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PF-06827443

M1-Selective PAM

PF-06827443 is a selective positive allosteric modulator (PAM) of the M1 muscarinic acetylcholine receptor. This compound exhibits high potency and oral bioavailability while effectively penetrating the central nervous system. PF-06827443 has been shown to enhance cholinergic signaling, leading to cholinergic adverse effects and convulsions. It is a valuable tool for researchers investigating M1 receptor functions and their roles in neurological conditions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	2115022-67-6
Applications	M1-Selective PAM
Formula	C₂₄H₂₄N₂O₄
Molecular Weight	404.46
SMILES	O=C1C2=CC(CC3=CC=C(C4=COC=N4)C=C3)=C(C)C=C2CN1[C@@H]5[C@H](COCC5)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.