Quarfloxin (CX-3543)

Catalog No.: A12380

rRNA biogenesis inhibitor

Quarfloxin (CX-3543)

Quarfloxin (CX-3543) Chemical Structure

CAS NO. 865311-47-3

Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.

Availability: In stock

Package Price Qty
5 mg
$250.00
10 mg
$450.00
25 mg
$900.00
50 mg
$1,600.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Yue Sheng, .et al. Role of c-Myc haploinsufficiency in the maintenance of HSCs, Blood, 2020, Aug 21 PMID: 32822452
  • Janne J. M. van Schie, .et al. Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion, Nat Commun, 2020, 11: 4287 PMID: 32855419
  • Hald øH, .et al. Inhibitors of ribosome biogenesis repress the growth of MYCN-amplified neuroblastoma, Oncogene, 2018, Dec 12 PMID: 30542116
  • Louise E. Kerry, .et al. Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis, PLoS Negl Trop Dis, 2017, Mar; 11(3): e0005432 PMID: 28263991

Biological Activity

Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.
In vitro (25°C) DMSO Warmed: 18 mg/mL (35.57 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+dd H2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.54 mL 82.69 mL 165.38 mL
0.5 mM 3.31 mL 16.54 mL 33.08 mL
1 mM 1.65 mL 8.27 mL 16.54 mL
5 mM 0.33 mL 1.65 mL 3.31 mL

*The above data is based on the productmolecular weight 604.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12380
Actions Inhibitor
CAS No. 865311-47-3
Formula C35H33FN6O3
M. Wt 604.67
Purity >98%
Synonyms CX 3543; Quarfloxacin; CX3543; CX-3543
SMILES CN1CCC[[email protected]]1CCNC(=O)C2=CN3C4=CC5=CC=CC=C5C=C4OC6=C3C(=CC(=C6N7CCC(C7)C8=NC=CN=C8)F)C2=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy Quarfloxin (CX-3543) | Quarfloxin (CX-3543) Supplier | purchase | cost | manufacturer | order | distributor | buy 865311-47-3| 865311-47-3 Supplier | purchase 865311-47-3 | 865311-47-3 cost | 865311-47-3 manufacturer | order 865311-47-3 | 865311-47-3 distributor
Rewards