VU6009048

Catalog No.: A61457
mAChR4 Allosteric Modulator
VU6009048 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (mAChR4) that exhibits effective central nervous system penetration. This compound is useful for investigating neurological disorders such as Parkinson's disease, Huntington's disease, and schizophrenia, facilitating the exploration of therapeutic options targeting cholinergic signaling pathways. Its mechanism of action enhances receptor activity, making it a valuable tool for research in neuropharmacology.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionVU6009048 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (mAChR4) that exhibits effective central nervous system penetration. This compound is useful for investigating neurological disorders such as Parkinson's disease, Huntington's disease, and schizophrenia, facilitating the exploration of therapeutic options targeting cholinergic signaling pathways. Its mechanism of action enhances receptor activity, making it a valuable tool for research in neuropharmacology.
Product Information
Catalog NumA61457
FormulaC16H17N3S
Molecular Weight283.39
CAS Number2226116-93-2
SMILESN=1C=CC2=C(SC3=NC(=CC(=C32)C)C)C1NC4CCC4
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