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Biological Activity
Lumefantrine, also known as HSDB 7210, is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas.
| In vitro | DMSO | 11 mg/mL (20.79 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.91 mL | 94.53 mL | 189.06 mL |
| 0.5 mM | 3.78 mL | 18.91 mL | 37.81 mL |
| 1 mM | 1.89 mL | 9.45 mL | 18.91 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.78 mL |
*The above data is based on the productmolecular weight 528.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A17309 |
|---|---|
| CAS No. | 82186-77-4 |
| Formula | C30H32Cl3NO |
| M. Wt | 528.94 |
| Purity | >98% |
| Synonyms | HSDB 7210; HSDB7210; HSDB-7210; Lumefantrine; Benflumetol. |
| SMILES | CCCCN(CCCC)CC(C1=C2C3=C(C=C(C=C3)Cl)C(=CC4=CC=C(C=C4)Cl)C2=CC(=C1)Cl)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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