Fig. 1 · Structure
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Methacholine bromide
Muscarinic-3 Agonist
Methacholine bromide is a potent agonist of the muscarinic-3 (M3) receptor. Its primary action induces bronchoconstriction by directly stimulating acetylcholine receptors on smooth muscle, resulting in airway narrowing. This compound is particularly sensitive for identifying bronchial hyperresponsiveness (BHR) and is utilized in clinical settings to assess airway hyperresponsiveness (AHR) in patients presenting with asthma-like symptoms, especially those with normal resting expiratory flow rates.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 333-31-3 |
| Applications | Muscarinic-3 Agonist |
| Formula | C8H18BrNO2 |
| Molecular Weight | 240.14 |
| Synonyms | Acetyl-β-methylcholine bromide |
| SMILES | CC(OC(C)=O)C[N+](C)(C)C.[Br-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.