Lenacapavir sodium is an HIV-1 capsid inhibitor that targets the interaction between capsid hexamers and CA monomers. By disrupting capsid assembly and viral maturation, it inhibits the nuclear translocation of HIV-1 DNA and interferes with CA-mediated protein-protein interactions. Additionally, Lenacapavir sodium reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and diminishes the production of mature HIV-1. This reagent is vital for research focused on HIV-1 infection and explores its effects on various HIV-1 subtypes and clinical isolates.
Lenacapavir sodium is an HIV-1 capsid inhibitor that targets the interaction between capsid hexamers and CA monomers. By disrupting capsid assembly and viral maturation, it inhibits the nuclear translocation of HIV-1 DNA and interferes with CA-mediated protein-protein interactions. Additionally, Lenacapavir sodium reduces the formation of 2-LTR circles and pre-integration proviruses, induces aberrant capsids, and diminishes the production of mature HIV-1. This reagent is vital for research focused on HIV-1 infection and explores its effects on various HIV-1 subtypes and clinical isolates.
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