Propylbenzilylcholine mustard

Catalog No.: A61475
Cardiac Muscarinic Receptor Antagonist
Propylbenzilylcholine mustard is a selective, irreversible antagonist targeting cardiac muscarinic receptors in rats. It covalently modifies these receptors in a dose- and time-dependent manner, demonstrating stability across various ionic strengths and GTP-containing buffers. This reagent is valuable for investigating the structure and function of cardiac muscarinic receptors, particularly their heterogeneity and implications in cardiovascular pharmacology.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPropylbenzilylcholine mustard is a selective, irreversible antagonist targeting cardiac muscarinic receptors in rats. It covalently modifies these receptors in a dose- and time-dependent manner, demonstrating stability across various ionic strengths and GTP-containing buffers. This reagent is valuable for investigating the structure and function of cardiac muscarinic receptors, particularly their heterogeneity and implications in cardiovascular pharmacology.
Product Information
Catalog NumA61475
FormulaC21H26ClNO3
Molecular Weight375.89
CAS Number36167-80-3
SMILESO=C(C(C1=CC=CC=C1)(C2=CC=CC=C2)O)OCCN(CCC)CCCl
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