Catalog No.
Product Name
Application
Product Information
Citations
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Muscarinic Antagonist
ASP9133 is a long-acting muscarinic antagonist that effectively inhibits bronchoconstriction. This compound is primarily researched for its potential applications in the treatment of chronic obstructive pulmonary disease (COPD), providing insights into the management of airway obstruction and related respiratory disorders. Its mechanism of action makes it a valuable reagent for studies focusing on respiratory physiology and pharmacology. -
mAChR Antagonist
Eucatropine is a potent antagonist of muscarinic acetylcholine receptors (mAChRs) with an IC50 value of 0.583 μM. This anticholinergic agent is effective in modulating acetylcholine signaling pathways, making it valuable for research applications in neuropharmacology and studies related to cholinergic system modulation. Its specificity for mAChRs allows for potential insights into the therapeutic effects and mechanisms underlying various neurological disorders. -
mAChR4 Allosteric Modulator
VU6009048 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (mAChR4) that exhibits effective central nervous system penetration. This compound is useful for investigating neurological disorders such as Parkinson's disease, Huntington's disease, and schizophrenia, facilitating the exploration of therapeutic options targeting cholinergic signaling pathways. Its mechanism of action enhances receptor activity, making it a valuable tool for research in neuropharmacology. -
mAChR Inhibitor
Phenglutarimid hydrochloride is identified as a muscarinic acetylcholine receptor (mAChR) inhibitor. This compound exhibits anticholinergic properties and is primarily utilized in research related to Parkinson's disease and other neurological disorders. Its ability to modulate cholinergic signaling makes it a valuable tool for investigating therapeutic approaches for movement disorders and cognitive function. -
Muscarinic M2 Receptor Antagonist
SCH 57790 is a selective antagonist of the muscarinic M2 receptor, promoting enhanced acetylcholine release that can lead to improved cognitive performance. This compound has demonstrated efficacy in reversing memory deficits induced by Scopolamine in murine models, showcasing its potential in cognitive enhancement research. Notably, SCH 57790 exhibits a favorable toxicity profile at doses up to 100 mg/kg. -
Anticholinergic/ Antiparkinsonian Agent
Metixene is an anticholinergic and antiparkinsonian agent that primarily targets muscarinic receptors. It exerts its activity by potently inhibiting the binding of quinuclidinyl benzilate (QNB), with IC50 and Ki values of 55 nM and 15 nM, respectively. Metixene is utilized in research related to Parkinson's disease for understanding its mechanisms and potential therapeutic effects. -
Muscarinic Agonist
SR-46559A is a potent muscarinic agonist, primarily targeting muscarinic acetylcholine receptors. This compound has demonstrated key biological activity in modulating neurotransmission and is particularly useful in research focused on social olfactory recognition and related neurobiological pathways. SR-46559A offers valuable insights into the role of cholinergic signaling in olfactory processing and social behavior studies. -
Anticholinergic/Antispasmodic Agent
Octamylamine acts primarily as an anticholinergic agent by inhibiting acetylcholine receptors, thereby reducing involuntary muscle contractions. This compound exhibits significant antispasmodic activity, making it useful in the study of gastrointestinal disorders and conditions characterized by smooth muscle spasms. Its role in neuromuscular research further highlights its potential applications in pharmacological testing and therapeutic development. -
mAChR Agonist
RS-86 is a potent and selective agonist of muscarinic acetylcholine receptors (mAChRs). This compound elicits cholinergic excitatory effects, including smooth muscle contraction, ganglion depolarization, and central hypothermia. RS-86 is utilized in research focused on the pathophysiology of Alzheimer's disease and the underlying mechanisms of cholinergic signaling. -
M1/M3 Muscarinic Receptors Agonist
L 689660 maleate is a selective agonist for M1 and M3 muscarinic receptors, exhibiting potent cholinomimetic activity. Specifically, it demonstrates full agonist properties at the M1 muscarinic receptor in the rat superior cervical ganglion with a pEC50 of 7.3. Additionally, L 689660 maleate effectively activates M3 receptors in the guinea pig ileum myenteric plexus-longitudinal muscle and trachea, with pEC50 values of 7.5 and 7.7, respectively. This compound is valuable for research applications targeting muscarinic receptor signaling pathways. -
mAChR Agonist
Oxotremorine is a potent agonist of muscarinic acetylcholine receptors (mAChRs), specifically targeting the M1 and M3 subtypes. This compound demonstrates nicotine-like effects, making it valuable for research related to cholinergic signaling and neuropharmacology. Its unique pharmacological profile supports investigations into cognitive function, memory enhancement, and the role of acetylcholine in various neurological disorders. -
mAChR Modulator
VU0029767 is an allosteric enhancer of the M1 muscarinic acetylcholine receptor (mAChR). It modulates M1 receptor activity by increasing agonist affinity, thereby enhancing receptor function. This compound displays unique properties in various experimental conditions, including interactions with mutant M1 receptors and differential effects on downstream signaling pathways. VU0029767 is valuable for research applications involving receptor pharmacology and neuropharmacology. -
Anticholinergic/Antispasmodic Agent
Octamylamine hydrochloride is recognized as an anticholinergic and antispasmodic agent. It functions by inhibiting cholinergic activity, thereby providing relief from smooth muscle spasms. This compound is utilized in various research applications, particularly in studies focusing on gastrointestinal motility and related disorders. Its mechanism of action makes it a valuable tool in the exploration of antispasmodic therapies and neurological research. -
mAChR inhibitor
Heliosupine N-oxide is a potent inhibitor of muscarinic acetylcholine receptors (mAChR), exhibiting an IC50 value of 350 μM. As a metabolite of Heliosupine and classified as a pyrrolizidine alkaloid, Heliosupine N-oxide serves as a valuable tool for research into cholinergic signaling pathways and related neurological studies. Its inhibitory properties can aid in elucidating the role of mAChR in various physiological and pathological processes. -
Muscarinic M1-4 Receptor Antagonist
Diphenidol is a non-selective antagonist of muscarinic M1-M4 receptors, exhibiting anti-arrhythmic properties. Additionally, it acts as a potent inhibitor of voltage-gated ion channels, including sodium, potassium, and calcium channels, in neuronal cells. This compound is valuable for research in the mechanisms of antivertigo and antinausea treatments. -
Stable Isotope
Fesoterodine-d3 is a deuterium-labeled derivative of Fesoterodine, functioning as a competitive antagonist of muscarinic acetylcholine receptors (mAChRs). It exhibits non-subtype selective activity, with pKi values of 8.0, 7.7, 7.4, 7.3, and 7.5 for M1, M2, M3, M4, and M5 receptors, respectively. This reagent is primarily utilized in research related to overactive bladder (OAB) and studies involving receptor pharmacology. Its stable isotope form aids in biochemical assays and metabolic studies. -
mAChR Antagonist
Dexetimide hydrochloride is a muscarinic acetylcholine receptor (mAChR) antagonist that effectively mitigates neuroleptic-induced Parkinson's syndrome. This compound is utilized primarily to alleviate movement disorders associated with neuroleptic treatment. As a selective inhibitor of cholinergic receptors, Dexetimide hydrochloride provides insights into cholinergic system modulation, making it a valuable tool for research in neuropharmacology and movement disorder therapies. -
mAChR Agonist
(±)-Muscarine chloride is an agonist of muscarinic acetylcholine receptors (mAChRs). As a prototype compound, it exhibits key biological activity by mimicking the action of acetylcholine, leading to varied physiological responses. This reagent is useful for research applications exploring mAChR signaling pathways, neurobiology, and the modulation of cholinergic activity. -
Cardiac Muscarinic Receptor Antagonist
Propylbenzilylcholine mustard is a selective, irreversible antagonist targeting cardiac muscarinic receptors in rats. It covalently modifies these receptors in a dose- and time-dependent manner, demonstrating stability across various ionic strengths and GTP-containing buffers. This reagent is valuable for investigating the structure and function of cardiac muscarinic receptors, particularly their heterogeneity and implications in cardiovascular pharmacology. -
Imidafenacin Metabolite
Imidafenacin Metabolite M4 is a key metabolite of the muscarinic acetylcholine receptor antagonist Imidafenacin. This compound retains biological activity that may contribute to the pharmacological effects observed with the parent drug. It serves as a valuable tool for investigating the metabolism and pharmacokinetics of muscarinic antagonists in various research applications. -
Muscarinic Agonist
A-72055 is a partial agonist of muscarinic receptors, specifically targeting M1 and M2 subtypes with Ki values of 32 nM and 30 nM, respectively. This compound enhances cognitive function and has potential applications in addressing learning and memory deficits. A-72055 is valuable for research focused on neurological disorders, particularly those associated with cognitive impairment. -
M1 Receptor Agonist
YM-796 dihydroxybutanedioate is a selective agonist of the muscarinic M1 receptor. It has demonstrated potential in enhancing cognitive function and reducing amyloid plaque accumulation, making it relevant in the study of cognitive impairment diseases, particularly Alzheimer’s disease. This compound serves as a valuable tool for researchers investigating therapeutic strategies for cognitive deficits associated with neurodegenerative disorders. -
M 2 Antagonist
AQ-RA 741 is a potent and selective M2 antagonist that effectively inhibits vagally or agonist-induced bradycardia in various animal models, including rats, cats, and guinea pigs. This compound is valuable in the study of bradycardic disorders, providing insights into potential therapeutic strategies for managing heart rate irregularities. Its specificity towards the M2 muscarinic receptor makes it a critical tool for investigating cholinergic signaling pathways in cardiovascular research. -
mAChR Inhibitor
Phenglutarimid is a muscarinic acetylcholine receptor (mAChR) inhibitor that exhibits anticholinergic properties. It is primarily utilized in research related to Parkinson's disease and other cholinergic dysfunctions. Its ability to modulate neurotransmitter activity makes it a valuable tool for investigating the therapeutic mechanisms underlying movement disorders. -
Muscarinic M4/M1/M2 Agonist
M1/M2/M4 Muscarinic Agonist 1 is a selective agonist targeting muscarinic M4, M1, and M2 receptors, with EC50 values of 6.5 nM, 26 nM, and 210 nM, respectively. This compound facilitates receptor activation, making it valuable in studying cholinergic signaling and its implications in neurological conditions. Research applications include investigations into mental disorders such as schizophrenia and delusions, providing insights into therapeutic approaches for these conditions. -
Ammonium Derivate With Anticholinergic Activity
Methantheline bromide is a quaternary ammonium derivative that exhibits anticholinergic activity. It is known to significantly reduce axillary sweat production, making it useful in studies related to hyperhidrosis. Additionally, Methantheline bromide serves as a valuable tool in research investigating intractable peptic ulcers, contributing to the understanding of gastrointestinal disorders. -
M3/M5 mAChR PAM
M3 mAChR agonist 1 is a positive allosteric modulator (PAM) specifically targeting the M3 and M5 muscarinic acetylcholine receptors. This compound exhibits notable selectivity over other muscarinic subtypes, including M1, M2, and M4. M3 mAChR agonist 1 enhances the contraction of isolated rat bladder strips by modulating M3 receptor activity, thus promoting signaling pathways associated with bladder function. This reagent is suitable for research applications in endocrinology and related fields. -
M1-Selective PAM
PF-06827443 is a selective positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor. This compound exhibits high potency and oral bioavailability while effectively penetrating the central nervous system. PF-06827443 has been shown to enhance cholinergic signaling, leading to cholinergic adverse effects and convulsions. It is a valuable tool for researchers investigating M1 receptor functions and their roles in neurological conditions. -
mAChR Modulator
VU0090157 is a positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR). By binding to an allosteric site, VU0090157 enhances the affinity of acetylcholine, thereby influencing neurotransmission. This compound is valuable for research in neuropsychiatric disorders such as schizophrenia and Alzheimer's disease, facilitating the exploration of therapeutic strategies that target mAChRs. -
M2/M3 Antagonist
PSD-506 is a muscarinic M2/M3 antagonist that effectively inhibits the activity of these receptors. This compound demonstrates notable potential in researching bladder overactivity and urinary incontinence. Its specific targeting of M2 and M3 receptors makes PSD-506 a valuable tool for studying related therapeutic avenues and advancing understanding of related physiological mechanisms. -
mAChR Antagonist
Butropium bromide is a competitive antagonist of muscarinic acetylcholine receptors (mAChRs). It effectively inhibits acetylcholine-induced glandular secretion and smooth muscle contraction, thereby reducing salivary gland secretion and alleviating respiratory smooth muscle spasms. This compound is valuable for studying conditions related to excessive salivation and could aid in research on respiratory function modulation. -
Muscarinic Receptor Blocker
Ethybenztropine hydrochloride is a potent muscarinic receptor blocker with established anticholinergic properties. This compound demonstrates significant antiparkinsonian activity, effectively improving motor symptoms in patients with Parkinson's disease. Additionally, Ethybenztropine hydrochloride may exhibit dopamine reuptake inhibitory effects, contributing to its therapeutic efficacy. It is utilized in research applications focused on neuropharmacology and the modulation of neurotransmitter balance. -
M1/M3 Receptor Inhibitor
Imidafenacin hydrochloride is an orally active inhibitor of muscarinic M1 and M3 receptors. It effectively inhibits bladder contraction in vivo, demonstrating significant antidiuretic effects through the enhancement of vasopressin signaling. This compound is particularly relevant for research focused on overactive bladder and related conditions, making it a valuable tool in the study of urinary disorders. -
M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator
PF-06764427 is a selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor. It demonstrates significant agonist activity at the M1 receptor, enhancing cholinergic signaling. This compound is valuable for research applications pertaining to Alzheimer's disease and schizophrenia, providing insights into cognitive function and neuropharmacology. -
Muscarinic-3 Agonist
Methacholine bromide is a potent agonist of the muscarinic-3 (M3) receptor. Its primary action induces bronchoconstriction by directly stimulating acetylcholine receptors on smooth muscle, resulting in airway narrowing. This compound is particularly sensitive for identifying bronchial hyperresponsiveness (BHR) and is utilized in clinical settings to assess airway hyperresponsiveness (AHR) in patients presenting with asthma-like symptoms, especially those with normal resting expiratory flow rates. -
mAChR Agonist
Betovumeline is a selective agonist for muscarinic acetylcholine receptors (mAChRs). This compound plays a key role in modulating cholinergic signaling and demonstrates potential biological activity in various neurological disorders. It is widely utilized in research applications focused on understanding the mechanisms underlying cognitive function and neurodegenerative diseases. -
M1 mAChR Antagonist
VU0455691 is a selective orthosteric antagonist of the M1 muscarinic acetylcholine receptor (mAChR) with a pIC50 of 6.64 and an IC50 of 0.23 µM for human M1. This compound is useful in investigating the physiological and pathological roles of M1 mAChR in various neurological disorders. Its ability to selectively inhibit M1 mAChR activation makes it a valuable tool for research into cholinergic signaling pathways and potential therapeutic interventions. -
Anticholinergic Agent
Mazaticol is an anticholinergic agent targeting muscarinic acetylcholine receptors. It effectively blocks cholinergic nerve activity and serves as a potent inhibitor of 3H-QNB and 3H-PZ binding, demonstrating high affinity for M2 receptors. Additionally, Mazaticol exhibits inhibitory effects on dopamine uptake in striatal nerve terminals, making it valuable for research into parkinsonian syndromes. -
mAChR Antagonist
UH-AH 37 is a selective antagonist of muscarinic acetylcholine receptors (mAChR). It demonstrates enhanced potency in inhibiting muscarinic responses in intestinal tissue compared to cardiac tissue. This compound is valuable for research into gastrointestinal motility disorders and the pharmacological modulation of mAChR signaling pathways. -
M4 Modulator
VU6008677 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor, with an EC50 value of 120 nM for hM4. This compound enhances receptor activity and is valuable for studying M4 receptor functions and related signaling pathways. Additionally, VU6008677 demonstrates inhibition of cytochrome P450 and possesses favorable pharmacokinetic properties in rat models, making it suitable for in vivo research applications. -
Bronchospasmolytic Agent
Flutropium bromide is a potent bronchospasmolytic agent that exerts its effects through anticholinergic action. It is effective in suppressing bronchospasms and is primarily utilized in research related to asthma and chronic obstructive pulmonary disease (COPD). This compound provides valuable insights into respiratory mechanisms and potential therapeutic interventions for obstructive airway disorders. -
Presynaptic Cholinergic Modulator
SM-21 maleate serves as a presynaptic cholinergic modulator and binds to central muscarinic receptors with an affinity of 0.174 μM. This compound exhibits significant biological activity related to cholinergic signaling, making it a valuable tool for studying synaptic transmission and neuropharmacology. Its application in research may provide insights into cholinergic dysfunctions and potential therapeutic targets for neurological disorders. -
mAChR Inhibitor
Cyclobuxine D is a steroidal alkaloid that functions as a muscarinic acetylcholine receptor (mAChR) inhibitor. It exhibits a notable bradycardic effect in rat models and effectively inhibits contractions induced by acetylcholine and Ba++ in isolated rabbit jejunum muscle. Due to its biological activities, Cyclobuxine D is valuable for research in pharmacology and cardiovascular studies. -
Stable Isotope
Tolterodine-d14 hydrochloride is a deuterium-labeled version of Tolterodine hydrochloride, a potent muscarinic acetylcholine receptor (mAChR) inhibitor. This compound competitively binds to acetylcholine, thereby reducing involuntary bladder muscle contractions and modulating sympathetic nervous activity. In addition to its role in managing overactive bladder and urinary tract infections, Tolterodine has been shown to restore the Nrf2/NF-κB signaling pathway, offering protective effects against inflammation and ferroptosis. Its applications extend to studies involving reactive oxygen species and lipid oxidation. -
Muscarinic M1 Receptor Agonist
Muscarinic M1 receptor agonist-1 is a selective agonist targeting the muscarinic M1 receptor. This compound plays a significant role in modulating neurotransmission and is of particular interest in the study of psychiatric disorders, including schizophrenia. Its ability to activate the M1 receptor may provide insights into therapeutic strategies for managing cognitive dysfunction associated with these conditions. -
Sigma 1 Recognition Site Ligand
RLH-033 is a potent and selective ligand for the sigma 1 recognition site. It exhibits high affinity for sigma 1 sites labeled by [3H](+)-pentazocine, demonstrating a Ki value of 50 pM. This compound is valuable for research applications targeting sigma 1 receptor functions, contributing to the understanding of its roles in neuroprotection and various pathophysiological conditions. -
mAChR Antagonist
AQ-RA 721 is a selective muscarinic acetylcholine receptor (mAChR) antagonist that exhibits a differential affinity for the M2 and M4 receptor subtypes. This compound is valuable for studying muscarinic receptor diversity and function, facilitating research into receptor pharmacology and potential therapeutic applications. It can be employed in investigations into central nervous system activities and cardiovascular regulation, contributing to a better understanding of muscarinic signaling pathways. -
M1 Receptor Partial Agonist
Sabcomeline is a selective partial agonist of the muscarinic M1 receptor, known for its ability to enhance cognitive function. This compound holds promise for research applications related to Alzheimer's disease, where modulation of the M1 receptor may assist in ameliorating cognitive deficits. Its functional selectivity makes Sabcomeline a valuable tool for investigating the role of muscarinic receptors in neurodegenerative disorders. -
M1 Cholinergic Agonist
Trans-Cevimeline hydrochloride is a selective M1 cholinergic agonist, known for its potential in modulating cholinergic neurotransmission. This compound exhibits significant biological activity relevant to neurodegenerative conditions, particularly Alzheimer's disease. Researchers can utilize trans-Cevimeline hydrochloride to investigate its effects on cognitive function and cholinergic signaling pathways. -
M3 Muscarinic Receptor Antagonist
AE9C90CB is a selective antagonist of the M3 muscarinic receptor, exhibiting a high affinity with a pKi value of 9.90. This compound is 20-fold more selective for M3 compared to the M2 muscarinic receptor, making it a valuable tool for studying M3 receptor-mediated signaling pathways. AE9C90CB is suitable for research applications investigating the role of M3 muscarinic receptors in various physiological and pathological processes.
