Dieugenol is a neolignan with notable antiprotozoal activity, specifically targeting parasitic infections. It exhibits inhibitory effects on T. cruzi, exhibiting IC50 values of 15.1 μM against amastigotes and 11.5 μM against trypomastigotes, while demonstrating antioxidative properties by scavenging superoxide anions and inhibiting thiobarbituric acid reactive substances (TBARS) formation. Although Dieugenol disrupts the plasma membrane integrity of T. cruzi trypomastigotes at a concentration of 15 μM, it shows cytotoxicity to NCTC L-929 fibroblasts with a CC50 value of 58.2 μM, indicating its potential for further investigation in parasitic disease research.
Dieugenol is a neolignan with notable antiprotozoal activity, specifically targeting parasitic infections. It exhibits inhibitory effects on T. cruzi, exhibiting IC50 values of 15.1 μM against amastigotes and 11.5 μM against trypomastigotes, while demonstrating antioxidative properties by scavenging superoxide anions and inhibiting thiobarbituric acid reactive substances (TBARS) formation. Although Dieugenol disrupts the plasma membrane integrity of T. cruzi trypomastigotes at a concentration of 15 μM, it shows cytotoxicity to NCTC L-929 fibroblasts with a CC50 value of 58.2 μM, indicating its potential for further investigation in parasitic disease research.
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