM at the receptor. It exhibits antinociceptive effects through the modulation of MOR, effectively reducing acetic acid-induced writhing behavior. Corydine has also demonstrated the ability to inhibit the proliferation of various cancer cells and immune cells, making it a valuable reagent for research into HIV infection, visceral pain, and various cancers including leukemia, melanoma, bladder cancer, and colon adenocarcinoma. -
HIV-1 Capsid Protein Inhibitor
I-XW-053 is a specific inhibitor of the HIV-1 capsid protein, demonstrating antiviral activity by disrupting the interaction at the N-terminal domain interface (NTD-NTD) of the capsid protein. It effectively suppresses the replication of HIV-189BZ167 with an IC50 value of 164.2 μM. This compound serves as a valuable tool for researchers investigating HIV-1 pathogenesis and potential therapeutic approaches targeting viral replication. -
HIV protease Inhibitor
Telinavir is a potent and selective inhibitor of HIV protease. It effectively inhibits various strains of HIV-1, HIV-2, and simian immunodeficiency virus at EC50 values of 26 ng/mL (43 nM). With a high degree of protein binding in human plasma and minimal partitioning into erythrocytes, Telinavir serves as a valuable tool in HIV research and therapeutic development. -
Topo IIKHIV Inhibitor
2,4-Dihydroxypyridine is an effective inhibitor of Topoisomerase IIK HIV, demonstrating a pIC50 of 5.05 against this target. Additionally, it displays antiviral activity against HIV-1 replication with a pIC50 of 4.07. This compound is useful for research into HIV treatment strategies and topoisomerase mechanisms. -
SARS-CoV Inhibitor
SARS-CoV-IN-3 is a potent inhibitor of SARS-CoV replication, demonstrating anti-Coronavirus activity with an EC50 value of 3.6 μM in Vero cells. Additionally, it exhibits antimalarial properties against P. falciparum strains 3D7 and W2, with IC50 values of 11.7 nM and 20.4 nM, respectively. SARS-CoV-IN-3 also effectively mitigates HIV-1-induced cytopathic effects, yielding an EC50 of 10 μM in MT-4 cells. This compound is valuable for research in virology and parasitology. -
HIV-1 Inhibitor
Fipravirimat is a potent inhibitor of HIV-1 replication, targeting the viral protein's function. It exhibits significant antiviral activity, showing efficacy in blocking viral entry and replication. This compound is applicable for research focused on HIV and AIDS, providing valuable insights into therapeutic strategies against these infections. -
SARS-CoV Inhibitor
SARS-CoV-IN-2 is a potent inhibitor of SARS-CoV replication, demonstrating anti-Coronavirus activity with an EC50 of 1.9 μM in Vero cells. Additionally, it exhibits significant inhibition of P. falciparum strains, showing IC50 values of 21.5 nM and 30 nM for the 3D7 and W2 strains, respectively. SARS-CoV-IN-2 also mitigates HIV-1-induced cytopathic effects, with an EC50 of 2.9 μM in MT-4 cells. This compound is valuable for research applications targeting both antiviral and antimalarial activities. -
HIV-1 Inhibitor
NBD-14270 is a potent HIV-1 entry antagonist that specifically targets the gp120 protein of the virus. With an IC50 of 180 nM, it exhibits significant antiviral activity against various HIV-1 Env-pseudotyped virus strains. Additionally, NBD-14270 demonstrates low cytotoxicity, with a CC50 exceeding 100 μM, making it a valuable candidate for research applications in HIV-1 inhibition. -
HIV 1 Inhibitor
HIV-1 inhibitor-8 is a potent oral non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting HIV-1. It demonstrates exceptional antiviral activity across various HIV-1 strains, with an EC50 range of 4.44 to 54.5 nM. Additionally, HIV-1 inhibitor-8 has an IC50 of 0.081 µM against wild-type HIV-1 reverse transcriptase, indicating its potential utility in HIV research and therapeutic applications. -
HIV-1 Reverse Transcriptase Inhibitor
Reverse transcriptase-IN-1 is a potent inhibitor of HIV-1 reverse transcriptase, classified as a diarylbenzopyrimidine (DABP) analogue. It exhibits significant antiviral activity, with effective concentration (EC50) values of 3.4 nM, 4.3 nM, and 3.6 nM against HIV-1 strains IIIB, E138K, and K103N, respectively. Additionally, it demonstrates an inhibitory concentration (IC50) of 13.7 nM on the HIV-1 reverse transcriptase enzyme, making it a valuable tool for research in HIV therapeutic development. -
Non-nucleoside Reverse Transcriptase Inhibitor
Talviraline is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets the HIV-1 reverse transcriptase enzyme, effectively hindering the replication of human immunodeficiency virus type 1 (HIV-1). By binding to a distinct site on the enzyme, Talviraline disrupts the viral replication process. This compound serves as a valuable tool for researching antiviral strategies and assessing the safety and efficacy of potential therapies against HIV-1 infection. -
HIV Inhibitor
3′-Azido-2′,3′-dideoxyuridine is a nucleoside analog primarily targeting human immunodeficiency virus (HIV) replication. It exhibits significant antiviral activity in human peripheral blood mononuclear cells (PBMC) while demonstrating minimal toxicity to human bone marrow cells (BMC). In addition to its role as an HIV inhibitor, 3′-Azido-2′,3′-dideoxyuridine serves as a click chemistry reagent, containing an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. -
HIV Inhibitor
Wilfortrine is a bioactive sesquiterpene alkaloid that serves as an HIV inhibitor through its immunosuppressive properties. This compound demonstrates significant anti-HIV activity, making it valuable for research focused on virology and immunology. Additionally, Wilfortrine has been shown to inhibit leukemia cell growth in murine models, indicating its potential utility in cancer research. -
HIV-1 Inhibitor
Fosdevirine serves as a potent, selective non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting human immunodeficiency virus type 1 (HIV-1). It exhibits low nanomolar activity in vitro and demonstrates efficacy against a diverse range of HIV-1 strains, including those resistant to efavirenz. This characteristic makes Fosdevirine a valuable tool for research focused on HIV-1 replication and resistance mechanisms. -
HIV Inhibitor
HIV-1 inhibitor-48 is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets the reverse transcriptase enzyme of HIV-1. This compound demonstrates significant anti-HIV-1 activity, making it a valuable tool for research focused on viral replication and treatment strategies. Its unique mechanism of action offers potential insights into the development of effective therapies for HIV-1 infections. -
HIV-1 Reverse Transcriptase Inhibitor
Atevirdine is a potent non-nucleoside HIV-1 reverse transcriptase inhibitor that specifically targets the reverse transcriptase enzyme. By inhibiting this enzyme, Atevirdine effectively disrupts viral replication, thereby reducing HIV-1 viral load. This compound is useful in research focused on HIV-1 treatment strategies and the development of antiretroviral therapies. -
HIV-1 Inhibitor
IMB-301 is a selective inhibitor of HIV-1 replication that targets the interaction between human APOBEC3G (hA3G) and viral protein Vif. By disrupting this interaction, IMB-301 prevents Vif-mediated degradation of hA3G, a crucial restriction factor in HIV-1 replication. With an IC50 value of 8.63 µM, IMB-301 effectively inhibits HIV-1 replication in H9 cells, making it a valuable tool for studying HIV-1 biology and developing antiviral strategies. -
HIV-1 RT Inhibitor
Tenofovir diphosphate triethylamine is an inhibitor of HIV-1 reverse transcriptase, exhibiting a Ki value of 1.55 μM for DNA and 0.022 μM for RNA. This antiretroviral compound is a valuable tool in the study of HIV replication and resistance, facilitating research into the mechanisms of AIDS pathology and treatment strategies. Its potent inhibitory activity supports the development of therapeutic approaches aimed at curbing HIV infection. -
HIV-1 Inhibitor
AzddMeC is a potent, selective nucleoside analogue that functions as an inhibitor of HIV-1 reverse transcriptase, effectively blocking HIV-1 replication. The compound demonstrates strong antiviral activity, with EC50 values of 9 nM in HIV-1-infected human peripheral blood mononuclear cells and 6 nM in HIV-1-infected human macrophages. In addition to its antiviral properties, AzddMeC serves as a versatile click chemistry reagent, containing an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne- and DBCO- or BCN-containing molecules, respectively, making it a valuable tool in chemical biology research. -
HIV Inhibitor
Pentosan Polysulfate is an orally bioavailable sulfonated polysaccharide that acts as an HIV inhibitor by interfering with viral attachment to host cells. Its potent and selective anti-HIV activity positions it as a valuable compound for HIV research. Additionally, Pentosan Polysulfate possesses anti-inflammatory and pro-chondrogenic properties, making it relevant for studies related to interstitial cystitis.
