Quarfloxin (CX-3543)

Catalog No.: A12380

rRNA biogenesis inhibitor

Quarfloxin (CX-3543)

Quarfloxin (CX-3543) Chemical Structure

CAS NO. 865311-47-3

Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.

Availability: In stock

Package Price Qty
5 mg
$250.00
10 mg
$450.00
25 mg
$900.00
50 mg
$1,600.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Hald øH, .et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma, Oncogene, 2018, Dec 12 PMID: 30542116
  • Louise E. Kerry, .et al. Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis, PLoS Negl Trop Dis, 2017, Mar; 11(3): e0005432 PMID: 28263991

Biological Activity

Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.54 mL 82.69 mL 165.38 mL
0.5 mM 3.31 mL 16.54 mL 33.08 mL
1 mM 1.65 mL 8.27 mL 16.54 mL
5 mM 0.33 mL 1.65 mL 3.31 mL

*The above data is based on the productmolecular weight 604.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12380
Actions Inhibitor
M. Wt 604.67
Formula C35H33FN6O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 865311-47-3
Synonyms CX 3543; Quarfloxacin; CX3543; CX-3543
SMILES CN1CCC[[email protected]]1CCNC(=O)C2=CN3C4=CC5=CC=CC=C5C=C4OC6=C3C(=CC(=C6N7CCC(C7)C8=NC=CN=C8)F)C2=O

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