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PF-06764427

M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator

PF-06764427 is a selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor. It demonstrates significant agonist activity at the M1 receptor, enhancing cholinergic signaling. This compound is valuable for research applications pertaining to Alzheimer's disease and schizophrenia, providing insights into cognitive function and neuropharmacology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	1842371-08-7
Applications	M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator
Formula	C₂₄H₂₅N₅O₃
Molecular Weight	431.49
SMILES	O=C(C1=CN(CC2=CC=C(C3=NN(C)C=C3)C=C2)C4=CC=CN=C41)N[C@@H]5[C@@H](O)COCC5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.