Fig. 1 · Structure
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FK960
Cholinesterase (ChE) Activator
FK960 is a cholinesterase activator with potential applications in anti-dementia therapy. It enhances cholinergic neurotransmission, effectively reversing the reduction in cerebral blood flow (rCBF) induced by sensory stimulation. In macaque studies, FK960 has demonstrated the ability to restore rCBF responses that were eliminated by treatment with physostigmine, lasting for up to one hour. Notably, FK960 does not restore rCBF responses affected by NMDA modulators, suggesting a targeted mechanism independent of non-glutamatergic pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 133920-70-4 |
| Applications | Cholinesterase (ChE) Activator |
| Formula | C13H16FN3O2 |
| Molecular Weight | 265.28 |
| SMILES | O=C(C1=CC=C(C=C1)F)NN2CCN(CC2)C(C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.