Diacetylcercosporin is a perylenequinone produced by the fungi Cercospora and Septoria, primarily targeting parasites. It demonstrates potent inhibitory activity against Plasmodium falciparum, with IC50 values of 2.75 μM for the D6 clone and 1.94 μM for the W2 strain, as well as against Leishmania donovani at an IC50 of 3.1 μM. Additionally, Diacetylcercosporin exhibits significant cytotoxic effects on various human cancer cell lines, including SK-MEL, KB, BT549, and SKOV3, with IC50 values ranging from 4.8 to 8.7 μM. This reagent also acts as a phytotoxin, inhibiting the growth of crops such as lettuce and bentgrass at a concentration of 1.62 mM.
Diacetylcercosporin is a perylenequinone produced by the fungi Cercospora and Septoria, primarily targeting parasites. It demonstrates potent inhibitory activity against Plasmodium falciparum, with IC50 values of 2.75 μM for the D6 clone and 1.94 μM for the W2 strain, as well as against Leishmania donovani at an IC50 of 3.1 μM. Additionally, Diacetylcercosporin exhibits significant cytotoxic effects on various human cancer cell lines, including SK-MEL, KB, BT549, and SKOV3, with IC50 values ranging from 4.8 to 8.7 μM. This reagent also acts as a phytotoxin, inhibiting the growth of crops such as lettuce and bentgrass at a concentration of 1.62 mM.
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