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$0.00 - Yue Sheng, .et al. Role of c-Myc haploinsufficiency in the maintenance of HSCs, Blood, 2020, Aug 21 PMID: 32822452
- Janne J. M. van Schie, .et al. Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion, Nat Commun, 2020, 11: 4287 PMID: 32855419
- Hald øH, .et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma, Oncogene, 2018, Dec 12 PMID: 30542116
- Louise E. Kerry, .et al. Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis, PLoS Negl Trop Dis, 2017, Mar; 11(3): e0005432 PMID: 28263991
Biological Activity
Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.
| In vitro (25°C) | DMSO | Warmed: 18 mg/mL (35.57 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 2% DMSO+30% PEG 300+dd H2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.54 mL | 82.69 mL | 165.38 mL |
| 0.5 mM | 3.31 mL | 16.54 mL | 33.08 mL |
| 1 mM | 1.65 mL | 8.27 mL | 16.54 mL |
| 5 mM | 0.33 mL | 1.65 mL | 3.31 mL |
*The above data is based on the productmolecular weight 604.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12380 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 865311-47-3 |
| Formula | C35H33FN6O3 |
| M. Wt | 604.67 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | CX 3543; Quarfloxacin; CX3543; CX-3543 |
| SMILES | CN1CCC[[email protected]]1CCNC(=O)C2=CN3C4=CC5=CC=CC=C5C=C4OC6=C3C(=CC(=C6N7CCC(C7)C8=NC=CN=C8)F)C2=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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