Catalog No.
Product Name
Application
Product Information
Citations
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AChE Inhibitor
Arisugacin B is a selective acetylcholinesterase (AChE) inhibitor with potent oral bioactivity. Its mechanism of action involves the inhibition of AChE, which plays a crucial role in neurotransmission by regulating acetylcholine levels. This compound is useful in research applications focused on neurodegeneration and related disorders, offering insights into potential therapeutic strategies for conditions such as Alzheimer's disease. -
Stable Isotope
(Rac)-Rivastigmine-d6 is a stable isotope-labeled form of Rivastigmine, a potent inhibitor of cholinesterases, specifically butyrylcholinesterase (BChE) and acetylcholinesterase (AChE), with IC50 values of 0.037 μM and 4.15 μM, respectively. This compound effectively crosses the blood-brain barrier, making it a valuable tool for investigating cholinergic mechanisms.(Rac)-Rivastigmine-d6 is primarily utilized in research focused on mild to moderate Alzheimer's dementia and dementia associated with Parkinson's disease, facilitating studies on neurotransmission and therapeutic interventions. -
AChE Inhibitor
AE027 is a potent inhibitor of acetylcholinesterase (AChE), effectively targeting both wild-type and the resistant F348Y mutation, with IC50 values of 10 μM and 43 μM, respectively. This compound exhibits significant biological activity in blocking AChE, making it a valuable tool for research in neurodegenerative disorders and studies related to cholinergic signaling. AE027 provides potential insights into therapeutic strategies for conditions associated with AChE dysregulation. -
AChE Inhibitor
Undulatine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 7.4 μM. This compound is capable of crossing the blood-brain barrier through passive permeation, making it a valuable tool for investigating the pathophysiology of Alzheimer's disease. Its ability to modulate cholinergic activity positions Undulatine as a promising candidate for research into therapeutic strategies for neurodegenerative disorders. -
AChE Inhibitor
N-Methylcalycinine is a natural product that acts as an acetylcholinesterase (AChE) inhibitor. Isolated from the roots of Stephania epigaea, it possesses potential therapeutic implications in various research fields, including asthma, cancer, dysentery, fever, hyperglycemia, intestinal disorders, inflammation, sleep disturbances, and tuberculosis. This compound may be valuable for studies exploring its effects on neurotransmitter regulation and related biological processes. -
Acetylcholinesterase Inhibitor
Samioside is an acetylcholinesterase inhibitor primarily extracted from the plants Phlomis nissolii and P. capitata. It exhibits notable free-radical scavenging and antimicrobial properties, making it a valuable compound for biological research. Samioside is particularly relevant for studies investigating its potential anti-Alzheimer’s effects, offering insights into therapeutic avenues for neurodegenerative conditions. -
Cholinesterase (ChE) Activator
FK960 is a cholinesterase activator with potential applications in anti-dementia therapy. It enhances cholinergic neurotransmission, effectively reversing the reduction in cerebral blood flow (rCBF) induced by sensory stimulation. In macaque studies, FK960 has demonstrated the ability to restore rCBF responses that were eliminated by treatment with physostigmine, lasting for up to one hour. Notably, FK960 does not restore rCBF responses affected by NMDA modulators, suggesting a targeted mechanism independent of non-glutamatergic pathways. -
α7 nAChR Agonist
WAY-361789 is an orally active agonist of the α7 nicotinic acetylcholine receptor (α7 nAChR), with an EC50 of 0.18 μM. This compound enhances cognitive function and shows promise in addressing cognitive deficits associated with Alzheimer's Disease and schizophrenia. It serves as a valuable tool for researchers investigating the role of α7 nAChR in neurodegenerative conditions and psychiatric disorders. -
AChE Inhibitor
Buxbodine B is an acetylcholinesterase (AChE) inhibitor with an IC50 of 50 μM. It demonstrates significant potential in the study of neurodegenerative diseases, particularly Alzheimer's disease, by modulating cholinergic transmission. Its inhibitory action on AChE facilitates the exploration of therapeutic strategies aimed at enhancing cognitive function and memory retention in affected populations. -
AChE Inhibitor
Arisugacin D is an acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 value of 3.5 μM. This compound is notable for its potential to enhance synaptic acetylcholine levels, making it useful in studies related to neurodegenerative diseases such as Alzheimer's. The inhibition of AChE facilitates the investigation of cholinergic signaling pathways and the development of therapeutic strategies targeting cognitive decline. -
AChE1 Inhibitor
AL284 is a potent inhibitor of Anopheles gambiae acetylcholinesterase 1 (AgAChE1), targeting key residues Tyr489Ag and Trp441Ag within the enzyme structure. This compound demonstrates significant biological activity in disrupting neurotransmitter breakdown, which is critical for the survival of disease-transmitting mosquitoes. AL284 is valuable for research applications focused on controlling mosquito populations and studying vector-borne diseases. -
Cholinesterase Inhibitor
Neostigmine hydroxide is a potent cholinesterase inhibitor that enhances acetylcholine levels at neuromuscular junctions. This compound is primarily utilized in research related to myasthenia gravis and other neuromuscular disorders, aiding in the exploration of muscular function and neuropharmacology. Its ability to counteract muscle weakness makes it a valuable tool for studying therapeutic interventions in cholinergic signaling. -
AChE Inhibitor
Coroxon, an AChE inhibitor, is an oxidative metabolite of the organophosphate insecticide Coumaphos. This compound exhibits significant insecticidal and acaricidal activity, making it valuable for pest control research. Additionally, Coroxon can be hydrolyzed by phosphotriesterases from microorganisms such as Nocardia asteroides, resulting in the production of the fluorescent compound Chlorferon, which can be utilized in biochemical assays and studies related to enzyme activity. -
Microbial Metabolite
Arisugacin G, a microbial metabolite, acts as a structural analog of Arisugacin A. This compound demonstrates significant potential in research applications related to microbial biochemistry and the study of analogs in biological systems. Notably, Arisugacin G lacks activity against acetylcholinesterase (AChE), making it a candidate for investigations where AChE inhibition is not desired. -
AChE Inhibitor
Salvianolic acid H is a potent inhibitor of acetylcholinesterase (AChE), serving to enhance cholinergic neurotransmission. Its primary biological activity includes the potential modulation of neurodegenerative processes associated with cognitive decline. This compound is valuable for research applications aimed at understanding Alzheimer's disease and other conditions linked to cholinergic deficits. -
Cholinesterase (ChE) Antagonist
Pipenzolate bromide is a muscarinic receptor antagonist that functions by inhibiting cholinesterase (ChE) activity, thereby preventing the binding of acetylcholine to its receptors. This compound exhibits significant anticholinergic properties, making it valuable in pharmacological research related to disorders such as motion sickness, asthma, and gastrointestinal motility. Pipenzolate bromide serves as a useful reagent in studies aimed at understanding the modulation of cholinergic signaling pathways. -
hAChE Inhibitor
7-Methoxytacrine is a potent inhibitor of human acetylcholinesterase (hAChE) with an IC50 value of 10 μM. This compound is utilized in research related to Alzheimer's disease, highlighting its potential role in modulating neurotransmitter levels and improving cognitive function. Its mechanism of action makes it a valuable tool for investigating therapeutic strategies in neurodegenerative disorders. -
Insecticide
Demeton-S is an organophosphate insecticide that primarily targets butyrylcholinesterase and acetylcholinesterase enzymes. By inhibiting these enzymes, Demeton-S disrupts cholinergic neurotransmission, leading to paralysis and mortality in insects. This compound is utilized in agricultural research and pest management studies to evaluate insect resistance and to develop sustainable control strategies. -
ChE Activator
HP 184 is an acetylcholine release stimulator, functioning as a cholinesterase (ChE) activator. This compound enhances synaptic transmission by promoting the release of acetylcholine, making it valuable for studies in neurobiology and neuromuscular disorders. Additionally, the compound's ADME properties can be modified by substituting hydrogen with deuterium, allowing for further exploration of its pharmacokinetics and pharmacodynamics in research applications. -
Microbial Metabolite
Arisugacin E is a microbial metabolite with a structural similarity to Arisugacin A. This compound has been characterized for its unique biological properties but does not exhibit activity against acetylcholinesterase (AChE). Arisugacin E may serve as a useful tool for studying microbial metabolites and their role in biochemical pathways within various research applications. -
ChE Inhibitor
Lycodine is a lycopodium alkaloid that acts as a cholinesterase inhibitor. It demonstrates significant anticholinesterase activity, making it a valuable tool for research into neurological disorders and cognitive function. Its potential applications extend to studying mechanisms of acetylcholine modulation and developing therapeutic approaches for conditions such as Alzheimer’s disease. -
AChE Inhibitor
Graphislactone A is an acetylcholinesterase (AChE) inhibitor, which demonstrates significant potential in the investigation of neurodegenerative diseases. With an IC50 value of 27 μM, it effectively inhibits AChE activity, contributing to enhanced cholinergic signaling. Additionally, Graphislactone A exhibits antioxidant properties, making it a valuable compound for research focused on oxidative stress-related disorders. -
Cholinesterase (ChE) Inhibitor
Echinenone acts as an acetylcholinesterase (AChE) inhibitor, exhibiting an IC50 value of 16.29 μg/mL. This compound demonstrates anti-Aβ(25-35) activity and has been shown to decrease malondialdehyde (MDA) levels while enhancing the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). These properties indicate its potential use in research focused on neuroprotection and alleviating oxidative stress-related damage. -
Microbial Metabolite
Arisugacin H is a microbial metabolite that functions as a structural analog of Arisugacin A. This compound exhibits notable biological activity, primarily contributing to the study of microbial interactions and metabolites. Although it has been characterized, it does not demonstrate inhibition of acetylcholinesterase (AChE), making it a useful tool for exploring alternative pathways in microbial research. -
AChE Inhibitor
Isodimethoate is an acetylcholinesterase (AChE) inhibitor that demonstrates potent anticholinesterase activity. As a thermal decomposition product of Dimethoate, it effectively inhibits AChE in human red blood cells, making it valuable for studying cholinergic signaling and related neurochemical pathways. This compound is frequently utilized in research focused on neurotoxicology and the effects of organophosphates on enzymatic activity. -
Organophosphorus Insecticide
Heterophos is an organophosphorus insecticide that functions as an acetylcholinesterase (AChE) inhibitor. By disrupting the normal breakdown of acetylcholine, Heterophos leads to the accumulation of this neurotransmitter, resulting in disturbances of nerve conduction in insects. This mechanism underpins its efficacy in pest control applications, particularly in the study of insect neurophysiology and insecticide resistance mechanisms. -
Natural Product
Dihydrokaempferol-3-O-β-D-glucoside is a natural product that acts as an inhibitor of acetylcholinesterase (AChE). Isolated from the bark of Cudrania tricuspidata, this compound demonstrates potential biological activity in modulating cholinergic signaling. Its research applications include studies on neurodegenerative diseases and exploration of cognitive enhancement mechanisms. -
AChE Inhibitor
Galactamine is an acetylcholinesterase (AChE) inhibitor that plays a crucial role in modulating neurotransmitter levels by preventing the breakdown of acetylcholine. This compound is primarily utilized in research investigating Alzheimer's disease and other neurodegenerative disorders, where it helps to elucidate the mechanisms underlying cognitive decline and potential therapeutic strategies. Galactamine's ability to enhance cholinergic signaling makes it a valuable tool in the study of efficacy and safety in neuropharmacology. -
hBuChE Inhibitor
Deoxynojirimycin tetrabenzyl ether is an inhibitor of human butyrylcholinesterase (hBuChE), with an IC50 value of 2.0 μM. This compound is utilized in research focused on neurological disorders and cholinergic system regulation, making it valuable for studies involving enzyme inhibition and potential therapeutic applications in cognitive decline. -
Stable Isotope
Acephate-d6 is a deuterium-labeled derivative of Acephate, a widely used anticholinesterase insecticide. It functions by inhibiting acetylcholinesterase (AChE) activity in insects, leading to disruption of their nervous system and effective pest control. This stable isotope variant is useful for research applications involving metabolic studies, pesticide residue analysis, and environmental monitoring in agricultural and horticultural settings. -
Microbial Metabolite
Arisugacin F is a microbial metabolite that serves as a structural analog of Arisugacin A. This compound is primarily investigated for its role in various biological pathways, although it has been reported to exhibit no activity against acetylcholinesterase (AChE). Arisugacin F may be utilized in research exploring microbial metabolism and the structural influences of similar compounds on biological systems. -
Insecticide
Quintiofos is an insecticide that functions by inhibiting the enzyme acetylcholinesterase in insects, leading to disruptions in nerve conduction. This mechanism results in effective insecticidal activity against a variety of pests, including aphids, whiteflies, and stem borers. Quintiofos is a valuable tool for researchers studying insect physiology and pest management strategies. -
AChE Inhibitor
Arisugacin C is an acetylcholinesterase (AChE) inhibitor exhibiting an IC50 of 2.5 μM, demonstrating its potent activity in modulating cholinergic neurotransmission. This compound is valuable for research into neurodegenerative diseases, including Alzheimer’s disease, where AChE inhibition may alleviate cognitive decline. Its selectivity and efficacy make it a useful tool in studying the mechanisms of cholinergic signaling and developing potential therapeutic strategies. -
Monoamine Oxidase Inhibitor
4-Chlorochalcone is a selective monoamine oxidase inhibitor, demonstrating an IC50 of 0.082 μM against hMAO-B and 9.95 μM against hMAO-A. This compound also shows inhibitory activity towards acetylcholinesterase, with an IC50 of 2.79 μM. As a chalcone derivative, 4-Chlorochalcone is valuable for research focused on neurodegenerative diseases and the modulation of neurotransmitter levels. -
Cholinesterase (ChE) Inhibitor
AChE-IN-83 is a potent acetylcholinesterase (AChE) inhibitor targeting cholinesterases in various biological systems. This compound effectively inhibits the growth and behavior of Aphelenchoides oryzae, a nematode pathogen in rice, demonstrating an LC50 value of 19.0 μg/mL over 48 hours. AChE-IN-83 disrupts the nematode cuticle, promoting the accumulation of reactive oxygen species, lipofuscin, and lipids, thereby offering applications in nematode management and enhancing rice seed health. -
ChE Inhibtior
(S)-Ladostigil is a cholinesterase (ChE) inhibitor known for its neuroprotective properties. While it exhibits limited inhibition of monoamine oxidase B (MAO-B), its primary mechanism enhances cholinergic neurotransmission, making it of interest in the study of neurodegenerative disorders. This compound is utilized in research focusing on Alzheimer's disease and other conditions where cholinergic dysfunction is implicated. -
Cholinesterase Inhibitor
Mobam is a cholinesterase inhibitor with significant efficacy against Anoplura Pediculidae. This compound effectively reduces cholinesterase (ChE) levels in plasma, erythrocytes, and brain tissue of rat models, leading to suppressed avoidance behavior. Mobam is primarily utilized in toxicological research and studies focused on neurological effects and insecticidal applications. -
Stable Isotope
Donepezil-d7 is a deuterium-labeled analog of Donepezil, a selective and potent inhibitor of acetylcholinesterase (AChE). This compound demonstrates impressive inhibitory activity with IC50 values of 8.12 nM for bovine AChE and 11.6 nM for human AChE, making it a valuable tool for studying cholinergic signaling and Alzheimer's disease. Researchers can utilize Donepezil-d7 in pharmacokinetic studies and metabolic profiling to better understand the compound's activity and metabolism in various biological contexts. -
Cholinesterase (ChE) Inhibitor
SZ1676 is a cholinesterase (ChE) inhibitor that functions primarily by blocking the enzymatic activity of acetylcholinesterase. This compound demonstrates significant potential in studying neuromuscular transmission and related disorders. Its biological activity may support research in pharmacology and toxicology, particularly concerning neuromuscular blocking agents and their therapeutic implications. -
Glucosylceramide Synthase Inhibitor
Glucosylceramide synthase-IN-6 is a selective inhibitor of glucosylceramide synthase (GCS), targeting the enzymatic pathway involved in the synthesis of glucosylceramide. This compound is valuable for investigating the role of GCS in various diseases, particularly lysosomal storage disorders. Its application in research facilitates a better understanding of GCS activity and its implications in cellular metabolism and pathology. -
Glucosylceramide Synthase Inhibitor
Glucosylceramide synthase-IN-5 is a potent inhibitor of glucosylceramide synthase (GCS). This compound is instrumental in the exploration of diseases and disorders linked to GCS activity, particularly lysosomal storage disorders. Its ability to modulate GCS activity makes it a valuable tool in biochemical research aimed at understanding sphingolipid metabolism and related pathologies. -
Glucosylceramide Synthase Inhibitor
Lucerastat is a potent inhibitor of glucosylceramide synthase (GCS), specifically in its galactose form derived from Miglustat. This compound exhibits significant biological activity in modulating glycosphingolipid metabolism and has potential applications in the investigation of Fabry disease. Researchers may employ Lucerastat to explore therapeutic avenues and understand the pathophysiology associated with GCS-related disorders. -
GCS/GBA2 Inhibitor
Sinbaglustat is a dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2). This N-alkyl iminosugar is orally bioavailable and capable of penetrating the blood-brain barrier, making it a valuable tool for investigating central neurodegenerative disorders linked to lysosomal dysfunction. Its unique properties facilitate research into potential therapeutic strategies for conditions such as Gaucher disease and other lysosomal storage disorders. -
Glucosylceramide Synthase Inhibitor
Ibiglustat (L-Malic acid) is a potent inhibitor of glucosylceramide synthase (GCS), demonstrating oral bioavailability and the ability to penetrate the blood-brain barrier. This compound is instrumental for research into various lysosomal storage disorders, including Gaucher disease type 3, Parkinson's disease linked to GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease. Its selective inhibition of GCS makes it a valuable tool for studying the biochemical pathways associated with these conditions. -
GCS Inhibitor
TP-060 is a glucosylceramide synthase (GCS) inhibitor, exhibiting potent inhibitory activity with IC50 values of 31 nM for human GCS and 51 nM for mouse GCS. This compound is orally active and capable of penetrating the blood-brain barrier, making it a valuable tool for investigating GCS-related pathways. TP-060 is particularly relevant for research into Gaucher's disease and other conditions associated with GCS dysregulation. -
GCS Inhibitor
D-threo-PDMP hydrochloride is a potent inhibitor of glucoceramide synthase (GCS), effectively reducing glycosphingolipids such as GM3 and GD3 on the cell surface. This compound impairs glycosylation processes, leading to reduced axonal growth and branching, as well as decreased adhesion of B16 melanoma cells, effectively mimicking the effects of hyperglycemia and TGF-β1. Additionally, D-threo-PDMP hydrochloride protects hepatocytes from TNF-α-induced apoptosis by inhibiting GD3 synthesis. This reagent is valuable for research into diseases associated with glycosphingolipid metabolism. -
Glucosylceramide Synthase Inhibitor
Ibiglustat succinate is a potent glucosylceramide synthase (GCS) inhibitor with oral bioavailability and the ability to penetrate the blood-brain barrier. This compound is primarily used in research focused on Gaucher disease type 3, Parkinson's disease linked to GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease. Its inhibitory action on GCS has potential implications for understanding and treating these neurodegenerative and lysosomal storage disorders. -
PDMP Erythro Isomer
D,L-erythro-PDMP hydrochloride is an inhibitor of UDP-glucose:ceramide glucosyltransferase, exerting its effects through the targeting of glycosphingolipid biosynthesis. This compound demonstrates significant growth inhibition of cultured rabbit skin fibroblasts, making it a valuable tool for studying sphingolipid metabolism and its implications in cellular growth and differentiation. D,L-erythro-PDMP hydrochloride is useful in research related to cancer, neurodegenerative diseases, and other conditions where glycosphingolipid metabolism is altered. -
GCS Inhibitor
Glucosylceramide synthase-IN-2 is a potent, orally bioavailable inhibitor of glucosylceramide synthase (GCS), demonstrating IC50 values of 15 nM for human GCS and 190 nM for mouse GCS. This compound functions as a noncompetitive inhibitor in the presence of C8-ceramide and UDP-glucose. Glucosylceramide synthase-IN-2 is particularly useful for research into Gaucher's disease, offering valuable insights into the modulation of glycosphingolipid metabolism. -
GlcCer Synthase Inhibitor
D-threo-PPMP hydrochloride is a potent inhibitor of glucosylceramide (GlcCer) synthase, effectively disrupting the synthesis of glucosylceramide. This compound has been shown to block karyokinesis and reduce cyst production, making it a valuable tool for studying lipid metabolism and related pathophysiological conditions. Its application extends to research on lysosomal storage disorders and other diseases associated with glycolipid accumulation.
