(Rac)-ACT-451840 is a parasite inhibitor with significant antimalarial properties. It demonstrates effective antimalarial activity against P. berghei-infected mice, achieving an ED90 of 13 mg/kg and showing inhibitory effects at higher doses. In humanized immunodeficient mouse models infected with P. falciparum, the compound has an ED90 of 3.7 mg/kg. (Rac)-ACT-451840 is structurally similar to artemisinin and offers a rapid onset of action, although it necessitates repeated high dosing for optimal efficacy.
(Rac)-ACT-451840 is a parasite inhibitor with significant antimalarial properties. It demonstrates effective antimalarial activity against P. berghei-infected mice, achieving an ED90 of 13 mg/kg and showing inhibitory effects at higher doses. In humanized immunodeficient mouse models infected with P. falciparum, the compound has an ED90 of 3.7 mg/kg. (Rac)-ACT-451840 is structurally similar to artemisinin and offers a rapid onset of action, although it necessitates repeated high dosing for optimal efficacy.
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