Reverse transcriptase-IN-1 is a potent inhibitor of HIV-1 reverse transcriptase, classified as a diarylbenzopyrimidine (DABP) analogue. It exhibits significant antiviral activity, with effective concentration (EC50) values of 3.4 nM, 4.3 nM, and 3.6 nM against HIV-1 strains IIIB, E138K, and K103N, respectively. Additionally, it demonstrates an inhibitory concentration (IC50) of 13.7 nM on the HIV-1 reverse transcriptase enzyme, making it a valuable tool for research in HIV therapeutic development.
Reverse transcriptase-IN-1 is a potent inhibitor of HIV-1 reverse transcriptase, classified as a diarylbenzopyrimidine (DABP) analogue. It exhibits significant antiviral activity, with effective concentration (EC50) values of 3.4 nM, 4.3 nM, and 3.6 nM against HIV-1 strains IIIB, E138K, and K103N, respectively. Additionally, it demonstrates an inhibitory concentration (IC50) of 13.7 nM on the HIV-1 reverse transcriptase enzyme, making it a valuable tool for research in HIV therapeutic development.
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