Other inhibitors

BTZ043 (BTZ038, BTZ044) inhibits decaprenylphosphoryl-β-d-ribose 2?-epimerase, which is an enzyme which produces the cell wall of the pathogenic bacterium Mycobacterium tuberculosis.

Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure.

Busulfan is a cell cycle non-specific alkylating antineoplastic agent, in the class of alkyl sulfonates.

Butylscopolamine BR is an orally available bromide salt form of butylscopolamine which is a peripherally acting antimuscarinic, anticholinergic agent.

Caffeic acid is an organic compound that is classified as hydroxycinnamic acid.

Calcitriol (Rocaltrol) increases blood calcium levels ( [Ca2+] ) by promoting absorption of dietary calcium from the gastrointestinal tract and increasing renal tubular reabsorption of calcium thus reducing the loss of calcium in the urine.

Cefaclor is a second-generation cephalosporin antibiotic used to treat certain infections caused by bacteria such as pneumonia and ear, lung, skin, throat, and urinary tract infections.

Cefprozil hydrate is a second-generation cephalosporin type antibiotic. It can be used to treat bronchitis, ear infections, skin infections, and other bacterial infections.

Ceftiofur is an antibiotic of the cephalosporin type (third generation)

Chenodeoxycholic acid is synthesized in the liver from cholesterol.

Chlormezanone (Trancopal), a non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. Chlormezanone binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.

Chlorothiazide is a diuretic and also used as an antihypertensive.

Cinchonidine is an alkaloid used in asymmetric synthesis in organic chemistry. It is a stereoisomer and pseudo-enantiomer of cinchonine.

Clindamycin is a lincosamide antibiotic. It is usually used to treat infections with anaerobic bacteria, but can also be used to treat some protozoal diseases, such as malaria.

Coenzyme Q10 is a component of the mitochondrial transporter chain that behaves as a powerful antioxidant. Displays neuroprotective activity.

In chemical structure, it is a corticosteroid closely related to corticosterone. It is used to treat a variety of ailments and can be administered intravenously, orally, intraarticularly (into a joint), or transcutaneously. Cortisone suppresses the immune system, thus reducing inflammation and attendant pain and swelling at the site of the injury.

Cyclovirobuxine D (Bebuxine) is an active compound extracted from Buxus microphylla that significantly increases cardiomyocytes viability injured by oxidation or hypoxia.

Cytarabine inhibits DNA replication by incorporating into DNA (IC50 = 0.04 μM in L1210 and CEM cell lines).

Cytisine is a nicotinic acetylcholine receptor agonist, and as a pharmaceutical preparation it is available for the treatment of nicotinism. It is a pyridine-like alkaloid that can be toxic in high doses. Pharmacologically it exhibits similar effects to nicotine due to structural similarity of the two molecules.

Desonide is the generic name of a low-potency topical corticosteroid .

Dexrazoxane hydrochloride is a cardioprotective agent. As a derivative of EDTA, dexrazoxane chelates iron, but the precise mechanism by which it protects the heart is not known. This agent is used to protect the heart against the cardiotoxic side effects of anthracyclines, such as doxorubicin.

D-glutamine is a D type stereoisomer of glutamine which is one of the 20 amino acids encoded by the standard genetic code.

Diclofensine (Ro 8-4650) acts as a triple monoamine reuptake inhibitor, primarily inhibiting the reuptake of dopamine and noradrenaline.

Dienestrol is a synthetic estrogen.

Dimesna is an uroprotective agent used to decrease urotoxicity.

Dioscin (Collettiside III) is extracted and isolated from Polygonatum Zanlanscianense Pamp with IC50 of 2.6, 0.8, 7.5, and 4.5 μM for the inhibition of the growth of the MDA-MB-435, H14, HL60, and HeLa cell lines, respectively.

Diosmin is a semisynthetic phlebotropic agent and a member of the flavonoid family.

Diphenhydramine is a first-generation antihistamine possessing anticholinergic, antitussive, antiemetic and sedative properties which is mainly used to treat allergies.

Divalproex sodium consists of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form. It is used in the United Kingdom, Canada, and United States for the treatment of the manic episodes of bipolar disorder.

DL-Carnitine hydrochloride is a quaternary ammonium compound biosynthesized from the amino acids lysine and methionine. In living cells, it is required for the transport of fatty acids from the cytosol into the mitochondria during the breakdown of lipids (fats) for the generation of metabolic energy.

D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.

Docosanol is an antiviral agent for reducing the duration of cold sores caused by the herpes simplex virus. It is thought to act by inhibiting the fusion of the human host cell with the viral envelope of the herpes virus, thus preventing its replication.

Dofetilide is a class III antiarrhythmic agent. Dofetilide works by selectively blocking the rapid component of the delayed rectifier outward potassium current (Ikr).

Doxercalciferol is a synthetic analog of ergocalciferol (vitamin D2). It suppresses parathyroid synthesis and secretion.

Econazole nitrate is an antifungal medication of the imidazole class.

Ergosterol is a sterol and a biological precursor (a provitamin) to vitamin D2. Ergosterol is a component of fungal cell membranes, serving the same function that cholesterol serves in animal cells. Because ergosterol is present in fungal cell membranes yet absent in animal cell membranes, it is a useful target for antifungal drugs. .

Flucytosine is an antifungal used in the treatment of severe candidal and cryptococcal infections. It converted to fluorouracil after entering fungi, which inhibits DNA and RNA synthesis

Formononetin (Formononetol) is a phytoestrogen from the root of Astragalus membranaceus and an O-methylated isoflavone. It is used as a blood enhancer and to improve blood microcirculation in complementary and alternative medicine. It promotes endothelial repair and wound healing in a process involving the over-expression of Egr-1 transcription factor through the regulation of the ERK1/2 and p38 MAPK pathways.

Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor.

Fumalic acid(Ferulic acid) is a hydroxycinnamic acid and a type of organic compound found in the Ferula assafoetida L. or Ligusticum chuanxiong. It has many pharmacology functions, such as anti-blood platelet collection , ease pain better the alive of prostate , relax the blood vessel convulsion.

Gadodiamide is a gadolinium-based MRI contrast agent, used in MR imaging procedures to assist in the visualization of blood vessels.

Gastrodin (Gastrodine) is a polyphenol. It is the glucoside of 4-hydroxybenzyl alcohol (gastrodigenin).

Gentamycin(Gentacycol) is an aminoglycoside antibiotic and was isolated from Micromonospora species

Gestodene is a progestogen hormonal contraceptive.

L-Glutamine is one of the 20 amino acids encoded by the standard genetic code.

Guaifenesin(Guaiphenesin) is thought to act as an expectorant.

Gynostemma Extract is a saponins extract derived from the Gynostemma pentaphyllum. The increase of SGOT, SGPT activities in CCl4 liver injury were significantly reduced by treatment with Gypenoside. It also elevated the A/G ratio.

Hesperidin is a flavanone glycoside found abundantly in citrus fruits.

Hydrochlorothiazide is a first line diuretic compound of the thiazide class.

Hydroxyurea (Cytodrox) is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.