HIV-1 inhibitor-45 is a potent inhibitor of the HIV-1 RNase H enzyme, demonstrating an IC50 value of 0.067 μM. This compound exhibits significant antiviral activity against HIV-1, making it a valuable tool for studying viral replication and pathogenesis. However, it is characterized by low cell permeability, with an apparent permeability coefficient (Papp) of less than 0.48 × 10−6 cm/s, which may impact its effectiveness in cellular models.
HIV-1 inhibitor-45 is a potent inhibitor of the HIV-1 RNase H enzyme, demonstrating an IC50 value of 0.067 μM. This compound exhibits significant antiviral activity against HIV-1, making it a valuable tool for studying viral replication and pathogenesis. However, it is characterized by low cell permeability, with an apparent permeability coefficient (Papp) of less than 0.48 × 10−6 cm/s, which may impact its effectiveness in cellular models.
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