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Biological Activity
Calcineurin inhibitory peptide is a selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 uM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 3.41 mL | 17.06 mL | 34.12 mL |
| 0.5 mM | 0.68 mL | 3.41 mL | 6.82 mL |
| 1 mM | 0.34 mL | 1.71 mL | 3.41 mL |
| 5 mM | 0.07 mL | 0.34 mL | 0.68 mL |
*The above data is based on the productmolecular weight 2930.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15376 |
|---|---|
| CAS No. | 148067-21-4 |
| Formula | C124H205N39O39S |
| M. Wt | 2930.7 |
| Purity | >98% |
| SMILES | CC[[email protected]](C)[[email protected]@H](C(=O)N[[email protected]@H]([[email protected]@H](C)O)C(=O)N[[email protected]@H](CO)C(=O)N[[email protected]@H](CC1=CC=CC=C1)C(=O)N[[email protected]@H](CCC(=O)O)C(=O)N[[email protected]@H](CCC(=O)O)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](CCCCN)C(=O)NCC(=O)N[[email protected]@H](CC(C)C)C(=O)N[[email protected]@H](CC(=O)O)C(=O)N[[email protected]@H](CCCNC(=N)N)C(=O)N[[email protected]@H]([[email protected]@H](C)CC)C(=O)N[[email protected]@H](CC(=O)N)C(=O)N[[email protected]@H](CCC(=O)O)C(=O)N[[email protected]@H](CCCNC(=N)N)C(=O)N[[email protected]@H](CCSC)C(=O)N2CCC[[email protected]]2C(=O)N3CCC[[email protected]]3C(=O)N[[email protected]@H](CCCNC(=N)N)C(=O)N[[email protected]@H](CCCNC(=N)N)C(=O)N[[email protected]@H](CC(=O)O)C(=O)N[[email protected]@H](C)C(=O)N[[email protected]@H](CCSC)C(=O)N4CCC[[email protected]]4C(=O)O)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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