Goblet-cell metaplasia in an elastase-exposed mouse model
Animal study · Female BALB/c mice, 8–10 weeks; leukocyte-elastase airway injury model; n=6 mice per group. [1]
Fudosteine reduced the PAS goblet-cell score versus elastase plus saline (P<0.05). This histological endpoint does not establish direct kinase inhibition.
| Endpoint | Reported result | Reference |
|---|---|---|
| Goblet-cell metaplasia, assessed by alcian blue/PAS histology | Ordinal PAS score (0–4) Lower with fudosteine versus LE group; P<0.05; mean ± SEM; n=6 per group. | [1] |
Conditions shared by the study groups
- Route
- Intraperitoneal
- Frequency
- Daily (Figure 1)
- Treatment course
- Days 8–12; day-13 histology
- Vehicle
- Saline
| Group / dose | Comparator | Observed result | Reference |
|---|---|---|---|
| Elastase + fudosteine Methods/Figure 1: 1 mg/200 μL in saline; abstract: 50 μg/g body weight. | Elastase + saline; saline-exposed baseline group also included. | PAS score decreased versus elastase + saline (P<0.05). | [1] |
- Elastase + fudosteine
- Model: Female BALB/c mice; n=6 per group.
- Reported limits: Dose descriptions retained as reported without assuming equivalence; individual animal weights not provided.
Methods and source locations
Compound reported in the paper: Fudosteine
Literature fudosteine; no Adooq lot validation or clinical efficacy inference.
pp. 152–155, Animals, LE-induced lung injury model, Lung histopathology, Statistical analysis; Figures 1–3 and captions
Goblet-cell metaplasia, assessed by alcian blue/PAS histology: Three fields per mouse lung; Figure 3 and caption. Exact bar heights were not digitized. — p. 153, Lung histopathology; pp. 154–155, Figures 2–3 and captions
Elastase + fudosteine · p. 151 abstract; p. 152 model methods; p. 153 Figure 1; pp. 154–155 Figures 2–3