Thiamet G

Catalog No.: A12895

O-GlcNAcase inhibitor

Thiamet G

Thiamet G Chemical Structure

CAS NO. 1009816-48-1

Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal-hexosaminidase.

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Package Price Qty
5 mg
$55.00
10 mg
$95.00
25 mg
$200.00
50 mg
$350.00
10mM * 1mL in DMSO
$89.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Zhu WZ, .et al. O-GlcNAc Transferase Promotes Compensated Cardiac Function and Protein Kinase A O-GlcNAcylation During Early and Established Pathological Hypertrophy From Pressure Overload, J Am Heart Assoc, 2019, Jun 4;8(11):e011260 PMID: 31131693

Biological Activity

Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37,000-fold selectivity over human lysosomal-hexosaminidase.
Targets
O-GlcNAcase
21 nM(Ki)
In vitro (25°C) DMSO 47 mg/mL (189.28 mM)
Water 47 mg/mL (189.28 mM)
Ethanol 11 mg/mL (44.29 mM)
In vivo Saline 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 40.27 mL 201.37 mL 402.74 mL
0.5 mM 8.05 mL 40.27 mL 80.55 mL
1 mM 4.03 mL 20.14 mL 40.27 mL
5 mM 0.81 mL 4.03 mL 8.05 mL

*The above data is based on the productmolecular weight 248.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12895
Actions Inhibitor
CAS No. 1009816-48-1
Formula C9H16N2O4S
M. Wt 248.3
Solubility DMSO
Purity >98%
SMILES CCNC1=NC2C(C(C(OC2S1)CO)O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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