IMB-301 is a selective inhibitor of HIV-1 replication that targets the interaction between human APOBEC3G (hA3G) and viral protein Vif. By disrupting this interaction, IMB-301 prevents Vif-mediated degradation of hA3G, a crucial restriction factor in HIV-1 replication. With an IC50 value of 8.63 µM, IMB-301 effectively inhibits HIV-1 replication in H9 cells, making it a valuable tool for studying HIV-1 biology and developing antiviral strategies.
IMB-301 is a selective inhibitor of HIV-1 replication that targets the interaction between human APOBEC3G (hA3G) and viral protein Vif. By disrupting this interaction, IMB-301 prevents Vif-mediated degradation of hA3G, a crucial restriction factor in HIV-1 replication. With an IC50 value of 8.63 µM, IMB-301 effectively inhibits HIV-1 replication in H9 cells, making it a valuable tool for studying HIV-1 biology and developing antiviral strategies.
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